1. Modifications of the human tRNA anticodon loop and their associations with genetic diseases

   • Jing-Bo Zhou
   • En-Duo Wang
   • Xiao-Long Zhou

   Review 04 October 2021 Pages: 7087 - 7105

   

2. Recapitulating pancreatic cell–cell interactions through bioengineering approaches: the momentous role of non-epithelial cells for diabetes cell therapy

   • Zahra Ghezelayagh
   • Mahsa Zabihi
   • Yaser Tahamtani

   Review 06 October 2021 Pages: 7107 - 7132

   

3. The molecular identity of the TLQP-21 peptide receptor

   • Bhavani S. Sahu
   • Megin E. Nguyen
   • Alessandro Bartolomucci

   Review Open access 09 October 2021 Pages: 7133 - 7144

   

4. The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events

   • Shekoufeh Almasi
   • Bernard J. Jasmin

   Review Open access 11 October 2021 Pages: 7145 - 7160

   

5. Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases

   • Zhiguo Ling
   • Chuan Yang
   • Yueqi Chen

   Review 11 October 2021 Pages: 7161 - 7183

   

6. Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

   • Ofek Oren
   • Ran Taube
   • Niv Papo

   Review 13 October 2021 Pages: 7185 - 7198

   

7. RIPK3 signaling and its role in the pathogenesis of cancers

   • Shanhui Liu
   • Kanak Joshi
   • Jiwang Zhang

   Review 15 October 2021 Pages: 7199 - 7217

   

8. Developmentally regulated GTPases: structure, function and roles in disease

   • Christian A. E. Westrip
   • Qinqin Zhuang
   • Mathew L. Coleman

   Review Open access 19 October 2021 Pages: 7219 - 7235

   

9. The influenza virus RNA polymerase as an innate immune agonist and antagonist

   • Elizaveta Elshina
   • Aartjan J. W. te Velthuis

   Review Open access 22 October 2021 Pages: 7237 - 7256

   

10. The Hsp70–Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration

    • Kaushik Bhattacharya
    • Didier Picard

    Review Open access 22 October 2021 Pages: 7257 - 7273

    

11. The impact of obesity on adipocyte-derived extracellular vesicles

    • Hiu Yee Kwan
    • Minting Chen
    • Baisen Chen

    Review 22 October 2021 Pages: 7275 - 7288

    

12. Neural circuit mechanisms that govern inter-male attack in mice

    • Xi Zha
    • Xiao-Hong Xu

    Review 23 October 2021 Pages: 7289 - 7307

    

13. Alpha and beta myosin isoforms and human atrial and ventricular contraction

    • Jonathan Walklate
    • Cecilia Ferrantini
    • Michael A. Geeves

    Review Open access 26 October 2021 Pages: 7309 - 7337

    

14. Key features of the POU transcription factor Oct4 from an evolutionary perspective

    • Evgeny I. Bakhmet
    • Alexey N. Tomilin

    Review 26 October 2021 Pages: 7339 - 7353

    

15. MicroRNA-34a: the bad guy in age-related vascular diseases

    • Angela Raucci
    • Federica Macrì
    • Estella Zuccolo

    Review Open access 26 October 2021 Pages: 7355 - 7378

    

16. Axonal mRNA localization and translation: local events with broad roles

    • Lichao Li
    • Jun Yu
    • Sheng-Jian Ji

    Review 26 October 2021 Pages: 7379 - 7395

    

17. Genomics of Alzheimer’s disease implicates the innate and adaptive immune systems

    • Yihan Li
    • Simon M. Laws
    • Ben J. Gu

    Review 27 October 2021 Pages: 7397 - 7426

    

18. The crosstalk between viral RNA- and DNA-sensing mechanisms

    • Chunmei Cai
    • Yan-Dong Tang
    • Chunfu Zheng

    Review 29 October 2021 Pages: 7427 - 7434

    

19. The lysosome as an imperative regulator of autophagy and cell death

    • Kewal Kumar Mahapatra
    • Soumya Ranjan Mishra
    • Sujit Kumar Bhutia

    Review 30 October 2021 Pages: 7435 - 7449

    

20. Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis

    • I. F. Duarte
    • J. Caio
    • M. F. B. Silva

    Review 31 October 2021 Pages: 7451 - 7468

    

21. Hypothalamic endocannabinoids in obesity: an old story with new challenges

    • Cristina Miralpeix
    • Ana Cristina Reguera
    • Rosalía Rodríguez-Rodríguez

    Review Open access 31 October 2021 Pages: 7469 - 7490

    

22. Mitigating the pro-oxidant state and melanogenesis of Retinitis pigmentosa: by counteracting mitochondrial dysfunction

    • Giovanni Pagano
    • Federico V. Pallardó
    • Marco Trifuoggi

    Review 31 October 2021 Pages: 7491 - 7503

    

23. OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1

    • Clara Boces-Pascual
    • Aida Mata-Ventosa
    • Sandra Pérez-Torras

    Original Article Open access 13 October 2021 Pages: 7505 - 7518

    

