Benchmark Glycan Profile of Therapeutic Monoclonal Antibodies Produced by Mammalian Cell Expression Systems Shen LuoBaolin Zhang Original Research Article Open access 01 November 2023 Pages: 29 - 37
A survey of FDA Approved Monoclonal Antibodies and Fc-fusion Proteins for Manufacturing Changes and Comparability Assessment Zhe LiXiulian DuYow-Ming C. Wang Original Research Article 01 November 2023 Pages: 13 - 27
Effect of Food Viscosity on Drug Dissolution Rika HiroseKiyohiko Sugano Original Research Article 26 October 2023 Pages: 105 - 112
Validation of Anti-Adeno Associated Virus Serotype rh10 (AAVrh.10) Total and Neutralizing Antibody Immunogenicity Assays Elizabeth Butala-FloresThien NguyenAmanda Hays Original Research Article Open access 25 October 2023 Pages: 2383 - 2397
Examination of the Rate and Extent of Drug Released from Commercial Topical Delivery Systems During Wear: An Example with Lidocaine Topical Systems Qing CaiArmita AzarpanahNicole K. Brogden Original Research Article 17 October 2023 Pages: 39 - 50
Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals Yong ZhangSejal SharmaThomas J. Abbruscato Original Research Article 13 October 2023 Pages: 2747 - 2758
Hydration Mechanism and Its Effect on the Solubility of Aripiprazole Zhixin ZhengXin HuangHongxun Hao Original Research Article 13 October 2023 Pages: 113 - 127
Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin Pallabi MitraRumanah KasliwalaMitchell E. Taub Original Research Article 11 October 2023 Pages: 3025 - 3042
Cortisol as Biomarker for CYP17-Inhibition is Associated with Therapy Outcome of Abiraterone Acetate Maaike A. C. BruinMa Ida Mohmaed AliAlwin D. R. Huitema Original Research Article 11 October 2023 Pages: 3001 - 3010
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations Alicja PuszkielGuilhem BousquetXavier Declèves Original Research Article 11 October 2023 Pages: 2687 - 2697
Mitigation of Tribocharging in Pharmaceutical Powders using Surface Modified V-Blenders Tanu MehtaRaj MukherjeeBodhisattwa Chaudhuri Original Research Article 11 October 2023 Pages: 2371 - 2381
Industry Perspective – What does Industry Need to Accelerate Drug Product and Process Development? Bikash ChatterjeeRichard SteinerGoldi Kaul Perspective Open access 11 October 2023 Pages: 7 - 11
Assessing Dose-Exposure–Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach Shadrack J. MaduKe WangMingzhong Li Original Research Article Open access 10 October 2023 Pages: 2983 - 3000
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2 Floriane LignetManja Friese-HamimFelix Rohdich Original Research Article Open access 05 October 2023 Pages: 3011 - 3023
Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies Victor A. BeaumontLucy LiuHai-Young Kim Original Research Article Open access 05 October 2023 Pages: 2457 - 2467
Development and Validation of Discriminatory In-vitro Release Method for Intramammary Drug Product Nada A. HelalMarilyn N. MartinezMohammad T. H. Nutan Original Research Article 03 October 2023 Pages: 129 - 139
Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human Kai WangGordon L. AmidonDavid E. Smith Review Article 03 October 2023 Pages: 2607 - 2626
Practical Advice on Scientific Design of Freeze-Drying Process: 2023 Update Serguei TchessalovVito MaglioEvgenyi Shalaev Original Research Article Open access 02 October 2023 Pages: 2433 - 2455
In vivo Pharmacokinetic/Pharmacodynamic Analysis of the Efficacy of the Cefepime/Nacubactam Combination Against β-Lactamase-Producing Enterobacterales based on the Instantaneous MIC Concept Yuki IgarashiWataru TakemuraKazuaki Matsumoto Original Research Article 02 October 2023 Pages: 2423 - 2431
Modeling Gasotransmitter Availability to Brain Capillary Endothelial Cells with Ultrasound-sensitive Microbubbles Rubens JourdainVenkat Keshav ChivukulaChris A. Bashur Original Research Article 02 October 2023 Pages: 2399 - 2411
Small is Powerful: Demonstration of the Impact of Nanoformed Piroxicam in a Controlled Clinical Study Satu LakioDavid J. SmithEdward Hӕggström Original Research Article 01 November 2023 Pages: 2317 - 2327
Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets Daniel PuckhaberArno KwadeJan Henrik Finke Original Research Article Open access 26 September 2023 Pages: 2479 - 2492
An Update on Potential Molecular Biomarkers of Dietary Phytochemicals Targeting Lung Cancer Interception and Prevention Rebecca Mary PeterPochung Jordan ChouAh-Ng Tony Kong Review Article 19 September 2023 Pages: 2699 - 2714
Investigating the Impact of Co-processed Excipients on the Formulation of Bromhexine Hydrochloride Orally Disintegrating Tablets (ODTs) Krzysztof Woyna-OrlewiczWitold BrniakAleksander Mendyk Original Research Article Open access 19 September 2023 Pages: 2947 - 2962
Population Pharmacokinetics and Pharmacogenetics Analyses of Dasatinib in Chinese Patients with Chronic Myeloid Leukemia Shiyu HeJinxia ZhaoQian Jiang Original Research Article 19 September 2023 Pages: 2413 - 2422
Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier Austin SunJoanne Wang Original Research Article 13 September 2023 Pages: 2667 - 2675
Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease Shih-Yu ChangWeize HuangCatherine K. Yeung Original Research Article 13 September 2023 Pages: 2597 - 2606
Constitutively Synergistic Multiagent Drug Formulations Targeting MERTK, FLT3, and BCL-2 for Treatment of AML James M. KelvinJuhi JainErik C. Dreaden Original Research Article 13 September 2023 Pages: 2133 - 2146
The Use of a Closed Feed Frame for the Development of Near-Infrared Spectroscopic Calibration Model to Determine Drug Concentration Nathaly A. Movilla-MezaNobel O. Sierra-VegaRodolfo J. Romañach Original Research Article 12 September 2023 Pages: 2903 - 2916
Hollow Mesoporous Silica Nanoparticles for Dual Chemo-starvation Therapy of Hepatocellular Carcinoma Aftab UllahMarina KhanDaojun Liu Original Research Article 12 September 2023 Pages: 2215 - 2228
TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation Hannaneh AhmadighadykolaeiJanet A. LambertMaryam Raeeszadeh-Sarmazdeh Original Research Article 12 September 2023 Pages: 2121 - 2131
Strategies to Stabilize Dalbavancin in Aqueous Solutions; Section-1: the Effects of Metal Ions and Buffers Sardar M. JakariaDavid E. BudilJames Murtagh Original Research Article 11 September 2023 Pages: 2469 - 2478
Impact of Apparatus and Adapter on In vitro Drug Release of Ophthalmic Semisolid Drug Products Catheleeya MekjaruskulAndré O’Reilly BeringhsXiuling Lu Original Research Article 07 September 2023 Pages: 2239 - 2251
Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling Jun ZhangYufeng ZhangZhong Zuo Original Research Article 05 September 2023 Pages: 2627 - 2638
Effect of Structurally Related Compounds on Desupersaturation Kinetics of Indomethacin Arushi ManchandaMustafa BookwalaRobin H. Bogner Original Research Article 05 September 2023 Pages: 2769 - 2778
SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters Xavier J. H. PepinIain GrantJ. Matthew Wood Original Research Article Open access 27 August 2023 Pages: 2195 - 2214
Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study Frida BällgrenMargareta Hammarlund-UdenaesIrena Loryan Original Research Article Open access 23 August 2023 Pages: 2715 - 2730
Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing Roman SvobodaMarie NevyhoštěnáAlena Komersová Original Research Article Open access 23 August 2023 Pages: 2253 - 2268
Physiologically Based Pharmacokinetic Modeling for Prediction of 5-FU Pharmacokinetics in Cancer Patients with Hepatic Impairment After 5-FU and Capecitabine Administration Yu WangHaihong HuSu Zeng Original Research Article 23 August 2023 Pages: 2177 - 2194
Oligopeptide/Histidine Transporter PHT1 and PHT2 — Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation Minlei DongPing LiHuidi Jiang Review Article 23 August 2023 Pages: 2585 - 2596
Female is Not First: the Gender Gap in Publishing Means More Needs to be Done Amy Lavelle Editorial 23 August 2023 Pages: 2269 - 2270
Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation Yunjiao WuSwantje VöllerCatherijne A. J. Knibbe Original Research Article Open access 21 August 2023 Pages: 2155 - 2166
Identification of Four Similar Cell Culture Media According to their Glucose, Glutamine, and Pyruvate Content by Handheld Raman Spectroscopy Karla Echeverría-AltamarBárbara B. Alvarado-HernandezRodolfo J. Romañach Original Research Article 18 August 2023 Pages: 2859 - 2871
Is the One-Compartment Model with First Order Absorption a Useful Approximation? Michael Weiss Original Research Article Open access 18 August 2023 Pages: 2147 - 2153
Effect of P-glycoprotein and Cotreatment with Sofosbuvir on the Intestinal Permeation of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Fumarate Martin HuliciakIvona LhotskaLukas Cerveny Original Research Article 18 August 2023 Pages: 2109 - 2120
How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors Wenjuan ZhangJu-Hee OhWilliam F. Elmquist Review Article 17 August 2023 Pages: 2731 - 2746
The Impact of Post-Processing Temperature on PLGA Microparticle Properties Andrew OtteBong Kwan SohKinam Park Original Research Article 17 August 2023 Pages: 2677 - 2685
An Experimental and Computational Approach to Development of Mixing Processes for Miscible Liquids in Unbaffled Tanks Mehrrad SaadatmandMehak MehtaJason E. Fernandez Original Research Article 11 August 2023 Pages: 2087 - 2101
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity Yeamin HuhAnna PlotkaA. David Rodrigues Original Research Article Open access 10 August 2023 Pages: 2639 - 2651
The Relationship Between Molecular Symmetry and Physicochemical Properties Involving Boiling and Melting of Organic Compounds David Humberto LopezSamuel Hyman Yalkowsky Original Research Article 10 August 2023 Pages: 2801 - 2815