Skip to main content

Arterial Histochemistry in Relation to Structure, Function and Disease

  • Chapter
Structure and Function of the Circulation

Abstract

Perhaps both the editor and author were misguided in giving this chapter the title of Arterial Histochemistry, for histochemical methods cannot be applied in a vacuum without reference to other methods and to particular topics or problems. For this reason this chapter is not a review of histochemistry, but aims rather to show how histochemical, cytochemical and microchemical methods have contributed inter alia to the investgation of the normal structure, development and disease of the arterial wall.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abdulla, Y.H., and Adams, C.W.M., 1965, The distribution and nature of phospholipids in the human aortic wall. J. Atheroscler. Res., 5:504.

    Article  Google Scholar 

  • Abdulla, Y.H., Adams, C.W.M., Morgan, R.S., 1967, Connective-tissue reactions to implantation of purified sterol, sterol esters, phosphoglycerides, glycerides and free fatty acids. J. Path. Bact., 94:63.

    Article  Google Scholar 

  • Abdulla, Y.H., Adams, C.W.M., and Morgan, R.S., 1969a, Differential resorption rates of subcutaneous implants of (3H) cholesterol-(−14C) linolenate. J. Atheroscler. Res., 9:81.

    Article  Google Scholar 

  • Abdulla, Y.H., Adams. C.W.M., and Bayliss, O.B., 1969b, Relative absence of triglycerides in coronary atherosclerotic lesions. J. Atheroscler. Res., 10:149.

    Article  Google Scholar 

  • Abdulla, Y.H., and Adams, C.W.M., 1978, The action of human high density lipoprotein on cholesterol crystals. Part 2: Biochemical observations. Atherosclerosis, 31:473–480.

    Article  Google Scholar 

  • Adams, C.W.M., 1956, A stricter interpretation of the ferric ferri-cyanide reaction with particular reference to the demonstrat-tion of protein-bound sulphydryl and disulphide groups. J. Histochem. Cytochem., 4:23.

    Article  Google Scholar 

  • Adams, C.W.M., 1957, A p-dimethylaminobenzaldehyde-nitrite method for the histochemical demonstration of tryptophan and related compounds. J. Clin. Path., 10:56.

    Article  Google Scholar 

  • Adams, C.W.M., 1959a, Role of lipids of aortic elastic fibers in atherogenesis. Lancet, i:1075.

    Article  Google Scholar 

  • Adams, C.W.M., 1959b, A histochemical method for the simultaneous demonstration of normal and degenerating myelin. J. Path. Bact., 77:648.

    Article  Google Scholar 

  • Adams, C.W.M., 1961a, Atherosclerosis and coronary occlusion. Lancet, i:555.

    Article  Google Scholar 

  • Adams, C.W.M., 1961b, A perchloric acid-naphthoquinone method for the histochemical localization of cholesterol. Nature (Lond.), 192:331.

    Article  ADS  Google Scholar 

  • Adams, C.W.M., and Tuqan, N.A., 1961, Elastic degeneration as source of lipids in the early lesion of atherosclerosis. J. Path. Bact., 82:131.

    Article  Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1962, The release of protein, lipid and polysaccharide components of the arterial elastica by proteolytic enzymes and lipid solvents. J. Histochem. Cytochem., 10:222.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Ibrahim, M.Z.M., 1962, A hypothesis to explain the accumulation of cholesterol in atherosclerosis. Lancet, i:890.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Ibrahim, M.Z.M., 1963a, The distribution of lipids and enzymes in the aortic wall in dietary rabbit atheroma and human atherosclerosis. J. Path. Bact., 86:421.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Ibrahim, M.Z.M., 1963b, Modifications to histochemical methods for phosphoglyceride and cere-broside. J. Histochem. Cytochem., 11:560.

    Article  Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1963, Histochemical observations on the localisation and origin of sphingomyelin, cerebroside and cholesterol in the normal and atherosclerotic human artery. J. Path. Bact., 85:113.

    Article  Google Scholar 

  • Adams, C.W.M., 1964a, Arteriosclerosis in man, other mammals and birds. Biol. Rev., 39:372.

    Article  Google Scholar 

  • Adams, C.W.M., 1964b, Histochemical studies on the distribution of lipids and enzymes in the normal and atherosclerotic artery, in “Symposium on Biological Aspects of Occlusive Vascular Disease.” (D.G. Chalmers and G.A. Gresham, eds.) pp. 41–45, Cambridge University Press, London.

    Google Scholar 

  • Adams, C.W.M., 1965, Neurohistochemistry. Elsevier, Amsterdam.

    Google Scholar 

  • Adams, C.W.M., and Morgan, R.S., 1966, Autoradiographic demonstration of cholesterol filtration and accumulation in atheromatous rabbit aorta. Nature (Lond.), 210:175.

    Article  ADS  Google Scholar 

  • Adams, C.W.M., and Weller, R.O., 1966, Phospholipids in atherosclerotic lesions in mammals and birds: light-and electron-histochemical studies. Acta. Zool. Path., Antwerp, 39:27.

    Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Orton, C.C., 1967a, Zonal increase in lactic dehydrogenase activity in the senescent human aorta. J. Atheroscler. Res., 7:567.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Orton, C.C., 1967b, Plasma protein accumulation in arterial degenerations. J. Atheroscler. Res., 7:473.

    Article  Google Scholar 

  • Adams, C.W.M., 1967, “Vascular Histochemistry.” Lloyd-Luke, London.

    Google Scholar 

  • Adams, C.W.M., Orton, C.C., and Zilkha, K.J., 1968a, Arterial catecholamine and enzyme histochemistry in migraine. J. Neurol. Neurosurg. Psychiat., 31:50.

    Article  Google Scholar 

  • Adams, C.W.M., Virag, S., Morgan, R.S., and Orton, C.C., 1968b, Dissociation of (3H) cholesterol and 125I-labelled plasma protein influx in normal and atheromatous rabbit aorta. J. Atheroscler. Res., 8:679.

    Article  Google Scholar 

  • Adams, C.W.M., 1969, Lipid histochemistry. Adv. Lipid Res., 7:1.

    Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1969, The relationship between diffuse intimal thickening, medial enzyme failure and intimal lipid deposition in various human arteries. J. Atherscler. Res., 10:327.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., Abdulla, Y.H., Mahler, R.F., and Root, M.A., 1969, Lipase, esterase and triglyceride in the ageing human aorta. J. Atheroscler. Res., 9:87.

    Article  Google Scholar 

  • Adams, C.W.M., Morgan, R.S., and Bayliss, O.B., 1970, The differential entry of (125I)-albumin into mildly and severely atheromatous rabbit aortas. Atherosclerosis, 11:119.

    Article  Google Scholar 

  • Adams, C.W.M., 1971, Lipids, lipoproteins and atherosclerotic lesions. Proc. Roy. Soc. Med., 64:902.

    Google Scholar 

  • Adams, C.W.M., 1972, “Research on Multiple Sclerosis.” Thomas, Springfield, Ill.

    Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1973, Acid mucosubstances underlying lipid deposits in ageing tendons and atherosclerotic arteries. Atherosclerosis, 18:191.

    Article  Google Scholar 

  • Adams, C.W.M., Morgan, R.S., and Bayliss, O.B., 1973, No regression of atheroma over one year in rabbits previously fed a cholesterol-enriched diet. Atherosclerosis, 18:429.

    Article  Google Scholar 

  • Adams, C.W.M., 1974, The histochemistry of smooth muscle. Adv. Exp. Med. Biol., 57, pp. 143, 274.

    Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1974, Lipid histochemistry, in “Techniques of Biochemical and Biophysical Morphology.” (D. Glick and R.M. Rosenbaum, eds.) Vol. 2, p. 99, Wiley, New York.

    Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., Baker, R.W.R., Abdulla, Y.H., and Hunter-Craig, C.J., 1974, Lipid deposits in aging human arteries, tendons and fascia. Atherosclerosis, 19:429.

    Article  Google Scholar 

  • Adams, C.W.M., Knox, J., and Morgan, R.S., 1975a, Exchange of plasma radioactive cholesterol with atheroma lipids in situ and implanted subcutaneously. Atherosclerosis, 22:229.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Turner, D.R., 1975b, Phagocytes, lipid-removal and atherosclerosis. J. Path., 116, 225.

    Article  Google Scholar 

  • Adams, C.W.M., Knox, J., and Morgan, R.S., 1975c, The resorption rate of atheroma lipids in situ and implanted subcutaneously. Atherosc1erosis, 22, 79.

    Article  Google Scholar 

  • Adams, C.W.M., 1975, Lipoprotein entry and fate in the arterial wall, in The Arterial Wall in Atherogenesis. (C. Cavallero, ed.) pp. 65–71, Piccin Medical Books, Padua.

    Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1975, Crystals in atherosclerotic lesions: real or artefact? Atherosclerosis, 22:629.

    Article  Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1976a, Succinic dehydrogenase and cytochrome oxidase in arterial venous and other smooth muscle. Atherosclerosis, 23:367.

    Article  Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1976b, Detection of macrophages in atherosclerotic lesions with cytochrome oxidase. Brit. J. Exp. Path., 57:30.

    Google Scholar 

  • Adams, C.W.M., Poston, R.N., and Morgan, R.S., 1976, Dietary restriction and regression of atherosclerosis. Virchows Arch. Abt. A, 371:53.

    Google Scholar 

  • Adams, C.W.M., 1976, Regression of atherosclerosis: cells and lipids, in Proceedings of the Vth International Congress of Histochemistry. Bucharest, p. 16.

    Google Scholar 

  • Adams, C.W.M., 1977, Dietary restriction and progress of atheroma. Advances in Experimental Medicine & Biology, 82:440.

    Google Scholar 

  • Adams, C.W.M., and Bayliss, O.B., 1977, Permeability of inner and outer layers of the rat and rabbit aortic wall: two new microscopic tests with trypan blue. Atherosclerosis, 26:419.

