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DNA Polymerase ε

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The Eukaryotic Replisome: a Guide to Protein Structure and Function

Part of the book series: Subcellular Biochemistry ((SCBI,volume 62))

Abstract

DNA polymerase ε (Pol ε) is one of three replicative DNA polymerases in eukaryotic cells. Pol ε is a multi-subunit DNA polymerase with many functions. For example, recent studies in yeast have suggested that Pol ε is essential during the initiation of DNA replication and also participates during leading strand synthesis. In this chapter, we will discuss the structure of Pol ε, the individual subunits and their function.

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Acknowledgements

This work is supported by Kempestiftelserna (M.H. and E.J), the Swedish Research Council, the Swedish Cancer Society, and Smärtafonden (E.J).

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  1. Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, SE-90187, Sweden

    Matthew Hogg & Erik Johansson

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Correspondence to Erik Johansson .

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    Stuart MacNeill

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Hogg, M., Johansson, E. (2012). DNA Polymerase ε. In: MacNeill, S. (eds) The Eukaryotic Replisome: a Guide to Protein Structure and Function. Subcellular Biochemistry, vol 62. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4572-8_13

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