Articles

1. Evaluating the Pharmacokinetics of Fentanyl in the Brain Extracellular Fluid, Saliva, Urine, and Plasma of Newborns from Transplacental Exposure from Parturient Mothers Dosed with Epidural Fentanyl Utilizing PBPK Modeling

   • Mo’tasem M. Alsmadi

   Original Research Article 10 August 2023 Pages: 567 - 586

   

2. Preclinical Pharmacokinetics and in vitro Metabolism of FHND5071, a Novel Selective RET Kinase Inhibitor

   • Yiran Han
   • Tiantian Wen
   • Yongqiang Zhu

   Original Research Article 02 August 2023 Pages: 595 - 614

   

3. First-in-Human Study of the Safety, Pharmacokinetics, and Pharmacodynamics of MHV370, a Dual Inhibitor of Toll-Like Receptors 7 and 8, in Healthy Adults

   • Tamas Shisha
   • Maximilian G. Posch
   • Peter Gergely

   Original Research Article Open access 02 August 2023 Pages: 553 - 566

   

4. A Quantitative Prediction Method for the Human Pharmacokinetics of Fc-Fusion Proteins

   • Miki Yokoyama
   • Eiko Suzuki
   • Nobuaki Watanabe

   Original Research Article 02 August 2023 Pages: 541 - 552

   

5. Nano Drug Delivery Strategies for an Oral Bioenhanced Quercetin Formulation

   • Esha S. Attar
   • Vanashree H. Chaudhari
   • Padma V. Devarajan

   Review Article 31 July 2023 Pages: 495 - 514

   

6. Dried Blood Spots—A Platform for Therapeutic Drug Monitoring (TDM) and Drug/Disease Response Monitoring (DRM)

   • Nur Nabihah Binte Zailani
   • Paul Chi-Lui Ho

   Review Article Open access 26 July 2023 Pages: 467 - 494

   

7. Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults

   • Kannan Sridharan
   • Mwila Mulubwa
   • Ali Mohamed Qader

   Original Research Article 30 June 2023 Pages: 531 - 540

   

8. Monitoring Salivary Concentrations of Tedizolid and Linezolid Using Rats

   • Yuki Inoue
   • Yuki Sato
   • Yoh Takekuma

   Original Research Article 27 June 2023 Pages: 387 - 395

   

9. Metabolism and Disposition of the Novel Oral Factor XIa Inhibitor Asundexian in Rats and in Humans

   • Isabel Piel
   • Anna Engelen
   • Friederike Kanefendt

   Original Research Article Open access 26 June 2023 Pages: 411 - 425

   

10. Pharmacokinetics and Drug–Drug Interaction of Ocedurenone (KBP-5074) in vitro and in vivo

    • Ping Wang
    • Jinrong Liu
    • Jay Zhang

    Original Research Article Open access 25 June 2023 Pages: 397 - 410

    

11. Cefiderocol is Not Sequestered in an Ex Vivo Extracorporeal Membrane Oxygenation (ECMO) Circuit

    • Angela V. Berry
    • Allison Conelius
    • Joseph L. Kuti

    Original Research Article 23 June 2023 Pages: 437 - 441

    

12. Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma

    • Yu Zhuang
    • Yuxiao Wang
    • Zhixia Qiu

    Original Research Article 21 June 2023 Pages: 363 - 376

    

13. Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products

    • Erin C. Berthold
    • Shyam H. Kamble
    • Abhisheak Sharma

    Original Research Article 19 June 2023 Pages: 427 - 435

    

14. Early At-Home Measurement of Adalimumab Concentrations to Guide Anti-TNF Precision Dosing: A Pilot Study

    • Paul A. G. de Klaver
    • Ron J. Keizer
    • Luc J. J. Derijks

    Original Research Article 15 June 2023 Pages: 377 - 385

    

15. Management of Drug Interactions with Inducers: Onset and Disappearance of Induction on Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyltransferase 1A1 Substrates

    • Sara Bettonte
    • Mattia Berton
    • Catia Marzolini

    Original Research Article Open access 06 June 2023 Pages: 353 - 362

    

16. Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept

    • Athanasios A. Tsekouras
    • Panos Macheras

    Short Communication 02 June 2023 Pages: 455 - 462

    

17. Development of a 2D-QSAR Model for Tissue-to-Plasma Partition Coefficient Value with High Accuracy Using Machine Learning Method, Minimum Required Experimental Values, and Physicochemical Descriptors

    • Koichi Handa
    • Seishiro Sakamoto
    • Takeshi Iijima

    Original Research Article 02 June 2023 Pages: 341 - 352

    

18. Pharmacokinetic Study of ¹⁴C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model

    • Tsubasa Watanabe
    • Tomohiro Yoshikawa
    • Minoru Suzuki

    Original Research Article 18 May 2023 Pages: 443 - 453

    

