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The Molecular Basis of Viral Replication

  • R. Perez Bercoff

Part of the NATO ASI Series book series (NSSA, volume 136)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Viruses at the molecular level

    1. Front Matter
      Pages 1-1
    2. Milton W. Taylor, Howard V. Hershey
      Pages 3-23
    3. Michael G. Rossmann, Edward Arnold, Greg Kamer, Marcia J. Kremer, Ming Luo, Thomas J. Smith et al.
      Pages 25-44
  3. The basic processes involved in viral replication

    1. Front Matter
      Pages 45-45
    2. Howard V. Hershey, Milton W. Taylor
      Pages 47-98
    3. Marie-Dominique Morch, Rosaura P. C. Valle, Anne-Lise Haenni
      Pages 113-159
  4. Interference and interferon

    1. Front Matter
      Pages 161-161
    2. Jean Content
      Pages 163-189
  5. The strategies of replication

    1. Front Matter
      Pages 195-195
    2. R. Perez Bercoff
      Pages 197-215
    3. Brian W. J. Mahy
      Pages 239-254
    4. Suzanne U. Emerson, Manfred Schubert
      Pages 255-276
    5. Daniel Kolakofsky, Laurent Roux
      Pages 277-297
    6. Peter Palese, Deborah A. Buonaugurio
      Pages 299-316
    7. David H. L. Bishop
      Pages 317-326
    8. Malcolm A. McCrae
      Pages 327-353
    9. Giovanni Battista Rossi, Simonetta Pulciani, Maurizio Federico
      Pages 355-413
    10. David A. Shafritz
      Pages 415-435
    11. Peter M. Howley
      Pages 437-456
    12. Arnold J. Levine
      Pages 483-498
    13. Bernard Moss
      Pages 499-516
    14. Bernard Roizman, Frank J. Kenkins, Thomas M. Kristie
      Pages 517-546
  6. Back Matter
    Pages 547-579

About this book

Introduction

the discovery of the "splicing" of the gene transcripts, the list would include the whole molecular genetics of the lambda bacteriophage, the notions of "promotor," "repressor," and "integration," the discovery of the reverse flow of genetic information, the very existence of oncogenes, the S'-terminal "cap" struc­ ture of eukaryotic mRNAs, ... Electronmicroscopy, ultracentrifugation and tissue culture were the landmarks on the way of the young science. During the past few years, however, a major (and not so silent) revolution took place: recombinant DNA technology with all its might entered in our laboratories, and restriction mapping of cloned genomes and sequencing gels have replaced plaque counting and sucrose gradients. The new techniques have made it possible to "dissect" the entire genome of a virus at the molecular level, and studies that would have been dreamt of just in the mid-seventies became the everyday experiments of our days. With new insight into the structure of viral genomes, and a deeper understanding of the mechanisms that regulate their expression, our view of viruses was bound to change: this volume bears witness to this impressive advance.

Keywords

antigen cell cell culture gene gene expression gene regulation genetics genome structure hepatitis B molecular biology molecular genetics oncogenesis proliferation retroviruses virus

Editors and affiliations

  • R. Perez Bercoff
    • 1
  1. 1.The Institute for VirologyUniversity of RomeRomeItaly

Bibliographic information