Replication of Bacteriophage Mu and its Mini-Mu Derivatives

  • Anne Resibois
  • Martin Pato
  • Patrick Higgins
  • Ariane Toussaint
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)


The temperate phage Mu behaves as a transposing replicon. During its whole replication phase, which starts 6–8 min after the onset of the lytic cycle, it remains attached to host DNA; the original Mu prophage remains in the host chromosome (1) and the bacterial nucleoid remains intact (2). Only Mu sequences are replicated in vivo (3) and in vitro (4, 5), implying that replication is initiated in or at the ends of the phage genome and terminates at the ends.


Inverted Repeat Phage Genome Lytic Cycle Replication Intermediate Separate Strand 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Anne Resibois
    • 1
  • Martin Pato
    • 2
  • Patrick Higgins
    • 3
  • Ariane Toussaint
    • 4
  1. 1.Laboratoire d’HistologieUniversité Libre de BruxellesBruxellesBelgium
  2. 2.Department of Molecular and Cellular BiologyNational Jewish Hospital and Research CenterDenverUSA
  3. 3.Department of BiochemistryUniversity of AlabamaBirminghamUSA
  4. 4.Laboratoire de GenetiqueUniversité Libre de BruxellesRhode St. GeneseBelgium

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