    Article  Google Scholar 

  • Adams, C.W.M., Bayliss, O.B., and Morgan, R.S., 1977, Permeability in atherosclerosis: fluorescence test in green light with trypan blue. Atherosclerosis, 27:353.

    Article  Google Scholar 

  • Adams, C.W.M., and Morgan, R.S., 1977, Regression of atheroma in the rabbit. Atherosclerosis, 28:399–404.

    Article  Google Scholar 

  • Adams, C.W.M., and Abdulla, Y.H., 1978, The action of human high density lipoprotein on cholesterol crystals, Part 1: Light-microscopic observations. Atherosclerosis, 31:465–471.

    Article  Google Scholar 

  • Adams, C.W.M., and Bayliss-High, O.B., 1979, Tissue reactions to oxidized derivatives of cholesterol. V International Symposium on Atherosclerosis, Houston, Texas, Abstracts, p. 1.

    Google Scholar 

  • Adams, C.W.M., and Bayliss-High, O.B., 1980, Mononuclear phagocytes in atherosclerosis. Atherosclerosis V (edited by A.M. Gotto, L.C. Smith and B. Allen), Springer, Berlin, pp. 130–133.

    Chapter  Google Scholar 

  • Ahmed, Z., and Reis, J.L., 1958, The activation and inhibition of 5′-nucleotidase. Biochem. J., 69:386.

    Google Scholar 

  • Aleo, J.J., and Cammarata, A., 1971, Experimental lathyrism: inhibition of β-alanine incorporation by β-aminopropionitrile. Experientia, 27:1161.

    Article  Google Scholar 

  • Altman, F.P., 1965, The retention and estimation of’ soluble’ dehydrogenases in unfixed tissue sections. Biochem. J., 96:53P.

    Google Scholar 

  • Altman, F.P., and Chayen, J., 1965, Retention of nitrogenous material in unfixed sections during incubation for histochemical demonstration of enzymes. Nature (Lond.), 207:1205.

    Article  ADS  Google Scholar 

  • Altschul, R., 1954, Endothelium: its development, morphology, function and pathology. MacMillan, New York.

    Google Scholar 

  • Anwar, R.A., 1977, Desmosine peptides: aminoacid sequences and the role of these sequences in crosslink formation. Adv. Exp. Med. Biol., 79:329.

    Google Scholar 

  • Armstrong, M., 1978, Connective Tissue in Regression. Atherosclerosis Reviews, 3:147–168. (Ed. by R. Paoletti and A.M. Gotto) Raven Press, New York.

    Google Scholar 

  • Armstrong, M.L., and Megan, M.B., 1972, Lipid depletion in atheromatous coronary arteries in rhesus monkeys after regression diets. Circulat. Res., 30:675.

    Google Scholar 

  • Armstrong, M.L., Warner, E.D., and Connor, W.E., 1970, Regression of coronary atheromatosis in rhesus monkeys. Circulat. Res., 27:59.

    Google Scholar 

  • Armstrong, M.L., Peterson, R.E., Hoak, J.C., Megan, M.B., Cheng, F.H., and Clarke, W.R., 1980, Arterial platelet accumulation in experimental hypercholestolemia. Atherosclerosis, 36:89–100.

    Article  Google Scholar 

  • Aschoff, L., 1924, Lectures on Pathology, p. 131, Hoeber, New York.

    Google Scholar 

  • Astrup, T., 1956, The biological significance of fibrinolysis. Lancet, ii:565.

    Article  Google Scholar 

  • Astrup, T., and Buluk, Karol, 1963, Thromboplastic and fibrinolytic activities in vessels of animals. Circulation Res., 13:253.

    Google Scholar 

  • Ayer, J.P., 1964, Elastic tissue, in International Review of Connective Tissue Research (D.A. Hall, ed.) Vol. 2, pp. 33–100, Academic Press, New York.

    Google Scholar 

  • Ayer, J.P., Hass, G.M., and Philpott, D.E., 1958, Aortic elastic tissue, Arch. Path., 65:519.

    Google Scholar 

  • Bachhuber, T.E., and Lalich, J.J., 1955, Effect of sweet pea meal on rat aorta. Arch. Path., 59:247.

    Google Scholar 

  • Bailey, A.J., 1969, The stabilization of the intermolecular crosslinks of collagen with ageing. Gerontologia, 15:65.

    Article  Google Scholar 

  • Bailey, A.J., and Peach, Catherine M., 1968, Isolation and structural identification of a labile intermolecular crosslink in collagen. Biochem. Biophys. Commun., 33:812.

    Article  Google Scholar 

  • Bailey, A.J., Peach, CM., and Fowler, L.J., 1970, Chemistry of the collagen cross-links. Isolation and characterization of two intermediate intermolecular cross-links in collagen. Biochem. J., 117:819.

    Google Scholar 

  • Bailey, J.M., 1973, Regulation of cell cholesterol content, in Atherogenesis: Initiating Factors, CIBA Foundation Symposium No. 12 (NS) p. 63–88.

    Google Scholar 

  • Balint, A., Veress, B., Nagy, Z., and Jellinek, H., 1972, Role of lipophages in the development of rat atheroma. Atherosclerosis, 15:7–15.

    Article  Google Scholar 

  • Baló, J., and Banga, I., 1950, Elastolytic activity of pancreatic extracts. Biochem. J., 46:384.

    Google Scholar 

  • Baló, J., 1963, Connective tissue changes in atherosclerosis, in International Review of Connective Tissue Research (D.A. Hall, ed.) Vol. 1, pp. 241–306, Academic Press, New York.

    Google Scholar 

  • Balogh, K., Jr., 1964, Dihydrolipoic dehydrogenase activity: a step in formation of acy1 coenzyme A, demonstrated histo-chemically. J. Histochem. Cytochem., 12:404.

    Article  Google Scholar 

  • Balogh, K., Jr., 1966, Histochemical demonstration of 3α-hydroxy-steroid dehydrogenase activity. J. Histochem. Cytochem., 14:77.

    Article  Google Scholar 

  • Banga, I., and Nowotny, A., 1951a, Comparative studies about adenosine triphosphatase activity of human muscles, aorta and arteria femoralis. Acta. Physiol. Hungary, 2:317.

    Google Scholar 

  • Banga, I., Nowotny, A., 1951b, Change of the ATPase activity and elastin content of the arterial wall in consequence of arteriosclerosis. Acta. Physiol. Hungary, 2:327.

    Google Scholar 

  • Banga, I., Mayláth-Pálagyi, J., and Jobbágy, A., 1966, Relationship between fluorescent substances and arteriosclerosis. Acta. Physiol. Hungary, 30:79.

    Google Scholar 

  • Barbey, S., and Borit, A., 1976, Acid esterase in human arteries. Histochemistry, 49:37.

    Article  Google Scholar 

  • Barbolini, G., Kolendo, A.B., and Pearse, A.G.E., 1971, Adenosine triphosphatases and related enzymes of the juxtaglomerular and arterial smooth muscle cells in rat kidney. Histochem. J., 3:435.

    Article  Google Scholar 

  • Barden, H., and Lazarus, S.S., 1963, Histochemical characteristics of adenosine triphosphate dephosphorylating enzymes in rabbit pancreas. J. Histochem. Cytochem., 11:578.

    Article  Google Scholar 

  • Barrnett, R.J., 1952, The distribution of esterolytic activity in the tissues of the albino rat as demonstrated with indoxyl acetate. Anat. Rec, 114:577.

    Article  Google Scholar 

  • Battaglia, S., and Matturri, L., 1962, Istochimica della sostanza amiloide umana. Riv. Istochim., 8:295.

    Google Scholar 

  • Bayliss, O.B., and Adams, C.W.M., 1973, Bromine-Sudan black: a general stain for lipids including free cholesterol. Histochem. J., 4:505.

    Article  Google Scholar 

  • Bayliss, O.B., and Adams, C.W.M., 1976, Resistance of aldehyde blockades to periodic acid. Histochem. J., 8:71.

    Article  Google Scholar 

  • Bayliss, O.B., and Adams, C.W.M., 1979, The pH dependence of borohydride as an aldehyde reductant. Histochemical Journal, 11:111–116.

    Article  Google Scholar 

  • Bayliss-High, O.B., and Adams, C.W.M., 1980, The role of macrophages and giant cells in advanced human atherosclerosis. Atheros clerosis, (in press).

    Google Scholar 

  • Becker, C.G., and Murphy, G.E., 1969, Demonstration of contractile protein in endothelium and cells of the heart valves, endocardium, intima, arteriosclerotic plaques and Aschoff bodies of rheumatic heart disease. Amer. J. Path., 55:1.

    Google Scholar 

  • Beisswenger, P.J., 1973, Specificity of the chemical alteration in the diabetic glomerular basement membrane. Diabetes, 22:744.

    Google Scholar 

  • Bell, C., 1969, Fine structural localization of acetylcholinesterase at a cholinergic nerve-arterial smooth muscle synapse. Circulat. Res., 24:61.

    Google Scholar 

  • Bell, F.P., and Schwartz, C.J., 1971, Exchangeability of cholesterol between swine serum lipoproteins and erythrocytes, in vitro. Biochem. Biophys. Acta., 231:553.

    Google Scholar 

  • Bell, F.P., Adamson, I.L., and Schwartz, C.J., 1974, Aortic endothelial permeability to albumin. Focal and regional patterns of uptake and transmural distribution of 131I-albumin in the young pig. Exp. Molec. Path., 20:57.

    Article  Google Scholar 

  • Bell, F.P., Day, A.J., Gent, M., and Schwartz, C.J., 1975, Differing patterns of cholesterol accumulation and 3H-cholesterol influx in areas of cholesterol-fed pig aorta identified by Evans blue dye. Exp. Molec. Path., 22:366.