24. Structure–function relationships explain CTCF zinc finger mutation phenotypes in cancer

    • Charles G. Bailey
    • Shailendra Gupta
    • John E. J. Rasko

    Original Article Open access 16 October 2021 Pages: 7519 - 7536

    

25. Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker

    • Camila Espejo
    • Richard Wilson
    • A. Bruce Lyons

    Original Article 16 October 2021 Pages: 7537 - 7555

    

26. Kappa but not delta or mu opioid receptors form homodimers at low membrane densities

    • Kristina Cechova
    • Chenyang Lan
    • Maximilian H. Ulbrich

    Original Article Open access 17 October 2021 Pages: 7557 - 7568

    

27. The Na⁺-activated K⁺ channel Slack contributes to synaptic development and plasticity

    • Lucas Matt
    • Thomas Pham
    • Robert Lukowski

    Original Article Open access 18 October 2021 Pages: 7569 - 7587

    

28. Extracellular vesicle release and uptake by the liver under normo- and hyperlipidemia

    • Krisztina Németh
    • Zoltán Varga
    • Viola Tamási

    Original Article Open access 19 October 2021 Pages: 7589 - 7604

    

29. Functional molecular switches of mammalian G protein-coupled bitter-taste receptors

    • Jérémie Topin
    • Cédric Bouysset
    • Jérôme Golebiowski

    Original Article 23 October 2021 Pages: 7605 - 7615

    

30. Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN

    • Jialin Yao
    • Yingfeng Tu
    • Qingxiang Sun

    Original Article 23 October 2021 Pages: 7617 - 7633

    

31. Sam68 contributes to intestinal inflammation in experimental and human colitis

    • Wendy A. Goodman
    • Shrikanth C. Basavarajappa
    • Parameswaran Ramakrishnan

    Original Article 24 October 2021 Pages: 7635 - 7648

    

32. O₂ permeability of lipid bilayers is low, but increases with membrane cholesterol

    • Samer Al-Samir
    • Fabian Itel
    • Volker Endeward

    Original Article Open access 25 October 2021 Pages: 7649 - 7662

    

33. MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance

    • Dakota Becker-Greene
    • Hao Li
    • Basak Icli

    Original Article 26 October 2021 Pages: 7663 - 7679

    

34. Recombinant thrombomodulin domain 1 rescues pathological angiogenesis by inhibition of HIF-1α-VEGF pathway

    • Yi-Hsun Huang
    • Cheng-Hsiang Kuo
    • Hua-Lin Wu

    Original Article 27 October 2021 Pages: 7681 - 7692

    

35. Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types

    • Sadiq Umar
    • Karol Palasiewicz
    • Shiva Shahrara

    Original Article 27 October 2021 Pages: 7693 - 7707

    

36. GRP78 facilitates M2 macrophage polarization and tumour progression

    • Heng Zhang
    • Shao-Qiang Wang
    • Ri Chen

    Original Article 28 October 2021 Pages: 7709 - 7732

    

37. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

    • Dolores Piniella
    • Elena Martínez-Blanco
    • Francisco Zafra

    Original Article Open access 28 October 2021 Pages: 7733 - 7756

    

38. Apoptosis resistance of senescent cells is an intrinsic barrier for senolysis induced by cardiac glycosides

    • Pavel I. Deryabin
    • Alla N. Shatrova
    • Aleksandra V. Borodkina

    Original Article Open access 29 October 2021 Pages: 7757 - 7776

    

39. Snake venom phospholipase A₂s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2

    • Andrei E. Siniavin
    • Maria A. Streltsova
    • Yuri N. Utkin

    Original Article 29 October 2021 Pages: 7777 - 7794

    

40. Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment

    • Francesca Cialdai
    • Davide Bolognini
    • Matteo Lulli

    Original Article 29 October 2021 Pages: 7795 - 7812

    

41. Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR

    • Nesrine Baatallah
    • Ahmad Elbahnsi
    • Alexandre Hinzpeter

    Original Article 29 October 2021 Pages: 7813 - 7829

    

42. α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt–β-catenin pathway

    • Zewu Zhu
    • Shuhao Ruan
    • Hequn Chen

    Original Article 01 November 2021 Pages: 7831 - 7849

    

43. Vascular adhesion protein-1 defines a unique subpopulation of human hematopoietic stem cells and regulates their proliferation

    • Imtiaz Iftakhar-e-Khuda
    • Alberto Pessia
    • Sirpa Jalkanen

    Original Article Open access 01 November 2021 Pages: 7851 - 7872

    

44. Role of Akt isoforms in neuronal insulin signaling and resistance

    • Medha Sharma
    • Chinmoy Sankar Dey

    Original Article 01 November 2021 Pages: 7873 - 7898

    

45. Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

    • Ehab Al-Moubarak
    • Holly A. Shiels
    • Jules C. Hancox

    Original Article Open access 02 November 2021 Pages: 7899 - 7914

    

46. Correction to: TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development

    • Mei Yi
    • Yixin Tan
    • Bo Xiang

    Correction 02 November 2021 Pages: 7915 - 7915