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Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

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Abstract

The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.

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  1. Mi Na Rhie and Hee Taek Kim equally contributed to this work.

Authors and Affiliations

  1. Division of Chemical Engineering and Materials Science, Ewha Womans University, Seoul, 03760, Korea

    Mi Na Rhie, Seo Young Jo, Luan Luong Chu, Kei-Anne Baritugo, Mary Grace Baylon & Si Jae Park

  2. Bio-based Chemistry Research Center, Advanced Convergent Chemistry Division, Korea Research Institute of Chemical Technology, Daejeon, 34602, Korea

    Hee Taek Kim & Jeong Chan Joo

  3. Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, 04107, Korea

    Jinwon Lee, Jeong-Geol Na & Lyul Ho Kim

  4. Department of Biotechnology and Bioengineering, Chonnam National University, Gwangju, 61186, Korea

    Tae Wan Kim

  5. Department of Chemical Engineering, Kwangwoon University, Seoul, 01897, Korea

    Chulhwan Park

  6. Department of Chemical Engineering, University of Ulsan, Ulsan, 44610, Korea

    Soon Ho Hong

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  1. Mi Na Rhie
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Correspondence to Jeong Chan Joo or Si Jae Park.

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Rhie, M.N., Kim, H.T., Jo, S.Y. et al. Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries. Biotechnol Bioproc E 24, 48–64 (2019). https://doi.org/10.1007/s12257-018-0346-x

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  • DOI: https://doi.org/10.1007/s12257-018-0346-x

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