19. Clinical Pharmacokinetics of Radiopharmaceuticals from SPECT/CT Image Acquisition by Contouring in Patients with Gastroenteropancreatic Neuroendocrine Tumors: Lu-177 DOTATATE (Lutathera^®) Case

    • Anissa Barakat
    • Lore Santoro
    • Sonia Khier

    Original Research Article 15 May 2023 Pages: 329 - 339

    

20. In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes

    • Mohammad Zafar Imam
    • Sussan Ghassabian
    • Maree T. Smith

    Research Letter 12 May 2023 Pages: 463 - 466

    

21. Role of Cytochrome P450 2C9 in COVID-19 Treatment: Current Status and Future Directions

    • Sharoen Yu Ming Lim
    • Basel Al Bishtawi
    • Willone Lim

    Review Article 24 April 2023 Pages: 221 - 240

    

22. Pharmacokinetics of N,N-dimethyltryptamine in Humans

    • Meghan Good
    • Zelah Joel
    • Ellen James

    Original Research Article Open access 22 April 2023 Pages: 311 - 327

    

23. Comparative Study on the Pharmacokinetics of Paeoniflorin, White Peony Root Water Extract, and Taohong Siwu Decoction After Oral Administration in Rats

    • Wei-chun Chen
    • Xiao-yi Liang
    • Wei-rong Li

    Original Research Article 20 April 2023 Pages: 301 - 310

    

24. The Analysis of Pethidine Pharmacokinetics in Newborn Saliva, Plasma, and Brain Extracellular Fluid After Prenatal Intrauterine Exposure from Pregnant Mothers Receiving Intramuscular Dose Using PBPK Modeling

    • Mo’tasem M. Alsmadi
    • Nasir Idkaidek

    Original Research Article 05 April 2023 Pages: 281 - 300

    

25. Relationship Between Serum Ustekinumab Trough Concentration and Clinical and Biochemical Disease Activity: A Real-World Study in Adult Patients with Crohn’s Disease

    • Khue M. Nguyen
    • Vandita Y. Mattoo
    • Emily K. Wright

    Original Research Article 23 March 2023 Pages: 271 - 279

    

26. Population Pharmacokinetic and Pharmacodynamic Modeling of Fesoterodine in Pediatric Patients with Neurogenic Detrusor Overactivity

    • Yamato Sano
    • Satoshi Shoji
    • Bimal K Malhotra

    Original Research Article Open access 09 March 2023 Pages: 257 - 269

    

27. Predictive Potential of BCS and Pharmacokinetic Parameters on Study Outcome: Analysis of 198 In Vivo Bioequivalence Studies

    • Dejan Krajcar
    • Iztok Grabnar
    • Jerneja Opara

    Original Research Article Open access 05 March 2023 Pages: 241 - 255

    

28. Population Pharmacokinetic Model for Unbound Concentrations of Daptomycin in Patients with MRSA Including Patients Undergoing Hemodialysis

    • Saki Takahashi
    • Yasuhiro Tsuji
    • Yoshihiro Yamamoto

    Original Research Article 02 March 2023 Pages: 201 - 211

    

29. Neurotherapeutic Effects of Quercetin and Its Metabolite Compounds on Cognitive Impairment and Parkinson’s Disease: An In Silico Study

    • Hai Duc Nguyen

    Original Research Article 27 February 2023 Pages: 151 - 169

    

30. Characterization of the Stereoselective Disposition of Bupropion and Its Metabolites in Rat Plasma and Brain

    • Chandrali S. Bhattacharya
    • Andrea R. Masters
    • Robert E. Stratford Jr.

    Original Research Article 23 February 2023 Pages: 171 - 187

    

31. A Pharmacokinetic, Safety, and Tolerability Trial of Palovarotene in Healthy Japanese and Non-Japanese Participants

    • Louise Dube
    • Nobuhiko Haga
    • Kim-Hanh Le Quan Sang

    Original Research Article Open access 18 February 2023 Pages: 141 - 150

    

32. Enhanced Pharmacokinetics and Anti-inflammatory Activity of Curcumin Using Dry Emulsion as Drug Delivery Vehicle

    • Mahesh Nayakula
    • Manish Kumar Jeengar
    • Naveen Chella

    Original Research Article 17 February 2023 Pages: 189 - 199

    

33. Response to Comment on “Interchangeability Between Generic and Reference Products: Limits of Average Bioequivalence Methodology”

