The Molecular Biology of Arenaviruses
Five families of viruses are recognized as negative-stranded RNA viruses. These are the Arenaviridae, Bunyaviridae, Orthomyxoviridae, Paramyxoviridae and Rhabdoviridae. All have a lipid envelope, an external fringe of glycoprotein and internal components consisting of one or more species of single-stranded RNA in addition to structural proteins and RNA polymerase components. The RNA species of negative-stranded viruses are not infectious per se since the infection process of each of these viruses requires that the virion polymerase transcribes the viral RNA into complementary mRNA species before the infection can proceed. Therefore removal of viral protein from the RNA of these viruses eliminates the required enzymes and renders the RNA non-infectious.
KeywordsmRNA Species Lassa Fever Lipid Envelope Argentine Hemorrhagic Fever External Fringe
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