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The Replication of Togaviridae and Flaviviridae at the Molecular Level

  • Milton J. Schlesinger
Part of the NATO ASI Series book series (NSSA, volume 136)

Abstract

Until quite recently, the small enveloped viruses that contain single stranded (+) RNA (their genome is infectious and serves as an mRNA) were grouped into the Togaviridae family, with two major subgroups noted as alphaviruses and flaviviruses. With the elucidation of the genomic sequence of the Yellow Fever virus and additional knowledge of the structure and replication of the flaviviruses, it became clear that these viruses should be placed into a family distinct from that of the Togaviridae. Even so, the viruses in these two families share a number of properties and many lead to similar pathologies upon infection of mammalian hosts. Most of the members of these families were previously noted as arboviruses (acronym from “arthropod borne”) since a portion of their natural life cycle involves growth in an arthropod vector. There are a very large number of species within these families with genotypically and serologically distinct isolates obtained throughout the world. A thorough description of the epidemiology of these viruses can be found in the Togaviruses: Biology, Structure, Replication (1).

Keywords

Chicken Embryo Fibroblast Semliki Forest Virus Sindbis Virus Yellow Fever Virus Virus Nonstructural Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Milton J. Schlesinger
    • 1
  1. 1.Department of Microbiology and ImmunologyWashington University School of MedicineSt. LouisUSA

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