Ins and outs of AlphaFold2 transmembrane protein structure predictions Tamás HegedűsMarkus GeislerBianka Farkas Original Article Open access 15 January 2022 Article: 73
Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells Zeyuan WangLehao WuHua Xiao Original Article 15 January 2022 Article: 72
The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair Yixuan Amy PeiSong ChenMing Pei Review 14 January 2022 Article: 71
Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression Tingting ZouYang WangZhenghong Lin Original Article Open access 12 January 2022 Article: 70
UCP1 and AOX1a contribute to regulation of carbon and nitrogen metabolism and yield in Arabidopsis under low nitrogen stress Xinyan QiaoMengjiao RuanYurong Bi Original Article 02 January 2022 Article: 69
Development of a novel and synthetic HematoMiR technology that broadly modulates quiescence of stem cells and enhances HSC expansion Merve UsluFatih Kocabaş Original Article 31 December 2021 Article: 68
Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides Loretta FerreraFloriana CappielloMaria Luisa Mangoni Original Article Open access 31 December 2021 Article: 67
Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis Peiyan ZhengShixue SunBaoqing Sun Original Article 11 January 2022 Article: 66
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses André SchreiberDorothee ViemannStephan Ludwig Original Article Open access 10 January 2022 Article: 65
A novel effect of PDLIM5 in α7 nicotinic acetylcholine receptor upregulation and surface expression Zi-Lin LiChen-Yu GouYuan Chen Original Article 10 January 2022 Article: 64
Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy Chang DaiPrabuddha WadugeWei Li Original Article 10 January 2022 Article: 63
Host glyceraldehyde-3-phosphate dehydrogenase-mediated iron acquisition is hijacked by intraphagosomal Mycobacterium tuberculosis Anil PatidarHimanshu MalhotraManoj Raje Original Article 09 January 2022 Article: 62
Plasmolipin regulates basolateral-to-apical transcytosis of ICAM-1 and leukocyte adhesion in polarized hepatic epithelial cells Cristina Cacho-NavasNatalia Reglero-RealJaime Millán Original Article Open access 09 January 2022 Article: 61
The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis Libo LiuJiaxiang LiRuoxi Wang Review 09 January 2022 Article: 60
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling Wenwen ZhangShuofei YangXiaoxiang Guan Original Article 07 January 2022 Article: 59
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations María Guadalupe Herrera-HernándezNeda RazzaghiPere Garriga Original Article Open access 07 January 2022 Article: 58
Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation Barbara SchreierVirginie DubourgMichael Gekle Original Article Open access 18 December 2021 Article: 57
Evolving features of human cortical development and the emerging roles of non-coding RNAs in neural progenitor cell diversity and function Kanella ProdromidouRebecca Matsas Review 18 December 2021 Article: 56
Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis Martina StaziSandra LehmannOliver Wirths Original Article Open access 16 December 2021 Article: 55
GSTpi reduces DNA damage and cell death by regulating the ubiquitination and nuclear translocation of NBS1 Jinyi ZhouLili GuZhimin Yin Original Article 22 December 2021 Article: 54
Roles of SIRT6 in kidney disease: a novel therapeutic target Xueyan YangJun FengGuohua Ding Review 24 December 2021 Article: 53
Identification of inflammatory markers in eosinophilic cells of the immune system: fluorescence, Raman and CARS imaging can recognize markers but differently Aleksandra Borek-DoroszMarek GrosickiMalgorzata Baranska Original Article Open access 22 December 2021 Article: 52
Mechanisms supporting aminoadenine-based viral DNA genomes P. A. Kaminski Review 15 December 2021 Article: 51
FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development Teresa ChioccarelliGeppino FalcoFrancesco Manfrevola Original Article Open access 22 December 2021 Article: 50
TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes Hyunseung SunEunmi KimJung Weon Lee Original Article Open access 18 December 2021 Article: 49
Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides Andreas ZietzerAlina Lisann JahnelFelix Jansen Original Article Open access 24 December 2021 Article: 48
Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells Julia Sirés-CamposAna LambertosJosé Carlos García-Borrón Original Article Open access 18 December 2021 Article: 47
Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for autism spectrum disorders Ann Katrin SauerSigita MalijauskaiteAndreas M. Grabrucker Original Article 22 December 2021 Article: 46
PA28γ–20S proteasome is a proteolytic complex committed to degrade unfolded proteins Jean-Yves Alejandro FrayssinhesFulvia CerrutiPaolo Cascio Original Article 16 December 2021 Article: 45
Silencing the triacylglycerol lipase (TGL) gene decreases the number of apyrene sperm and inhibits oviposition in Sitotroga cerealella Wen-han YanMeng-Ya WuFeng-Lian Yang Original Article 31 December 2021 Article: 44
MIAT, a potent CVD-promoting lncRNA Chao YangYong ZhangBaofeng Yang Review 18 December 2021 Article: 43
LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia Yu LiQiuyang ZhangHuaiyong Chen Original Article Open access 18 December 2021 Article: 42
Acute hypoxia elevates arginase 2 and induces polyamine stress response in zebrafish via evolutionarily conserved mechanism Bodhisattwa BanerjeeIryna KhrystoforovaDavid Karasik Original Article 16 December 2021 Article: 41
Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood Christian KretzerBlerina ShkodraOliver Werz Original Article Open access 31 December 2021 Article: 40
MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury Zhi RuanQing LuYingfei Wang Original Article 18 December 2021 Article: 39
Modified horseshoe crab peptides target and kill bacteria inside host cells Anna S. AmissJessica B. von PeinNicole Lawrence Original Article 31 December 2021 Article: 38
eNOS controls angiogenic sprouting and retinal neovascularization through the regulation of endothelial cell polarity Tracy L. SmithMalika OubahaJean-Philippe Gratton Original Article Open access 31 December 2021 Article: 37
Oxidative stress and Rho GTPases in the biogenesis of tunnelling nanotubes: implications in disease and therapy Abinaya RaghavanPooja RaoSangeeta Nath Review Open access 18 December 2021 Article: 36
Shrew's venom quickly causes circulation disorder, analgesia and hypokinesia Zhiyi LiaoXiaopeng TangRen Lai Original Article 06 January 2022 Article: 35
Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy Ana MitrovićJanja ZavršnikJanko Kos Original Article Open access 06 January 2022 Article: 34
Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells Jose Sanchez-ColladoJose J. LopezJuan A. Rosado Original Article Open access 06 January 2022 Article: 33
Hypothalamic inflammation in metabolic disorders and aging Anup BhusalMd Habibur RahmanKyoungho Suk Review 15 December 2021 Article: 32
Hippocampal BMP signaling as a common pathway for antidepressant action Elif Tunc-OzcanSarah M. BrookerJohn A. Kessler Original Article 22 December 2021 Article: 31
Reply to Guo’s commentary on: “Immune cells lacking Y chromosome show dysregulation of autosomal gene expression” Lars A. Forsberg Letter to the Editor Open access 15 December 2021 Article: 30
Eusociality is linked to caste-specific differences in metabolism, immune system, and somatic maintenance-related processes in an ant species Martin QuqueClaire VilletteDimitri Heintz Original Article 31 December 2021 Article: 29
Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways Ivana BarravecchiaChiara De CesariDebora Angeloni Original Article 22 December 2021 Article: 28
Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors Yuping TanXia ZhouQingxiang Sun Original Article 31 December 2021 Article: 27
TRP channel expression correlates with the epithelial–mesenchymal transition and high-risk endometrial carcinoma Charlotte Van den EyndeKatrien De ClercqJoris Vriens Original Article Open access 22 December 2021 Article: 26
Circulating extracellular vesicles and rheumatoid arthritis: a proteomic analysis Mohammed AlghamdiSultan Abdulmughni AlamryElrashdy M. Redwan Review 31 December 2021 Article: 25
Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling Vinay Kumar SharmaXuyu YangY. Peng Loh Original Article Open access 29 December 2021 Article: 24