    Article  Google Scholar 

  • Bella, A., Jr., and Danishefsky, I., 1968, The dermatan sulphate-protein linkage region. J. Biol. Chem., 243:2660.

    Google Scholar 

  • Benditt, E.P., Lagunoff, D., Eriksen, N., and Iseri, O.A., 1962, Amyloid: extraction and preliminary characterization of some proteins. Arch. Path., 74:323.

    Google Scholar 

  • Benditt, E.P., and Eriksen, N., 1971, Chemical classes of amyloid substance. Amer. J. Path., 65:231.

    Google Scholar 

  • Benditt, E.P., and Benditt, J.M., 1973, Evidence for a monoclonal origin of human atherosclerotic plaques. Proc. Nat. Acad. Sci., 70:1753.

    Article  ADS  Google Scholar 

  • Benditt, E.P., 1974, Evidence for the monoclonal origin of human atherosclerotic plaques and some implications. Circulation, 50:650.

    Google Scholar 

  • Bennett, H.S., 1963, Morphological aspects of extracellular polysaccharides. J. Histochem. Cytochem., 11:14.

    Article  Google Scholar 

  • Berenson, G.S., Dalferes, E.R., Jr., Robin, R,, and Strong, J.P., 1963, Mucopolysaccharides and atherosclerosis, in Evolution of the Atherosclerotic Plaque. (R.J. Jones, ed.) pp. 139–150, Chicago University Press.

    Google Scholar 

  • Berg, R., 1972, Histochemical studies on the carbohydrates in the wall of the coronary vessels of domestic pig. A comparison to man. Acta. Histochem., 43:333.

    Google Scholar 

  • Berry, C.L., Looker, T., and Germain, J., 1972, Nucleic acid and scleroprotein content of the developing human aorta. J. Path., 108:265.

    Article  Google Scholar 

  • Berry, C.L., Germain, J., and Lovell, P., 1974, Comparison of aortic lamellar unit structure in birds and mammals. Atherosclerosis, 19:47.

    Article  Google Scholar 

  • Berry, C.L., Greenwald, S., and Rivett, J., 1975, Static mechanical properties of the developing and mature rat aorta. Cardiovasc. Res., 9:669.

    Article  Google Scholar 

  • Bertelsen, S., and Christensen, H.E., 1959, Heparin as a constituent of experimental amyloid in mice. Acta. Path. Scand., 47:336.

    Article  Google Scholar 

  • Bertelsen, S., 1963, The role of ground substance, collagen and elastic fibers in the genesis of atherosclerosis, in Atherosclerosis and Its Origin. (M. Sandler and G.H. Bourne, eds.) pp. 119–165, Academic Press, New York.

    Google Scholar 

  • Bierman, E.L., Stein, O., and Stein, Y., 1974, Lipoprotein uptake and metabolism by rat aortic smooth muscle cells in tissue culture. Circulat. Res., 35:136.

    Google Scholar 

  • Bihari-Varga, M., Gergely, J., and Gerö, S., 1964, Further investigations on complex formation in vitro between aortic mucopolysaccharides and β-lipoproteins. J. Atheroscler. Res., 4:106.

    Article  Google Scholar 

  • Bihari-Varga, M., and Végh, M., 1967, Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins. Biochim. Biophys. Acta., 144:202.

    Google Scholar 

  • Björkerud, S., and Bondjers, G., 1971, Arterial repair and atherosclerosis after mechanical injury. Part 1. Permeability and light microscopic characteristics of endothelium in non-atherosclerotic and atherosclerotic lesions. Atherosclerosis, 13:355.

    Article  Google Scholar 

  • Björkerud, S., and Bondjers, G., 1972, Endothelial integrity and viability in the aorta of the normal rabbit and rat as evaluated with dye exclusion tests and interference contrast microscopy. Atherosclerosis, 15:285.

    Article  Google Scholar 

  • Bjökerud, S., Hansson, H.-A., and Bondjers, G., 1972, Subcellular valves and canaliculi in arterial endothelium and their equivalence to so-called stigmata. Virchows Arch. Abt. B. Cell Path., 11:19.

    Google Scholar 

  • Bladen, H.A., Nylen, M.U., and Glenner, G.G., 1966, The ultra-structure of human amyloid as revealed by the negative staining technique. J. Ultrastruct. Res., 14:449.

    Article  Google Scholar 

  • Blaga, F., 1963, The pathogenesis of arteriosclerosis, Arkh. Patol., 25:13. Transl. Abat. Wld. Med., 35:267, 1964.

    Google Scholar 

  • Blanton, F.S., Miller, W.H., Jr., and Warren, D., 1959, Experimental production of dissecting aneurysms of the aorta. Surgery, 45:81.

    Google Scholar 

  • Blomfield, Jeanette, and Farrar, J.F., 1969, The fluorescent properties of maturing arterial elastin. Cardiovasc. Res., 3:161.

    Article  Google Scholar 

  • Bloodworth, J.M.B., 1962, Diabetic retinopathy. Diabetes, 11:1.

    Google Scholar 

  • Blumenthal, H.T., Alex, M., and Goldenberg, S., 1961, A non-athero-matous proliferative vascular lesion of the retina in diabetes mellitus. Amer. J. Med., 31:382.

    Article  Google Scholar 

  • Blumenthal, H.T., Berns, A.W., Owens, CT., and Hirata, Y., 1962, The pathogenesis of diabetic glomerulosclerosis. I. The significance of various histopathological components of the disease. Diabetes, 11:296.

    Google Scholar 

  • Blumenthal, H.T., Berns, A.W., Goldenberg, S., and Lowenstein, P.W., 1966, Etiologic considerations in peripheral vascular diseases of the lower extremity with special reference to diabetes mellitus. Circulation, 33:98.

    Google Scholar 

  • Bo, W.J., and Smith, M.S., 1965, A histochemical and biochemical study of Phosphorylase and glycogen synthetase in smooth muscle. Anat. Ree, 153:295.

    Article  Google Scholar 

  • Boeré, H., Ruinen, L., and Scholten, J.H., 1965, Electron microscopic studies on the fibrillar component of human splenic amyloid. J. Lab. Clin. Med., 66:943.

    Google Scholar 

  • Bohr, D.F., Filo, R.S., and Guthe, K.F., 1962, Contractile protein in vascular smooth muscle. Physiol. Rev., 42: Suppl. No. 5, 98.

    Google Scholar 

  • Bondjers, G., and Björkerud, S., 1974, Cholesterol transfer between arterial smooth muscle tissue and serum lipoproteins in vitro. Artery, 1:3.

    Google Scholar 

  • Bondjers, G., and Björkerud, S., 1975, Transfer of cholesterol in vitro between normal arterial smooth muscle tissue and serum lipoproteins of normolipidemic rabbits. Atherosclerosis, 22:379.

    Article  Google Scholar 

  • Bondjers, G., Kral, J.G., Olsson, G., Schersten, T., 1980, HDL mediated cholesterol elimination from human arterial tissue. Influence of serum cholesterol levels. Exp. Molec. Path., 32: 23–31.

    Article  Google Scholar 

  • Borgers, M., Schaper, J., and Schaper, W., 1971, Localization of specific phosphatase activities in canine coronary blood vessels and heart muscle. J. Histochem. Cytochem., 19:526.

    Article  Google Scholar 

  • Born, G.V.R., 1966, Effects of adenosine diphosphate (ADP) and related substances on the adhesiveness of platelets in vitro and in vivo. Brit. J. Haematol., 12:37.

    Article  Google Scholar 

  • Bornstein, P., 1966, Cross linking of collagen chains. Fed. Proc, 25: pt. 1, pp. 1004–1009.

    Google Scholar 

  • Bornstein, P., 1974, The biosynthesis of collagen. Ann. Rev. Biochem., 43:567.

    Article  Google Scholar 

  • Bortz, W.M., 1968, Reversibility of atherosclerosis in cholesterol-fed rabbits. Circulat. Res., 22:136.

    Google Scholar 

  • Böttcher, C.J.F., and Klynstra, F.B., 1963, Acid mucopolysaccharides in human aortic tissues: the distribution at different stages of atherosclerosis. Lancet, ii:439.

    Article  Google Scholar 

  • Böttcher, C.J.F., 1964, Chemical constituents of human atherosclerotic lesions. Proc. Roy. Soc. Med., 57:792.

    Google Scholar 

  • Böttcher, C.J.F., and Boelsma-van Houte, E., 1964, Method for the histochemical identification of choline-containing phospholipids. J. Atheroscler. Res., 4:109.

    Article  Google Scholar 

  • Bradby, G.H.V., Walton, K.W., and Watts, R., 1979, The binding of total low density lipoproteins in human arterial intima affected and unaffected by atherosclerosis. Atherosclerosis, 32:403–422.

    Article  Google Scholar 

  • Bratzier, R.L., Chisolm, G.M., Colton, C.K., Smith, K.A., Zilversmit, D.B., and Lees, R.S., 1977a, The distribution of labeled albumin across the rabbit thoracic aorta in vivo. Circulat. R., 40:182.

    Google Scholar 

  • Bratzler, R.L., Chisolm, G.M., Colton, C.K., Smith, K.A., and Lees, R.S., 1977b, The distribution of labeled low-density lipoproteins across the rabbit thoracic aorta in vivo. Atherosclerosis, 28:289.

    Article  Google Scholar 

  • Braun-Falco, O., and Salfeld, K., 1959, Leucine aminopeptidase activity in mast cells. Nature (Lond.), 183:51.

    Article  ADS  Google Scholar 

  • Braunstein, H., 1960, Histochemical study of the adult aorta. Arch. Path., 69:617.

    Google Scholar 

  • Bretherton, K.N., Day, A.J., and Skinner, S.L., 1975, The effect of renal hypertension on the regional deposition of cholesterol and phospholipid in the aorta of normally and cholesterol-fed rabbits. Atherosclerosis, 22:517.

