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Enzymological Studies of the T4 Replication Proteins

  • C. Victor Jongeneel
  • Timothy Formosa
  • Maureen Munn
  • Bruce M. Alberts
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 179)

Abstract

Ever since the pioneering efforts of Delbruck and the early phage workers, bacteriophage T4 has been a favorite model for unraveling the fundamental processes of molecular genetics. The replication of double-stranded DNA is no exception, even though it was not until the last ten years or so that substantial progress was made in purifying the gene products involved in this process. Extensive genetic analysis of bacteriophage T4 has identified eleven genes whose products appear to be directly involved in the formation and subsequent moving of DNA replication forks: genes 32, 39, 41, 43, 44, 45, 52, 60, 61, 62, and dda (1–5). The proteins specified by these genes have all been isolated and purified to near homogeneity (6–10, Jongeneel, Formosa and Alberts, submitted).

Keywords

Replication Fork recA Protein Promoter Site Recombination Intermediate Okazaki Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • C. Victor Jongeneel
    • 1
  • Timothy Formosa
    • 2
  • Maureen Munn
    • 2
  • Bruce M. Alberts
    • 2
  1. 1.Swiss Institute for Experimental Cancer ResearchEpalingesSwitzerland
  2. 2.Department of Biochemistry and BiophysicsUniversity of California, San FranciscoSan FranciscoUSA

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