Overview
- Authors:
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Ulrich Hübscher
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University of Zurich, Zurich, Switzerland
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Silvio Spadari
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Institute of Biochemical and Evolutionary Genetics, CNR, Pavia, Italy
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About this book
This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.
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Table of contents (58 chapters)
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In Vitro Prokaryotic DNA Replication Systems
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- C. Victor Jongeneel, Timothy Formosa, Maureen Munn, Bruce M. Alberts
Pages 17-33
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- Margarita Salas, Luis Blanco, Ignacio Prieto, Juan A. García, Rafael P. Mellado, José M. Lázaro et al.
Pages 35-44
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- K. Geider, T. F. Meyer, I. Bäumel, A. Reimann
Pages 45-54
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- Ramon Diaz, Walter L. Staudenbauer
Pages 55-61
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- N. Patrick Higgins, Purita Manlapaz-Ramos, Baldomero M. Olivera
Pages 63-67
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- Anne Resibois, Martin Pato, Patrick Higgins, Ariane Toussaint
Pages 69-76
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- Jonathan H. LeBowitz, Roger McMacken
Pages 77-89
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In Vitro Eukaryotic DNA Replication Systems, Chromosomal and Viral Replication Studies
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- Peter C. van der Vliet, Bram G. M. van Bergen, Wim van Driel, Dick van Dam, Marijke M. Kwant
Pages 93-105
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- N. Overbeeke, J. H. de Waard, A. J. Kool
Pages 107-112
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- J. M. Bonneville, M. Volovitch, N. Modjtahedi, D. Demery, P. Yot
Pages 113-119
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- P. Pfeiffer, P. Laquel, T. Hohn
Pages 121-125
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- Wolfgang Pülm, Rolf Knippers
Pages 127-141
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- J.-M. Vos, B. Avalosse, Z. Z. Su, J. Rommelaere
Pages 143-150
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- Nicholas Muzyczka, Richard J. Samulski, Paul Hermonat, Arun Srivastava, Kenneth I. Berns
Pages 151-161
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- Monique Marilley, Mario Buongiorno-Nardelli
Pages 163-168
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- Silvio Spadari, Francesco Sala, Guido Pedrali-Noy
Pages 169-181
Authors and Affiliations
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University of Zurich, Zurich, Switzerland
Ulrich Hübscher
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Institute of Biochemical and Evolutionary Genetics, CNR, Pavia, Italy
Silvio Spadari