Collection
Exploring the molecular mechanisms of infectious microbes and/or the microbiota in chronic neurologic and psychiatric diseases.
- Submission status
- Open
- Open for submission from
- 08 February 2023
- Submission deadline
- Ongoing
The most prevalent driver of inflammation in the human body is infection, however microbes’ role in chronic neuro-inflammation is a decades-old yet controversial topic gaining new traction, due in part to the COVID-19 pandemic. A number of neurologic and psychiatric diseases involve neuro-inflammation, and numerous infectious microbes are capable of entering the brain proper and inducing this state. Microbes that do not directly invade the brain such as those in the gut, can also indirectly induce inflammation through multiple mechanisms. Various brain diseases ranging from Dementia, Alzheimer’s disease, Parkinson’s disease, Frontotemporal Dementia, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Depression, Anxiety, Post Traumatic Stress Disorder, Obsessive Compulsive Disorder, and Schizophrenia (among others) have been associated with microbial infection or microbiome perturbations, but a causal role remains elusive.
The range of microbes associated with chronic neuro-inflammatory and psychiatric diseases is diverse. Viruses, bacteria, fungi, and parasites have all been linked to neurologic and/or psychiatric diseases by epidemiological studies, retrospective evaluations, post-mortem analyses, and through cellular and animal modeling. SARS-CoV2 has joined this list of microbes, resulting in varied neurologic and psychiatric presentations of chronicity in vulnerable patients. Emerging research documents Alzheimer’s-like pathology (amyloid-beta deposition), brain shrinkage, and at times, detection of viable, live virus in post-mortem brain tissues of patients who died from COVID-19. In this special issue, we invite the scientific community to submit original research papers, reviews, meta-analyses, etc pertaining to the molecular mechanisms of neurologic and psychiatric diseases with emphasis on infectious microbes (the pathobiota) and/or the alterations to the microbiota that may lead to these disease states.
Editors
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Brian J. Balin
Dr. Balin is the Director of the Center for Chronic Disorders of Aging – Basic Science at the Philadelphia College of Osteopathic Medicine. He is the Chair of the Department of Bio-Medical Sciences and Professor of Neuroscience and Neuropathology. Dr. Balin is an internationally-recognized expert in the field of Alzheimer’s Disease research.
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Nikki M. Schultek
A passionate advocate and innovator shedding light on the role of chronic infections in devastating human diseases, with emphasis on neurodegeneration, Alzheimer's, and Asthma. Building research collaborations, advising companies innovating around chronic infection, publishing alongside global experts, and pursuing basic questions about the origin of disease.
Articles (42 in this collection)
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Adeno-associated Virus-mediated Ezh2 Knockdown Reduced the Increment of Newborn Neurons Induced by Forebrain Ischemia in Gerbil Dentate Gyrus
Authors (first, second and last of 8)
- Yoshihide Sehara
- Yuki Hashimotodani
- Hiroaki Mizukami
- Content type: Research
- Open Access
- Published: 27 April 2024
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Aberrant Enhanced NLRP3 Inflammasomes and Cell Pyroptosis in the Brains of Prion-Infected Rodent Models Are Largely Associated with the Proliferative Astrocytes
Authors (first, second and last of 11)
- Dong-Hua Zhou
- Xiao-Xi Jia
- Qi Shi
- Content type: Research
- Published: 26 April 2024
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Bioinformatics Approach to Identify the Pathogenetic Link of Gut Microbiota-Derived Short-Chain Fatty Acids and Ischemic Stroke
Authors (first, second and last of 6)
- Liang Ding
- Jianing Wang
- Pengpeng An
- Content type: Research
- Open Access
- Published: 22 April 2024
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Research Hotspots and Frontiers of Alzheimer’s Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis
Authors (first, second and last of 4)
- Youao Zhang
- Zixuan Jia
- Hui Liang
- Content type: Research
- Published: 18 April 2024
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Transactivator of Transcription (Tat)-Induced Neuroinflammation as a Key Pathway in Neuronal Dysfunction: A Scoping Review
Authors
- Tshengedzeni Muvenda
- Aurelia A. Williams
- Monray Edward Williams
- Content type: Review
- Open Access
- Published: 17 April 2024
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The Impact of Prevotella on Neurobiology in Aging: Deciphering Dendritic Cell Activity and Inflammatory Dynamics
Authors
- H Shafeeq Ahmed
- Content type: Review
- Published: 13 April 2024
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The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease
Authors (first, second and last of 4)
- Liyan Yao
- Yong Yang
- Mohammad J. Rezaei
- Content type: Review
- Published: 08 April 2024
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Astaxanthin and DHA Supplementation Modulates the Maternal Undernutrition-induced Impairment of Cognitive Behavior and Synaptic Plasticity in Adult Life of Offspring’s -Exploring the Molecular Mechanism
Authors (first, second and last of 5)
- Megha Bhat Agni
- Pramukh Subrahmanya Hegde
- Damodara Gowda K M
- Content type: Research
- Published: 05 April 2024
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Post-COVID-19 Hyposmia Does Not Exhibit Main Neurodegeneration Markers in the Olfactory Pathway
Authors (first, second and last of 17)