    Article  Google Scholar 

  • Bretherton, K.N., Day, A.J., and Skinner, S.L., 1976, Effect of hypertension on the entry of 125I-labeled low density lipoprotein into the aortic intima of normally fed rabbits. Atherosclerosis, 24:99.

    Article  Google Scholar 

  • Bretherton, K.N., Day, A.J., and Skinner, S.L., 1977, Hypertension-accelerated atherogenesis in cholesterol-fed rabbits. Atherosclerosis, 27:79–87.

    Article  Google Scholar 

  • Brody, I.A., and Engel, W.K., 1964, Effects of phenazine methosul-fate in histochemistry. J. Histochem. Cytochem., 12:928.

    Article  Google Scholar 

  • Brooks, C.J.W., Steel, G., Gilbert, J.D., Harland, W.A., 1971, Lipids of human atheroma: part 4: Characterisation of a new group of polar sterol esters from human atherosclerotic plaques. Atherosclerosis, 13:223–37.

    Article  Google Scholar 

  • Brown, M.S., and Goldstin, J.L., 1974, Suppression of 3-hydroxy-3-methyl glutaryl CoA reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol. J. Biol. Chem., 249:7306–14.

    Google Scholar 

  • Brundel, K.-H., and Sinapius, D., 1970, Lipids in aortic intima edema. Histological, histochemical and chromatographic investigations. Virchows Arch., Abt. A, 351–225.

    Google Scholar 

  • Buck, R.C., and Heagy, F.C., 1958, Uptake of radioactive sulphur by various tissues of normal and cholesterol-fed rabbits. Canad. J. Biochem. Physiol., 36:63.

    Article  Google Scholar 

  • Buck, R.C., 1963, Histogenesis and morphology of arterial tissue, in Atherosclerosis and Its Origin. (M. Sandler and G.H. Bourne, eds.) pp. 1–38, Academic Press, New York.

    Google Scholar 

  • Buck, R.C., 1977, Organ cultures of rat aorta: a scanning and transmission electron microscope study. Exp. Molec. Path., 26:260–276.

    Article  Google Scholar 

  • Buddecke, E., 1962, Chemical changes in the ground-substance of the vessel wall in arteriosclerosis. J. Atheroscler. Res., 2:32.

    Article  Google Scholar 

  • Burke, J.M., and Ross, R., 1977, Collagen synthesis by monkey arterial smooth muscle cells during proliferation and quiescence in culture. Exp. Cell Res., 107, 387.

    Article  Google Scholar 

  • Burkholder, P.M., 1965, Immunohistopathologic study of localized plasma proteins and fixation of guinea pig complement in renal lesions of diabetic glomerulosclerosis. Diabetes, 14:755.

    Google Scholar 

  • Burns, J., and Whitehead, R., 1966, Staining of Paneth cells with thioflavine T. Nature (Lond.), 211:769.

    Article  ADS  Google Scholar 

  • Burnstock, G., Gannon, B., and Iwayama, T., 1970, Sympathetic innervation of vascular smooth muscle in normal and hypertensive animals. Circulat. Res., 27: Suppl. 2, 5.

    Google Scholar 

  • Burnstock, G., 1977, The purinergic nerve hypothesis CIBA Foundation Symposium. 48 (NS) 295–307.

    Google Scholar 

  • Buxtorf, J.C., Beaumont, V., Jacotot, B., and Beaumont, J.L., 1974, Regression de xanthomes et medicamente hypolipidemiants. Atherosc1erosis, 17:1.

    Article  Google Scholar 

  • Cairns, A., and Constantinides, P., 1954, Mast cells in human atherosclerosis. Science, 120:31.

    Article  ADS  Google Scholar 

  • Camejo, G., Acquatella, H., and Lalaguna, F., 1980, The interaction of low density lipoproteins with arterial proteoglycans. An additional risk factor? Atherosclerosis, 36:55–65.

    Article  Google Scholar 

  • Campbell, D.J., Day, A.J., Skinner, S.L., and Tume, R.K., 1973, The effect of hypertension on the accumulation of lipids and the uptake of (3H)-cholesterol by the aorta of normal-fed and cholesterol-fed rabbits. Atherosclerosis, 18:301.

    Article  Google Scholar 

  • Caplan, B.A., and Schwartz, C.J., 1973, Increased endothelial cell turnover in areas of in vivo Evans blue uptake in the pig aorta. Atherosclerosis, 17:401.

    Article  Google Scholar 

  • Carew, T.E., Hayes, B., Koachinsky, T., and Steinberg, D., 1976, A mechanism by which high-density lipoprotein may slow the atherogenic process. Lancet, i:1315.

    Article  Google Scholar 

  • Carnes, W.H., Coulson, W.F., and Albino, Amelia M., 1965, Intimal lesions in muscular arteries of young copper-deficient swine. Annal. N.Y. Acad. Sci., 127:800.

    Article  ADS  Google Scholar 

  • Cathcart, E.S., and Cohen, A.S., 1966, The relation between isolated human amyloid fibrils and human γ-globulin and its subunits. J. Immunol., 96:239.

    Google Scholar 

  • Cavallero, C., Di Tondo, U., Mingazzini, P.L., Pesando, P.C., and Spagnoli, L.G., 1973, Cell proliferation in the atherosclerotic lesions of cholesterol-fed rabbits. Atherosclerosis, 17:49.

    Article  Google Scholar 

  • Chen, M., McCarry, J., Chan, M.M., Riggins, R.S., and Bucker, R.B., 1973, Chick aorta pyrophosphatase. Proc. Soc. Exp. Biol. Med., 143:44.

    Google Scholar 

  • Clarke, J.A., 1964, An X-ray microscopic study of the vasa vasorum of normal human coronary arteries. J. Anat. (Lond.), 98:539.

    Google Scholar 

  • Clarke, J.A., 1965a, An X-ray microscopic study of the postnatal development of the vasa vasorum in the human aorta. J. Anat. (Lond.), 99:877.

    Google Scholar 

  • Clarke, J.A., 1965b, The vasa vasorum of normal human lower limb arteries. Acta. Anat., 61:481.

    Article  Google Scholar 

  • Clarke, J.A., 1966, An X-ray microscopic study of the postnatal development of the vasa vasorum of normal human coronary arteries. Acta. Anat., 64:506.

    Article  Google Scholar 

  • Cleland, J.B., 1951, Splitting the aorta and dissecting aneurysm. Med. J. Australia, ii:399.

    Google Scholar 

  • Cogan, D.G., and Kuwahara, T., 1959, Arcus senilis: its pathology and histochemistry. Arch. Ophthal., 61:553.

    Article  Google Scholar 

  • Cohen, A.S., and Calkins, E., 1959, Electron microscopic observations on a fibrous component in amyloid of diverse origin. Nature (Lond.), 183:1202.

    Article  ADS  Google Scholar 

  • Cohen, A.S., 1965, The constitution and genesis of amyloid, in International Review of Experimental Pathology. (G.W. Richter and M.A. Epstein, eds.) Vol. 4, pp. 159–243, Academic Press, New York.

    Google Scholar 

  • Cohen, A.S., 1966, Preliminary chemical analysis of partially purified amyloid fibrils. Lab. Invest., 15:66.

    Google Scholar 

  • Cohen, M.P., and Foglia, V.G., 1969, Sulfate35 uptake and incorporation into aortic mucopolysaccharides in experimental diabetes. Proc. Soc. Exp. Biol. (N.Y.), 132:376.

    Google Scholar 

  • Cohen, M.P., and Foglia, V.G., 1970, Aortic mucopolysaccharides in experimental diabetes. Diabetes, 19:639.

    Google Scholar 

  • Coltoff-Schiller, B., Goldfisher, S., Wolinsky, H., and Factor, S.M., 1976, Lipid accumulation in human aortic smooth muscle cell lysosomes. Amer. J. Path., 83:39.

    Google Scholar 

  • Constantinides, P., 1953, Mast cells and susceptibility to experimental atherosclerosis. Science, 117:505.

    Article  ADS  Google Scholar 

  • Constantinides, P., 1965, Experimental Atherosclerosis, p. 42, Elsevier, Amsterdam.

    Google Scholar 

  • Constantinides, P., 1966, Plaque fissures in human coronary thrombosis. J. Atheroscler. Res., 6:1.

    Article  Google Scholar 

  • Constantinides, P., 1973, 4th Congress European Society of Pathology, Budapest (1973).

    Google Scholar 

  • Constantinides, P., and Wiggers, K.D., 1974, Electronmicroscopic autoradiographic study of cholesterol passage across arterial and capillary endothelium. Virchows Arch., 362:291.

    Google Scholar 

  • Constantinides, P., 1978, Appraisal of the tumorigenic theory of atherosclerosis. Arch. Pathol, (in press).

    Google Scholar 

  • Cooper, J.H., 1969, An evaluation of current methods for the diagnostic histochemistry of amyloid. J. Clin. Path., 22:410.

    Article  Google Scholar 

  • Cooper, J.H., 1971, The Casella reaction and the permanganate-induced basophilia of human elastica. J. Histochem. Cytochem., 19:564.

    Article  Google Scholar 

  • Cooper, J.H., 1974, Selective amyloid staining as a function of amyloid composition and structure. Lab. Invest., 31:232.

    Google Scholar 

  • Cotran, R.S., 1965, On the presence of an amorphous layer lining vascular endothelium under abnormal conditons. Lab. Invest., 14:1826.

    Google Scholar 

  • Crane, W.A.J., and Dutta, L.P., 1964, The influence of age on the uptake of 35S-sulphate and 3H-thymidine by the mesenteric arteries of rats with regenerating adrenal glands. J. Path. Bact., 88:291.

    Article  Google Scholar 

  • Crane, W.A.J., and Ingle, D.J., 1964, Tritiated thymidine uptake in rat hypertension. Arch. Path., 78:209.

