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Biochemical Aspects of Interferon Action

  • Jean Content
Part of the NATO ASI Series book series (NSSA, volume 136)

Abstract

Interferons subtypes are the members of a large family of antiviral substances produced by different animal cells stimulated with viruses or different other inducers (Table 1). Beside their antiviral activity, they behave like pleiotropic hormonal effectors, modifying on the one side the biochemistry of the treated cell at various levels (membrane characteristics, antigen exposure, protein expression, among others), and on the other hand the physiology of the entire organism where they not only behave as part of the immediate defense mechanism against viral infection, but also as potent immunomodulating agents (1, 2) and, in several instances as autocrine regulators implicated in the control of cell growth and differentiation (3, 4).

Keywords

Vaccinia Virus Daudi Cell Antiviral State Guanylate Binding Protein Interferon System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of abbreviations

IFN

Interferon

dsRNA

double stranded RNA

2–5A

series of 2′5′ linked oligonucleotides with the general structure pppA(2′p5′A)n with usually n >2

Kd

dissociation constant

GBP

guanylate binding protein

DAI

dsRNA activated inhibitor

Kb

kilobase

EMC

encephalomyocarditis virus

VA RNA

virus associated RNA

EBV

Epstein-Barr Virus

SV40

Simian virus 40

VSV

Vesicular Stomatitis Virus

HSV

Herpes Simplex Virus

eIF-2

eukaryotic initiation factor 2

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Jean Content
    • 1
  1. 1.Department of VirologyInstitut Pasteur du BrabantBruxellesBelgium

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