Relationship between the Organization of DNA Loop Domains and of Replicons in the Eukaryotic Genome
The DNA in the eukaryotic nucleus has been found to be arranged in a series of supercoiled loops. This supercoiled loop-organization results from DNA attachment to a structure which is mainly proteic, the so-called nuclear matrix (1–9). This DNA organization remains stable throughout the cellular cycle as far as the size of DNA loops and the anchorage sites are concerned (5, 10, 11). It is worthwhile noting that this type of organization has been found in all cells whatever their state of differentiation (early embryonic stage up to fully differentiated cells (21)).
KeywordsXenopus Laevis Nuclear Matrix Early Embryonic Stage Anchorage Site Eukaryotic Nucleus
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