    Google Scholar 

  • Crawford, T., and Levene, C.I., 1953, Medial thinning in atheroma. J. Path. Bact., 66:19.

    Article  Google Scholar 

  • Crawford, T., 1961, Morphological aspects in the pathogenesis of atherosclerosis. J. Atheroscler. Res., 1:3.

    Article  Google Scholar 

  • Curran, R.C., 1957, The elaboration of mucopolysaccharides by vascular endothelium. J. Path. Bact., 74:347.

    Article  Google Scholar 

  • Curran, R.C., and Crane, W.A.J., 1962, Mucopolysaccharides in the atheromatous aorta. J. Path. Bact., 84:405.

    Article  Google Scholar 

  • Curran, R.C., 1964, Mucopolysaccharides and collagen formation in atherosclerosis, in Biological Aspects of Occlusive Vascular Disease (D.G. Chalmers and G.A. Gresham, eds.) pp. 76–83, Cambridge University Press.

    Google Scholar 

  • Currerri, P.W., Kothari, H.V., Bonner, M.J., and Miller, B.F., 1969, Increased activity of lysosomal enzymes in experimental atherosclerosis, and the effect of cortisone. Proc. Soc. Exp. Biol. Med., 130:1253.

    Google Scholar 

  • Dalferes, E.R., Jr. Radhakrishnamurthy, B., and Berenson, G.S., 1967, Acid mucopolysaccharides of amyloid tissue. Arch. Bio-Chem. Biophys., 118:284.

    Article  Google Scholar 

  • Daneshbod, K., and Liao, K.T., 1973, Hyaline degeneration of splenic follicular arteries in infectious mononucleosis: histochemical and electron microscopic studies. Amer. J. Clin. Path., 59:473.

    Google Scholar 

  • Daoud, A.S., Jarmolych, J., Augustyn, J.M., Fritz, K.E., Singh, J.K., and Lee, K.T., 1976, Regression of advanced atherosclerosis in swine. Arch. Path., 100:372.

    Google Scholar 

  • Darzynkiewicz, Z., and Barnard, E.A., 1967, Specific proteases of the rat mast cell. Nature (Lond.), 213:1198.

    Article  ADS  Google Scholar 

  • Davis, J.N., Adams, C.W.M., and Bayliss, O.B., 1963, Gradient in cholesterol concentration across human aortic wall. Lancet, ii:1254.

    Article  Google Scholar 

  • Davies, P.F., and Bowyer, D.E., 1975, Scanning electron microscopy: Endothelial integrity after fixation at physiological pressure. Atherosc1erosis, 21;463.

    Article  Google Scholar 

  • Dayton, S., and Hashimoto, S., 1970, Recent advances in molecular pathology: a review. Cholesterol flux and metabolism in arterial tissue and atheromata. Exp. Molec. Path., 13:253.

    Article  Google Scholar 

  • De Faria, J.L., 1968, Role of wall factors in the pathogenesis of coronary atherosclerosis. An approach based upon quantitative histological changes in the non-atheromatous intimal thickening and in the tunica media. J. Atheroscler. Res., 8:291.

    Article  ADS  Google Scholar 

  • De Navasquez, S.J., 1964, Absence of atherosclerosis in necropsies on the victims of Belsen concentration camp. Personal communication.

    Google Scholar 

  • DePalma, R.G., Koletsky, S., Bellon, E.M., and Insull, W., 1977, Failure of regression of atherosclerosis in dogs with moderate cholesterolemia. Atherosclerosis, 27:297–310.

    Article  Google Scholar 

  • Devine, C.E., and Simpson, F.O., 1968, Localization of tritiated norepinephrine in vascular sympathetic axons of the rat intestine and mesentery by electronmicroscope autoradiography. J. Cell Biol., 38:184.

    Article  Google Scholar 

  • Diezel, P.B., and Pfleiderer, A., Jr., 1959, Histochemische und polarisationsoptiche Untersuchungen am Amyloid. Virchows Arch. Path. Anat., 332:552.

    Article  Google Scholar 

  • Dingemans, K.P., and Wagenvoort, C.A., 1978, Pulmonary arteries and veins in experimental hypoxia. Amer. J. Pathol., 93:353–368.

    Google Scholar 

  • Dixon, K.C., 1961, Deposition of globular lipid in arterial cells in relation to anoxia. Amer. J. Path., 39:65.

    Google Scholar 

  • Dobbing, J., 1961, The blood-brain barrier. Physiol. Rev., 41:130.

    Google Scholar 

  • Doležel, S., 1966, Histochemical identification of monoamine in the arterial wall. Experientia, 22:307.

    Article  Google Scholar 

  • Duff, G.L., and McMillan, G.C., 1951, Pathology of atherosclerosis. Amer. J. Med., 11:92.

    Article  Google Scholar 

  • Duguid, J.B., 1946, Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J. Path. Bact., 58:207.

    Article  Google Scholar 

  • Duguid, J.B., 1952, The arterial lining. Lancet, ii:207.

    Article  Google Scholar 

  • Duncan, L.E., and Buck, K., 1959, Passage of labeled cholesterol into the aortic wall of the normal dog. Circulat. Res., 7:765.

    Google Scholar 

  • Duncan, L.E., Jr., Cornfield, J., and Buck, K., 1959, Circulation of labeled albumin through the aortic wall of the dog. Circulat. Res., 7:390.

    Google Scholar 

  • Duncan, L.E., Jr., and Buck, K., 1960, Passage of labeled albumin into canine aortic wall in vivo and in vitro Amer. J. Physiol., 200:622.

    Google Scholar 

  • Duncan, L.E., Jr., and Buck, K., 1962, Comparison of rates at which albumin enters walls of small and large aortas. Amer. J. Physiol., 203:1167.

    Google Scholar 

  • Duncan, L.E., Jr., Cornfield, J., and Buck, K., 1962, The effect of blood pressure on the passage of labeled albumin into canine aortic wall. J. Clin. Invest., 41:1537.

    Article  Google Scholar 

  • Duncan, L.E., Jr., Buck, K., and Lynch, A., 1965, The effect of pressure and stretching on the passage of labeled albumin into canine aortic wall. J. Atheroscler. Res., 5:69.

    Article  Google Scholar 

  • Dunstone, J.R., 1967, Acid glycosaminoglycans of pig aorta. Experientia, 23:344.

    Article  Google Scholar 

  • Dustin, P., Jr., 1962, Arteriolar hyalinosis. Internat. Rev. Exp. Path., 1:73.

    Google Scholar 

  • Eades, CH., Jr., Phillips, G.E., and Solberg, V.B., 1962, Coronary atherosclerosis in renal hypertensive rats. Proc. Soc. Exp. Biol. (N.Y.), 110:65.

    Google Scholar 

  • Eanes, E.D., and Glenner, G.G., 1968, X-ray diffraction studies on amyloid filaments. J. Hystochem. Cytochem., 16:673.

    Article  Google Scholar 

  • Eggen, D.A., Strong, J.P., Newman, W.P., III., Catsulis, C., Malcolm, G.T., and Kokatnur, M.G., 1974, Regression of diet-induced fatty streaks in Rhesus monkeys. Lab. Invest., 31:294.

    Google Scholar 

  • Eisenstein, R., Scott, R.A., and Lesak, A.E., 1971, Altered lipid and calcium binding by calcified aortic elastin. Arch. Path., 92:301.

    Google Scholar 

  • El-Maghraby, M.A.H., and Gardner, D.L., 1968, A comparative study in young male animals of 10 species of the distribution of alkaline phosphatase activity in small arteries. Histochemie, 16:227.

    Article  Google Scholar 

  • El-Maghraby, M.A.H., and Gardner, D.L., 1972, Development of connective tissue components of small arteries in the chick embryo. J. Path., 108:281.

    Article  Google Scholar 

  • Elleder, M., and Lojda, Z., 1968, Remarks on the OTAN reaction. Histochemie, 14:47.

    Article  Google Scholar 

  • Elleder, M., and Lojda, Z., 1971, Studies in lipid histochemistry. VI, Problems of extraction with acetone in lipid histochemistry. Histochemie, 28:68.

    Article  Google Scholar 

  • Elleder, M., and Lojda, Z., 1973, New, rapid, simple and selective method for the demonstration of phospholipids. Histochemie, 36:148.

    Article  Google Scholar 

  • Ende, N., Katayama, Y., and Auditore, J.V., 1964, Multiple proteolytic enzymes in the human mast cells. Nature (Lond.), 201:1197.

    Article  ADS  Google Scholar 

  • Enerbäck, L., 1963, Serotonin in human mast cells. Nature (Lond.), 197:610.

    Article  ADS  Google Scholar 

  • Engel, U.R., 1971, Glycosaminoglycans in the aorta of six normal species. Atherosclerosis, 13:45.

    Article  Google Scholar 

  • Everett, A.L., Cordon, T.C., Kravitz, E., and Naghski, J., 1959, In situ histological evaluation of elastase activity. Stain Tech., 34:325.

    Google Scholar 

  • Fagerberg, S.-E., 1957, Studies on pathogenesis of diabetic neuropathy. IV. Angiopathica diabetica vasae nervorum. Acta. Med. Scand., 159:59.

    Article  Google Scholar 

  • Falconer, G.F., and Adams, C.W.M., 1965, The relationship between nutritional state and severity of atherosclerosis. Guy’s Hosp. Rep., 114:130.

    Google Scholar 

  • Farber, E., and Bueding, E., 1956, Histochemical localization of specific oxidative enzymes. V. The dissociation of succinic dehydrogenase from carriers by lipase and the specific localization of the dehydrogenase with phenazine methosulfate and tetrazolium salts. J. Histochem. Cytochem., 4:357.

    Article  Google Scholar 

  • Farber, E., 1962, Control studies on the histochemical localization of specific DPN-linked dehydrogenases. J. Histochem. Cytochem., 10:657.

