Relationship between the Organization of DNA Loop Domains and of Replicons in the Eukaryotic Genome

  • Monique Marilley
  • Mario Buongiorno-Nardelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


The DNA in the eukaryotic nucleus has been found to be arranged in a series of supercoiled loops. This supercoiled loop-organization results from DNA attachment to a structure which is mainly proteic, the so-called nuclear matrix (1–9). This DNA organization remains stable throughout the cellular cycle as far as the size of DNA loops and the anchorage sites are concerned (5, 10, 11). It is worthwhile noting that this type of organization has been found in all cells whatever their state of differentiation (early embryonic stage up to fully differentiated cells (21)).


Xenopus Laevis Nuclear Matrix Early Embryonic Stage Anchorage Site Eukaryotic Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Monique Marilley
    • 1
  • Mario Buongiorno-Nardelli
    • 2
  1. 1.LA 179 - Faculté des Sciences de LuminyMarseille cedex 9France
  2. 2.Department of Genetic, Facoltà di scienze M.F.N.Università di RomaRomeItaly

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