    • Philippe Lechat

    Letter to the Editor (invited) 21 January 2023 Pages: 217 - 219

34. Comment on “Interchangeability between Generic and Reference Products: Limits of Average Bioequivalence Methodology”

    • Patrick Nicolas
    • Xavier Bertagna

    Letter to the Editor 21 January 2023 Pages: 213 - 215

35. Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets

    • Michael Weiss

    Original Research Article Open access 16 January 2023 Pages: 133 - 140

    

36. Pharmacokinetic Interaction of Anaprazole, Amoxicillin and Clarithromycin after Single-Dose Simultaneous Administration and the Effect of Adding Bismuth on Their Pharmacokinetics in Healthy Male Chinese Subjects

    • Sijia Ding
    • Lijun Xie
    • Feng Shao

    Original Research Article 15 December 2022 Pages: 121 - 132

    

37. Correction to: Evaluating Islatravir Administered Via Microneedle Array Patch for Long-Acting HIV Pre-exposure Prophylaxis Using Physiologically Based Pharmacokinetic Modelling

    • Hannah Kinvig
    • Nicolas Cottura
    • Marco Siccardi

    Correction Open access 14 December 2022 Pages: 119 - 119

38. Population Pharmacokinetic–Pharmacodynamic Modeling and Probability of Target Attainment Analysis of Rocuronium and Sugammadex in Children Undergoing Surgery

    • Małgorzata Grześkowiak
    • Agnieszka Bienert
    • Alicja Bartkowska-Śniatkowska

    Original Research Article Open access 08 December 2022 Pages: 101 - 114

    

39. Population Pharmacokinetic Analysis for Model-Based Therapeutic Drug Monitoring of Tacrolimus in Chinese Han Heart Transplant Patients

    • Yu Cheng
    • Jiana Chen
    • Jinhua Zhang

    Original Research Article 08 December 2022 Pages: 89 - 100

    

40. Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant

    • Klaus Francke
    • Niladri Chattopadhyay
    • Christian Friedrich

    Original Research Article 05 December 2022 Pages: 75 - 87

    

41. Plasma Protein Binding Refinement of the Extended Clearance Classification System: Subclasses for Predicting Hepatic Uptake or Renal Clearance for Classes 1B and 3B

    • Yahya Khawaja
    • Fatma Haddad
    • Hussein Hallak

    Original Research Article 28 November 2022 Pages: 63 - 73

    

42. Pharmacokinetic Interactions and Tolerability of Rosuvastatin and Ezetimibe: A Randomized, Phase 1, Crossover Study in Healthy Chinese Participants

    • Lu Wang
    • Yingcai Luan
    • Jie Hou

    Original Research Article Open access 27 November 2022 Pages: 51 - 62

    

43. Therapeutic Drug Monitoring of Lacosamide in Chinese Pediatric Patients with Epilepsy: Efficacy and Factors Influencing the Plasma Concentration

    • Ting Zhao
    • Hong-jian Li
    • Lu-hai Yu

    Original Research Article 23 November 2022 Pages: 41 - 49

    

44. Pharmacokinetics and Safety of Vedolizumab Following Administration of a Single Intravenous Dose in Healthy Chinese Subjects

    • Ran Xie
    • Nan Zhao
    • Alexander Prokopienko

    Original Research Article Open access 18 November 2022 Pages: 35 - 40

    

45. Hepatic Transporters Alternations Associated with Non-alcoholic Fatty Liver Disease (NAFLD): A Systematic Review

    • Navid Omidkhoda
    • Simin zare
    • Amir Hooshang Mohammadpour

    Systematic Review 02 November 2022 Pages: 1 - 10

    

46. Acknowledgement to Referees

    ACKNOWLEDGEMENT TO REFEREES 31 October 2022 Pages: 757 - 759

47. Effect of Carbidopa Dose on Levodopa Pharmacokinetics With and Without Catechol-O-Methyltransferase Inhibition in Healthy Subjects

    • Johanna Tuunainen
    • Noora Sjöstedt
    • Marjo Yliperttula

    Original Research Article 30 October 2022 Pages: 23 - 34

    

48. Rapid Brain Distribution of Subcutaneously Administered Methamphetamine in Mice

    • Greg Gorman
    • Lori Coward
    • Michael D. Hambuchen

    Research Letter 26 October 2022 Pages: 115 - 118

    

49. Population Pharmacokinetics and Dosing Simulations of Intravenous Oxycodone for Perioperative Pain Relief in Adult Surgical Patients with Obesity

    • Sook Hui Chaw
    • Yoke Lin Lo
    • Ina Ismiarti Shariffuddin

    Original Research Article 07 October 2022 Pages: 11 - 21

    

50. Involvement of Autophagy in the Protective Effects of Ginsenoside Rb1 in a Rat Model of Traumatic Brain Injury

    • Shufeng Zou
    • Wei Chen
    • Jiugeng Feng

    Original Research Article 05 October 2022 Pages: 869 - 877