    Google Scholar 

  • Farquhar, Susan, and Dunstone, J.R., 1968, Acid glycosaminoglycan composition of aortic tissue from chickens fed on commercial and cholesterol-supplemented diets. Experientia, 24:426.

    Article  Google Scholar 

  • Fawns, H.T., and Landells, J.W., 1954, Histochemical studies of rheumatic conditions. II. The nodule of rheumatoid arthritis. Ann. Rheum. Dis., 13:28.

    Article  Google Scholar 

  • Feldman, J.D., Mardiney, M.R., Unanue, E.R., and Cutting, H., 1966, The vascular pathology of thrombotic thrombocytopenic purpura. An immunohistochemical and ultrastructural study. Lab. Invest., 15:927.

    Google Scholar 

  • Feldman, S.A., and Glagov, S., 1971, Transmedial collagen and elastin gradients in human aortas: reversal with age. Atherosclerosis, 13:385.

    Article  Google Scholar 

  • Felt, V., 1960, The role of the blood vessel wall in the pathogenesis of atherosclerosis. Review Czechoslav. Med., 6:126.

    Google Scholar 

  • Fernex, M., and Sternby, N.H., 1964, Mast cells and coronary heart disease. Relationship between number of mast cells in the myocardium, severity of coronary atherosclerosis and myocardial infarction in an autopsy series of 672 cases. Acta. Path. Scand., 62:525.

    Google Scholar 

  • Fessler, J.H., 1960, A structural function of mucopolysaccharide in connective tissue. Biochem. J., 76:124.

    Google Scholar 

  • Feulgen, R., and Voit, K., 1924, Ueber einen weitverbreiteten festen Aldehyd. Seine Entstehung aus einer Vorstufe, sein mikrochemischer Nachweis und die Wege zu seiner praparativen Darstellung. Pflug. Arch. Gen. Physiol., 206:389.

    Article  Google Scholar 

  • Finlayson, R., and Woods, S.J., 1975, Lipid in the Achille’s tendon: a comparative study. Atherosclerosis (in press).

    Google Scholar 

  • Firstbrook, J.B., 1950, The effect of changes in body weight on atherosclerosis in rabbits. Science, 111:31.

    Article  ADS  Google Scholar 

  • Fisher, E.R., Rosenthal, T.B., and Lansing, A.I., 1960, Elastolytic effect of pepsin. J. Histochem. Cytochem., 8:102.

    Article  Google Scholar 

  • Fisher, E.R., and Danowski, T.S., 1968, Histologic, histochemical and electron microscopic features of the shin spots of diabetes mellitus. Amer. J. Clin. Path., 50:547.

    Google Scholar 

  • Fisher-Dzoga, K., Jones, R.M., Vesselinovitch, D., and Wissler, R.W., 1973, Ultrastructural and immunohistochemical studies of primary cultures of aortic medial cells. Exp. Molec. Path., 18:162.

    Article  Google Scholar 

  • Fishkin, A.F., and Spangler, P.M., 1969, Glycoproteins in foetal and adult cattle aortas. Nature (Lond.), 218:577.

    Article  ADS  Google Scholar 

  • Fitzpatrick, M., and Hospelhorn, V.D., 1965, Changes in aminoacid composition of aortic elastin with ageing and atherosclerosis. Amer. Heart J., 69:211.

    Article  Google Scholar 

  • Florey, H.W., Poole, J.CF., and Meek, G.A., 1959, Endothelial cells and “cement” lines. J. Path. Bact., 77:625.

    Article  Google Scholar 

  • Florey, H.W., and Sheppard, B.L., 1970, The permeability of arterial endothelium to horseradish peroxidase. Proc. Roy. Soc. B., 174:435.

    Article  ADS  Google Scholar 

  • Forman, D.T., Choi, S.S., and Taylor, C.B., 1968, Sulfate content of aortic wall in experimentally induced atherosclerosis. Arch. Path., 85:80.

    Google Scholar 

  • Fouquet, J.P., 1961, Dé p̂ot expérimental de cholestérol dans l′aorte du lapin, modifications histoenzymologiques corrélatives. Ann. Histochim., 6:153.

    Google Scholar 

  • Franzblau, C, Sinex, M., Faris, B., and Lampidis, R., 1965, Identification of a new cross linking amino acid in elastin. Biochem. Biophys. Res. Commun., 21:575.

    Article  Google Scholar 

  • Franzblau, C, Faris, B., and Papaioannou, R., 1969, Lysinonor-leucine: a new aminoacid from hydrolysates of elastin. Biochemistry, 8:2833.

    Article  Google Scholar 

  • Franzblau, C, Foster, J.A., and Faris, B., 1977, Role of cross-linking in fiber formation. Adv. Exp. Med. Biol., 79:313.

    Google Scholar 

  • French, J.E., and Benditt, E.P., 1953, Histochemistry of connective tissue: effects of proteins on selective staining of mucopolysaccharides by basic dyes. J. Histochem. Cytochem., 1:321.

    Article  Google Scholar 

  • French, J.E., 1963, Endothelial structure and function, in Evolution of the Atherosclerotic Plaque (R.J. Jones, ed.) pp. 15–28, University of Chicago Press.

    Google Scholar 

  • French, J.E., 1964, The structure of the tunica intima of arteries, in Biological Aspects of Occlusive Vascular Disease (D.G. Chalmers and G.A. Gresham, eds.) pp. 24–30, Cambridge University Press.

    Google Scholar 

  • French, J.E., Jennings, M.A., and Florey, H.W., 1965, Morphological studies on atherosclerosis in swine. Ann. N.Y. Acad. Sci., 127:780.

    Article  ADS  Google Scholar 

  • French, J.E., 1966, Atherosclerosis in relation to the structure and function of the arterial intima, with special reference to the endothelium. Internat. Rev. Exp. Path., 5:253.

    Google Scholar 

  • Friedman, M., and Byers, S.O., 1962, Excess lipid leakage: a property of very young vascular endothelium. Brit. J. Exp. Path., 43:363.

    Google Scholar 

  • Friedman, M., and Byers, S.O., 1963, Endothelial permeability in atherosclerosis. Arch. Path., 76:99–105.

    Google Scholar 

  • Fry, D.L., 1973, Responses of the arterial wall to certain physical factors, in Atherogenesis: Initiating Factors. CIBA Foundation Symposium, No. 12, p. 93.

    Google Scholar 

  • Fu, S.-T., Ho, K.-J., and Taylor, C.B., 1972, Cholesterol and acid mucopolysaccharides in hypercholesterolaemic rabbits. Arch. Path., 94:466.

    Google Scholar 

  • Fuchs, U., and Scharnweber, W., 1968, Elektronenmikroskopische Untersuchungen and Sketmuskelcapillaren des Menschen bei Arteriosklerose und Diabetes mellitus. Virchows Arch., 343:276.

    Article  Google Scholar 

  • Fullmer, H.M., and Lillie, R.D., 1956, Some aspects of the mechanism of orcein staining. J. Histochem. Cytochem., 4:64.

    Article  Google Scholar 

  • Fullmer, H.M., and Lillie, R.D., 1957, The staining of collagen with elastic tissue stains. J. Histochem. Cytochem., 5:11.

    Article  Google Scholar 

  • Fullmer, H.M., 1965, The histochemistry of the connective tissues, in International Review of Connective Tissue Research (D.A. Hall, ed.) Vol. 3, pp. 1–76, Academic Press, New York.

    Google Scholar 

  • Gahan, P.B., and Maggi, V., 1962, Demonstration of bound lipids in human arteries and their possible metabolic significance. Biochem. J., 85:30P.

    Google Scholar 

  • Gahan, P.B., and Kalina, M., 1965, The validity of using neotetra-zolium for studying labile, NADP-linked dehydrogenases in histological sections: a quantitative study. Biochem. J., 96:11P.

    Google Scholar 

  • Gammal, E.B., and Monture, M.C., 1979, Uptake of Evans blue-bound albumin in the aorta of oestrogen-treated rats. Brit. J. Exp. Path., 60:58–64.

    Google Scholar 

  • Garbarsch, C, Matthiessen, M.E., Helin, P., and Lorenzen, I., 1969, Arteriosclerosis and hypoxia, Part 1. (Gross and microscope changes in rabbit aorta induced by systemic hypoxia. Histochemical studies.) J. Atheroscler. Res., 9:283.

    Article  Google Scholar 

  • Garbarsch, C., 1973, Distribution of urea-stable and urea-labile lactic dehydrogenase activity in rabbit aorta following a single mechanical dilatation injury. Acta. Histochem., 46:288.

    Google Scholar 

  • Gardner, D.L., and Laing, C.P., 1965, Measurement of enzyme activity of isolated small arteries in early rat hypertension. J. Path. Bact., 90:399.

    Article  Google Scholar 

  • Gardner, D.L., and Cuthbert, J., 1967, A histochemical study of enzyme activity in normal and hypertensive rat visceral arterioles. Brit. J. Exp. Path., 48:427.

    Google Scholar 

  • Gardner, D.L., and Wyke, A.W., 1970, Influence of age and method of caging on small artery enzyme activities. Brit. J. Exp. Path., 51:518.

    Google Scholar 

  • Gardner, M.B., and Blankenhorn, D.H., 1968, Aortic medial calcification. Arch. Path., 85:397.

    Google Scholar 

  • Garfield, R.E., Chacko, S., and Blose, S., 1975, Phagocytosis by muscle cells. Lab. Invest., 33:418.

    Google Scholar 

  • Gaton, E., Bubis, J.J., and Wolman, M., 1975, Acid esterase in the aorta of the hyperlipidemic rat: A histochemical study. Path. Europ., 10:129.

    Google Scholar 

  • Gaton, E., Ben-Ishay, D., and Wolman, M., 1976, Experimentally produced hypertension and aortic acid esterase. Arch. Path., 100:527.