- Tommaso Schirinzi
- Daniela Maftei
- Cinzia Severini
- Content type: Research
- Open Access
- Published: 04 April 2024
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PD-Like Pathogenesis in Caenorhabditis elegans Intestinally Infected with Nocardia farcinica and the Underlying Molecular Mechanisms
Authors (first, second and last of 10)
- Wenwen Liu
- Wenhui Zhou
- Xiaowei Huang
- Content type: Research
- Published: 28 March 2024
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Causal Relationships Between Gut Microbiota, Inflammatory Cells/Proteins, and Subarachnoid Hemorrhage: A Multi-omics Bidirectional Mendelian Randomization Study and Meta-analysis
Authors
- Congzhi Yan
- Yun Li
- Content type: Research
- Published: 25 March 2024
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High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
Authors (first, second and last of 9)
- Jingfang Lin
- Dong Zheng
- Honghao Wang
- Content type: Research
- Published: 20 March 2024
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Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H2O2-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans
Authors (first, second and last of 10)
- Shaojun Wu
- Jie Miao
- Hao Yang
- Content type: Research
- Published: 14 March 2024
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Exosomes Derived from Meningitic Escherichia coli–Infected Brain Microvascular Endothelial Cells Facilitate Astrocyte Activation
Authors (first, second and last of 8)
- Ruicheng Yang
- Xinyi Qu
- Xiangru Wang
- Content type: Research
- Published: 19 February 2024
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COVID-19, Anxiety, and Body Mass Index Increase Leptin Levels: a Cross-sectional Multicentric Study
Authors (first, second and last of 19)
- Gislaine Z. RĂ©us
- Kelen C. C. Recco
- Taiane de Azevedo Cardoso
- Content type: OriginalPaper
- Published: 20 December 2023
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Drug-Resistant Epilepsy and Gut-Brain Axis: an Overview of a New Strategy for Treatment
Authors (first, second and last of 6)
- Shuna Chen
- Yang Jiao
- Jing Liu
- Content type: ReviewPaper
- Published: 12 December 2023
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Effects of Intestinal M Cells on Intestinal Barrier and Neuropathological Properties in an AD Mouse Model
Authors (first, second and last of 7)
- Shijing Wu
- Li Hu
- Zhou Liu
- Content type: OriginalPaper
- Published: 08 December 2023
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Role of Maternal Immune Factors in Neuroimmunology of Brain Development
Authors (first, second and last of 6)
- Mehdi Mohebalizadeh
- Golsa Babapour
- Vahid Shafiei-Irannejad
- Content type: ReviewPaper
- Published: 07 December 2023
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High Levels of NfL, GFAP, TAU, and UCH-L1 as Potential Predictor Biomarkers of Severity and Lethality in Acute COVID-19
Authors (first, second and last of 18)
- Andreza Lemos Salvio
- Renan Amphilophio Fernandes
- Soniza Vieira Alves-Leon
- Content type: OriginalPaper
- Open Access
- Published: 24 November 2023
- Pages: 3545 - 3558
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Microbiota Alters and Its Correlation with Molecular Regulation Underlying Depression in PCOS Patients
Authors (first, second and last of 5)
- Liying Yu
- Xiaoyu Chen
- Ming Sui
- Content type: OriginalPaper
- Published: 23 November 2023
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Intestinal Microbiota Is a Key Target for Load Swimming to Improve Anxiety Behavior and Muscle Strength in Shank 3-/- Rats
Authors (first, second and last of 5)
- Shasha An
- Zhiping Zhen
- Shuai Zhang
- Content type: OriginalPaper
- Published: 15 November 2023
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Does COVID-19 Trigger the Risk for the Development of Parkinson’s Disease? Therapeutic Potential of Vitamin C
Authors
- Sandeep
- Rhea Subba
- Amal Chandra Mondal
- Content type: ReviewPaper
- Published: 14 November 2023
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Interplay Between Zika Virus-Induced Autophagy and Neural Stem Cell Fate Determination
Authors
- Bindu
- Hriday Shanker Pandey
- Pankaj Seth
- Content type: OriginalPaper
- Published: 01 November 2023
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SARS-CoV-2 Spike Protein S1 Domain Accelerates α-Synuclein Phosphorylation and Aggregation in Cellular Models of Synucleinopathy
Authors (first, second and last of 6)
- Jiannan Wang
- Lijun Dai
- Zhentao Zhang
- Content type: OriginalPaper
- Published: 28 October 2023
- Pages: 2446 - 2458
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Brain Fog: a Narrative Review of the Most Common Mysterious Cognitive Disorder in COVID-19
Authors
- Mahsa Aghajani Mir
- Content type: ReviewPaper
- Published: 24 October 2023
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Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety
Authors (first, second and last of 4)
- Gouri Jadhav
- Biru B. Dudhabhate
- Amul J. Sakharkar
- Content type: OriginalPaper
- Published: 23 October 2023
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Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases
Authors (first, second and last of 5)
- Ieshita Pan
- Praveen Kumar Issac
- Jesu Arockiaraj
- Content type: ReviewPaper
- Published: 18 October 2023
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Comprehensive Risk Assessment of Infection Induced by SARS-CoV-2
Authors (first, second and last of 7)
- KB. Megha
- S. Reshma
- PV. Mohanan
- Content type: ReviewPaper
- Published: 11 October 2023
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What Is the Impact of the Novel Coronavirus and the Vaccination on Guillain–Barre Syndrome?
