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Biochemical Aspects of Interferon Action

  • Chapter
The Molecular Basis of Viral Replication

Part of the book series: NATO ASI Series ((NSSA,volume 136))

Abstract

Interferons subtypes are the members of a large family of antiviral substances produced by different animal cells stimulated with viruses or different other inducers (Table 1). Beside their antiviral activity, they behave like pleiotropic hormonal effectors, modifying on the one side the biochemistry of the treated cell at various levels (membrane characteristics, antigen exposure, protein expression, among others), and on the other hand the physiology of the entire organism where they not only behave as part of the immediate defense mechanism against viral infection, but also as potent immunomodulating agents (1, 2) and, in several instances as autocrine regulators implicated in the control of cell growth and differentiation (3, 4).

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Abbreviations

IFN:

Interferon

dsRNA:

double stranded RNA

2–5A:

series of 2′5′ linked oligonucleotides with the general structure pppA(2′p5′A)n with usually n >2

Kd:

dissociation constant

GBP:

guanylate binding protein

DAI:

dsRNA activated inhibitor

Kb:

kilobase

EMC:

encephalomyocarditis virus

VA RNA:

virus associated RNA

EBV:

Epstein-Barr Virus

SV40:

Simian virus 40

VSV:

Vesicular Stomatitis Virus

HSV:

Herpes Simplex Virus

eIF-2:

eukaryotic initiation factor 2

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  1. Department of Virology, Institut Pasteur du Brabant, Rue Engeland 642, B-1180, Bruxelles, Belgium

    Jean Content

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    R. Perez Bercoff

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Content, J. (1987). Biochemical Aspects of Interferon Action. In: Bercoff, R.P. (eds) The Molecular Basis of Viral Replication. NATO ASI Series, vol 136. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5350-8_6

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