    Google Scholar 

  • Gaton, E., and Wolman, M., 1977, The role of smooth muscle cells and haematogenous macrophages in atheroma. J. Pathol., 123:123.

    Article  Google Scholar 

  • Geer, J.C., McGill, H.C., Jr., Robertson, W.B., and Strong, J.P., 1968, Histologic characteristics of coronary artery fatty streaks. Lab. Invest., 18:105.

    Google Scholar 

  • Geer, J.C., and Haust, M.D., 1972, Smooth muscle cells in atherosclerosis, Monographs on Atherosclerosis. Vol. 2, Kager, Basel.

    Google Scholar 

  • Geiringer, E., 1951, Intimal vascularisation and atherosclerosis. J. Path. Bact., 63:201.

    Article  Google Scholar 

  • Gerö, S., Gergely, J., Dévényi, T., Jakab, L., Székely, J., and Virág, S., 1961, Role of mucoid substances of the aorta in deposition of lipids. Nature (Lond.), 187:152.

    Article  ADS  Google Scholar 

  • Gerö, S., Gergely, J., Dévényi, T., Jakab, L., Székely, J., and Virág, S., 1961, Role of intimal mucoid substances in the pathogenesis of atherosclerosis. I. Complex formation in vitro between mucopolysaccharides from atherosclerotic aortic intimas and plasma β-lipoprotein and fibrinogen. J. Atheroscler. Res., 1:67.

    Article  Google Scholar 

  • Gerö, S., Gergely, J., Farkas, K., Dévényi, T., Kosár, L., Jakab, L., Székely, J., and Virág, S., 1962, Changes of tissue and blood mucopolysaccharides in cholesterol-fed animals. J. Atheroscler. Res., 2:276.

    Article  Google Scholar 

  • Gerrity, R.G., Adams, E.P., and Cliff, W.J., 1975, The aortic tunica media of the developing rat. II. Incorporation by medial cells of 3H-proline into collagen and elastin: autoradiographic and chemical studies. Lab. Invest., 32:601.

    Google Scholar 

  • Gerrity, R.G., and Naito, H.K., 1980, The movement of foam cells through arterial endothelium overlying atherosclerotic lesion. Atherogenesis 4. Abstracts 2nd International Atherosclerosis Conference, Vienna, p. 57.

    Google Scholar 

  • Geyer, G., 1969, Zur histochemie des Elastins Untersuchungen Nachweis von Desmosinen. Acta. Histochem., 34:257.

    Google Scholar 

  • Ghidoni, J.J., and O’Neal, R.M., 1967, A reveiw: Ultrastructure of human atheroma. Exp. Molec. Path., 7:378.

    Article  Google Scholar 

  • Giertsen, J.C., 1966, Atherosclerosis in an autopsy series. 10. Relation of nutritional state to atherosclerosis. Acta. Path. Scand., 67:305.

    Google Scholar 

  • Gillman, T., Penn, J., Bronks, D., and Roux, M., 1955, Abnormal elastic fibers. Arch. Path., 59:733.

    Google Scholar 

  • Gillman, T., 1959, Reduplication, remodeling, regeneration, repair, and degeneration of arterial elastic membranes. Arch. Path., 67:624.

    Google Scholar 

  • Gillman, T., 1964, A plea for arterial biology as a basis for understanding arterial disease, in Biological Aspects of Occlusive Vascular Disease (D.G. Chalmers and G.A. Gresham, eds.) pp. 2–23, Cambridge University Press.

    Google Scholar 

  • Gillman, T., 1968, On the possible roles of arterial growth, remodelling, repair, and involution in the genesis of arterial degeneration. Ann. N.Y. Acad. Sci., 149:731.

    Article  ADS  Google Scholar 

  • Gitlin, D., Craig, J.M., and Janeway, C.W., 1957, Studies on the nature of fibrinoid in the collagen diseases. Amer. J. Path., 33:55.

    Google Scholar 

  • Glagov, S., and Wolinsky, H., 1963, Aortic wall as a ‘two-phase’ material. Nature (Lond.), 199:606.

    Article  ADS  Google Scholar 

  • Glenner, G.G., 1957, The histochemical demonstration of indole derivatives by the rosindole reaction of E. Fischer. J. Histochem. Cytochem., 5:297.

    Article  Google Scholar 

  • Glenner, G.G., and Lillie, R.D., 1959, Observations on the diazo-tization-coupling reaction for the histochemical demonstration of tyrosine: metal chelation and formazin variants. J. Histochem. Cytochem., 7:416.

    Article  Google Scholar 

  • Glenner, G.G., and Cohen, L.A., 1960, Histochemical demonstration of a species-specific trypsin-like enzyme in mast cells. Nature (Lond.), 185:846.

    Article  ADS  Google Scholar 

  • Glenner, G.G., 1965, Enzyme histochemistry, in Neurohistochemistry (C.W.M. Adams, ed.) pp. 109–160, Elseviers, Amsterdam.

    Google Scholar 

  • Glenner, G.G., Ein, D., Eanes, E.D., Bladen, H.A., Terry, W., and Page, D.L., 1971, Creation of “amyloid” fibrils from Bence Jones proteins in vitro. Science, 174:712.

    Article  ADS  Google Scholar 

  • Glenner, G.G., Terry, W., Harada, M., Isersky, C, and Page D., 1971. Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses. Science, 172:1150–1.

    Article  ADS  Google Scholar 

  • Glenner, G.G., Eanes, E.D., and Page, D.L., 1972a, The relation of the properties of Congo Red-stained amyloid fibrils to the β-conformation. J. Histochem. Cytochem., 20:821.

    Article  Google Scholar 

  • Glenner, G.G., Ein, D., and Terry, W.D., 1972b, The immunoglobulin origin of amyloid. Amer. J. Med., 52:141.

    Article  Google Scholar 

  • Gofman, J.W., and Young, W., 1963, The filtration concept of atherosclerosis and serum lipids in the diagnosis of atherosclerosis, in Atherosclerosis and Its Origin. (M. Sandler and G.H. Bourne, eds.) pp. 197–229, Academic Press, New York.

    Google Scholar 

  • Goldenberg, S., Alex, M., Joshi, R.A., and Blumenthal, H.J., 1959, Non-atheromatous peripheral vascular disease of the lower extremity in diabetes-mellitus. Diabetes, 8:261.

    Google Scholar 

  • Goldfischer, S., Schiller, B., and Wolinsky, H., 1975, Lipid accumulation in smooth muscle cell lysosomes in primate monkeys. Amer. J. Path., 78:497.

    Google Scholar 

  • Gomori, G., 1952, Microscopic Histochemistry, University of Chicago press.

    Google Scholar 

  • Gonzalez, I.E., and Furman, R.H., 1965, Histochemistry of spontaneous and experimental arterial lesions, in Comparative Atherosclerosis (J.C. Roberts, Jr., and R. Straus, eds.) pp. 329–341, Hoeber, New York.

    Google Scholar 

  • Gore, I., 1952, Pathogenesis of dissecting aneurysm of the aorta. Arch. Path., 53:142.

    Google Scholar 

  • Gore, I., and Seiwert, V.J., 1952, Dissecting aneurysm of the aorta. Arch. Path., 53:121.

    Google Scholar 

  • Gore, I., and Larkey, B.J., 1960, Functional activity of aortic mucopolysaccharides. J. Lab. Clin. Med., 56:839.

    Google Scholar 

  • Gottlob, R., and Hoff, H.F., 1968, Histochemical investigations on the nature of large blood vessel endothelial and medial argy-rophilic lines and on the mechanism of silver staining. Histochemie, 13:70.

    Article  Google Scholar 

  • Grant, R.A., 1965, Preparation of an elastin-like material from collagen by cross-linking followed by heat treatment. Bio-Chem. J., 97:5C.

    Google Scholar 

  • Grant, R.T., and Thompson, R.H.S., 1963, Cholinesterase and the nerve supply to blood vessels in the rabbit’s external ear. J. Anat. (Lond.), 97:7.

    Google Scholar 

  • Gresham, G.A., and Howard, A.N., 1961, Histogenesis of the atherosclerotic “fatty streak.” J. Atheroscler. Res., 1:413.

    Article  Google Scholar 

  • Gsell, O., 1928, Wandnekrosen der aorta als selbständige Erkrankung und ihre Beziehung zure Spontanruptur. Virchows Arch. Path. Anat., 270:1.

    Article  Google Scholar 

  • Gupta, R.K., Schuster, R., and Christian, W.D., 1972, A comparative immunohistochemical study of splenic arterial hyalinosis in health and disease. Amer. J. Path., 69:79.

    Google Scholar 

  • Hadjiisky, P., Scebat, L., and Renais, J., 1970, Aspects histo-chemiques et histoenzymatiques de l’aorta de Coturnix Coturnix (Caille) (Phasianicles). Atherosclerosis, 12:265.

    Article  Google Scholar 

  • Hadjiisky, P., Renais, J., and Scebat, L., 1973, Histochemie et histoenzymologie de l’epaissement diffus de l’intima aortique chez le lapin immunisé centre 1’aorta de rat. Paroi Artérielle, 1:145.

    Google Scholar 

  • Hadjiisky, P., Renais, J., and Scebat, L., 1975, Dévelopment et sénescence de l’aorte de rat: histochimie et histoenzymologie comparative. Atherosclerosis, 22:19.

    Article  Google Scholar 

  • Hagerman, J.S., and Gould, R.G., 1951, The in vitro interchange of cholesterol between plasma and red cells. Proc. Soc. Exp. Biol. (N.Y.), 78:329.

    Google Scholar 

  • Hale, A.J., Hall, T., and Curran, R.C. 1967, Electronmicroprobe analysis of calcium, phosphorus and sulphur in human arteries. J. Path. Bact., 93:1.