Authors (first, second and last of 7)
- Yinuo Chen
- Kezheng Li
- Binbin Deng
- Content type: ReviewPaper
- Published: 20 September 2023
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Accumulation of Prion Triggers the Enhanced Glycolysis via Activation of AMKP Pathway in Prion-Infected Rodent and Cell Models
Authors (first, second and last of 13)
- Qin Fan
- Kang Xiao
- Xiao-Ping Dong
- Content type: OriginalPaper
- Published: 20 September 2023
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Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19
Authors
- Alessanda S. Rieder
- Angela T. S. Wyse
- Content type: ReviewPaper
- Published: 29 August 2023
- Pages: 581 - 592
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An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life
Authors (first, second and last of 16)
- Kolade Oluwagbemigun
- Andrea Anesi
- Ute Nöthlings
- Content type: OriginalPaper
- Open Access
- Published: 22 August 2023
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Gut Microbiota Metabolites Mediate Bax to Reduce Neuronal Apoptosis via cGAS/STING Axis in Epilepsy
Authors (first, second and last of 8)
- Jinxia Zhai
- Chao Wang
- Yongjun Chen
- Content type: OriginalPaper
- Published: 22 August 2023
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NLRP3 Activation Contributes to Memory Impairment in an Experimental Model of Pneumococcal Meningitis
Authors (first, second and last of 8)
- Jaqueline S. Generoso
- Cristiano Julio Faller
- Vijayasree V. Giridharan
- Content type: OriginalPaper
- Published: 21 August 2023
- Pages: 239 - 251
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Matrine Mediated Immune Protection in MS by Regulating Gut Microbiota and Production of SCFAs
Authors (first, second and last of 12)
- Mengmeng Dou
- Yaojuan Chu
- Lin Zhu
- Content type: OriginalPaper
- Published: 15 August 2023
- Pages: 74 - 90
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Abnormal Changes of IL3/IL3R and Its Downstream Signaling Pathways in the Prion-Infected Cell Line and in the Brains of Scrapie-Infected Rodents
Authors (first, second and last of 12)
- Xiao-Xi Jia
- Cao Chen
- Xiao-Ping Dong
- Content type: OriginalPaper
- Published: 07 August 2023
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The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke
Authors (first, second and last of 4)
- Meiqin Zeng
- Meichang Peng
- Haitao Sun
- Content type: ReviewPaper
- Published: 27 July 2023
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Recombinant SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Stimulate Release of Different Pro-Inflammatory Mediators via Activation of Distinct Receptors on Human Microglia Cells
Authors
- Irene Tsilioni
- Theoharis C. Theoharides
- Content type: OriginalPaper
- Published: 21 July 2023
- Pages: 6704 - 6714
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The Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy
Authors (first, second and last of 4)
- Megan Dubowsky
- Frances Theunissen
- Mary-Louise Rogers
- Content type: ReviewPaper
- Open Access
- Published: 14 July 2023
- Pages: 6330 - 6345
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Conservation of vCJD Strain Properties After Extraction and In Vitro Propagation of PrPSc from Archived Formalin-Fixed Brain and Appendix Tissues Using Highly Sensitive Protein Misfolding Cyclic Amplification
Authors (first, second and last of 12)
- Suzanne Suleiman
- Lynne I. McGuire
- Marcelo A. Barria
- Content type: OriginalPaper
- Open Access
- Published: 13 July 2023
- Pages: 6275 - 6293
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Microbiota Metabolites and Immune Regulation Affect Ischemic Stroke Occurrence, Development, and Prognosis
Authors (first, second and last of 7)
- Tao Wang
- Chuanling Pan
- Caiyan Xin
- Content type: ReviewPaper
- Published: 11 July 2023
- Pages: 6176 - 6187