    Article  Google Scholar 

  • Hall, D.A., 1964, Elastolysis and Ageing, Thomas, Springfield, Ill.

    Google Scholar 

  • Harada, M., Isersky, C., Cuatrecasas, P., Page, D., Bladen, H.A., Eanes, E.D., Keiser, H.R., and Glenner, G.G., 1971, Human amyloid protein: chemical variability and homogeneity. J. Histochem. Cytochem., 19:1.

    Article  Google Scholar 

  • Harland, W.A., Smith, A.G., and Gilbert, J.D., 1973, Tissue reaction to atheroma lipids. J. Pathol., 111, 247.

    Article  Google Scholar 

  • Hashimoto, Y., Kobernick, S.D., 1964, Enzyme histochemistry of rabbit aorta in spontaneous lesions and after acute exercise. Proc. Soc. Exp. Biol. (N.Y.), 115:212.

    Google Scholar 

  • Hassler, O., Wirén, H., and Herbertsson, S., 1963, The elastic coat of the arterial wall studied with the aid of collagenase. Acta. Path. Scand., 57:15.

    Article  Google Scholar 

  • Hassler, O., 1970, The origin of the cells constituting arterial intimal thickening. Lab. Invest., 22:286.

    Google Scholar 

  • Hata, Y., Hower, J., and Insull, W., 1974, Cholesteryl ester-rich inclusions from human aortic fatty streak and fibrous plaque lesions of atherosclerosis. I. Crystalline properties, size and internal structure. Amer. J. Pathol., 75:423–456.

    Google Scholar 

  • Hata, Y., Shigematsu, H., Aihara, K., Yamamoto, M., Yamauchi, Y., and Oikawa, T., 1980, Cholesteryl ester-rich lipid inclusions in the development of experimental atherosclerosis in rabbits. In Atherosclerosis V (ed. by A.M. Gotto, L.C. Smith and B. Allen), Springer, Berlin, p. 529.

    Chapter  Google Scholar 

  • Hauss, W.H., Junge-Hulsing, G., and Hollander, H.J., 1962, Changes in metabolism of connective tissue associated with ageing and arterior atherosclerosis. J. Atheroscler. Res., 2:50.

    Article  Google Scholar 

  • Haust, M.D., 1965, Fine fibrils of extracellular space (microfibrils). Amer. J. Path., 47:1113.

    Google Scholar 

  • Haust, M.D., and More, R.H., 1965, Spontaneous lesions of the aorta in the rabbit, in Comparative Atherosclerosis (J.C. Roberts, Jr. and R. Straus, eds.) pp. 255–275, Hoeber, New York.

    Google Scholar 

  • Haust, M.D., More, R.H., Bencosme, S.A., and Balis, J.U., 1965, Elastogenesis in human aorta: an electron microscopic study. Exp. Molec. Path., 4:508.

    Article  Google Scholar 

  • Haust, M.D., and Geer, J.C., 1970, Mechanism of calcification in spontaneous aortic arteriosclerotic lesions of the rabbit. Amer. J. Path., 60:329.

    Google Scholar 

  • Haust, M.D., 1980, The nature of bi-and trinuclear cells in atherosclerotic lesions in man. Atherosclerosis (in press).

    Google Scholar 

  • Hebb, C.O., and Krnjević, K., 1962, The physiological significance of acetylcholine, in Neurochemistry (K.A.C. Elliott, I.H. Page and J.H. Quastel, eds.) p. 452, Thomas, Springfield, Ill.

    Google Scholar 

  • Heck, A.F., Hasuo, M., Furuse, M., Brock, M., and Dietz, H., 1976, Distribution of serum protein labelled with Evans blue in the walls of extra-and intracranial blood vessels of the cat. Atherosclerosis, 23:227.

    Article  Google Scholar 

  • Helin, G., Helin, P., and Lorenzen, I., 1970a, The aortic glyco-saminoglycans in arteriosclerosis induced by systemic hypoxia. Atherosclerosis, 12:235.

    Article  Google Scholar 

  • Helin, P., Lorenzen, I., Garbarsch, C., and Matthiessen, M.E., 1970b, Arteriosclerosis and hypoxia, Part 2. Biochemical changes in mucopolysaccharides and collagen of rabbit aorta induced by systemic hypoxia. J. Atheroscler. Res., 9:295.

    Article  Google Scholar 

  • Helin, P., Lorenzen, I., Garbarsch, C., and Matthiessen, M.E., 1971, Morphological and biochemical changes in rabbit aorta after a single dilatation injury. Circulat. Res., 29:542.

    Google Scholar 

  • Helin, P., Garbarsch, C, Mørk Hansen, T., Helin, G., Koford, B., and Lorenzen, I., 1974, Effects of hypoxia on the connective tissue of aorta and skin in rabbits. Atherosclerosis, 19:201.

    Article  Google Scholar 

  • Heller, H., Missmahl, H.-P., Sohar, E., and Gafni, J., 1964, Amyloidosis: its differentiation into peri-reticulin and peri-collagen types. J. Path. Bact., 88:15.

    Article  Google Scholar 

  • Hellung-Larsen, P., Laursen, T., Kjeldsen, K., and Astrup, P., 1968, Lactate dehydrogenase isoenzymes of aortic tissue in rabbits exposed to carbon monoxide. J. Atheroscler. Res., 8:343.

    Article  Google Scholar 

  • Heptinstall, R.H., Barkley, H., and Porter, K.A., 1958, Relative roles of blood cholesterol level and blood pressure level in the production of experimental aortic atheroma in rabbits. Angiology, 9:84.

    Article  Google Scholar 

  • Hess, R., and Stäubli, W., 1963, The development of aortic lipidosis in the rat. A correlative histochemical and electron microscopic study. Amer. J. Path., 43:301.

    Google Scholar 

  • Heughan, C, Niinikoski, J., and Hunt, T.K., 1973, Oxygen tensions in lesions of experimental atherosclerosis of rabbits. Atherosclerosis, 17:361.

    Article  Google Scholar 

  • Higginbotham, F.H., and Higginbotham, A.C., 1967, Histochemical study of beagle aorta. J. Atheroscler. Res., 7:89.

    Article  Google Scholar 

  • Hill, M., 1957, Secretion of heparin by mast cells. Nature (Lond.), 180:654.

    Article  ADS  Google Scholar 

  • Hill, M.C., 1910, Various forms of experimental arterial disease in the rabbit. Arch. Int. Med., 5:22.

    Google Scholar 

  • Hirst, A.E., Jr., and Johns, V.J., Jr., 1962, Experimental dissection of media of aorta by pressure. Circulat. Res., 10:897.

    Google Scholar 

  • Hitzeman, Jean W., 1963, Observations on the subcellular localization of oxidative enzymes with Nitro blue tetrazolium. J. Histochem. Cytochem., 11:62.

    Article  Google Scholar 

  • Hoff, H.F., 1968, A comparison of the fine structural localization of nucleoside phosphatase activity in large intracranial blood vessels and the thoracic aorta of rabbits. Histochemie, 13:183.

    Article  Google Scholar 

  • Hoff, H.F., and Gottlob, R., 1968, Uber Veranderungen der vasa vasorum bei Medionecrosis aortae. Virchows Arch. Abt. A, 345:107.

    Article  Google Scholar 

  • Hoff, H.F., 1969, Further studies on the ultrastructural localization of a magnesium dependent neutral ATPase in arteries. Histochemie, 18:210.

    Article  Google Scholar 

  • Hoff, H.F., 1970, Effect of hypoxia on phosphoesterases, oxidative and glycolytic enzymes in the rabbit common carotid artery. Histochemie, 23:244.

    Article  Google Scholar 

  • Hoff, H.F., and Gaubatz, J.W., 1975, Ultrastructural localization of plasma lipoproteins in human intracranial arteries. Virchows Arch., Abt. A, 369:111.

    Google Scholar 

  • Hoff, H.F., Jackson, R.L., and Gotto, A.M., 1976, Apolipoprotein localization in human atherosclerotic arteries, in Athero-sclerosis Drug Discovery (Day, C.E., ed.) pp. 100–120, Plenum, New York.

    Google Scholar 

  • Hoff, H.F., Heideman, C.L., Gaubatz, J.W., Scott, D.W., Titus, J.L., and Gotto, A.M., 1978, Correlation of apolipoprotein β retention with the structure of atherosclerotic plaques for human aortas. Lab. Invest., 38:560–567.

    Google Scholar 

  • Holt, S.J., and Withers, R.F.J., 1958, Studies in enzyme cytochemistry. V. An appraisal of indigogenic reactions for esterase localization. Proc Roy. Soc. B, 148:520.

    Article  ADS  Google Scholar 

  • Honour, A.J., and Mitchell, J.R.A., 1964, Platelet clumping in injured vessels. Brit. J. Exp. Path., 45:75.

    Google Scholar 

  • Horlick, L., and Katz, L.N., 1949, Regression of atherosclerotic lesions on cessation of cholesterol feeding in the chick. J. Lab. Clin. Med., 34:1427.

    Google Scholar 

  • Hosoda, Y., Suzuki, M., and O’Neal R.M., 1968, Angiolathyrism. III. Vasa vasorum in experimental dissecting aortic aneurysm. Exp. Molec Path., 9:206.

    Article  Google Scholar 

  • Hudson, J., and McCaughey, W.T.E., 1974, Mural thrombosis and atherogenesis in coronary arteries and aorta. An investigation using antifibrin and antiplatelet sera. Atherosclerosis, 19:543.

    Article  Google Scholar 

  • Hueper, W.C., 1956, Pathogenesis of atherosclerosis. Amer. J. Clin. Path., 26:559.

    Google Scholar 

  • Hundeiker, M., 1970, Demonstration of the vasa vasorum in the tunica media of the arterial wall. Angiologica, 7:1.

    Google Scholar 

  • Hurley, J.V., and Ham, Kathryn N., 1959, The nature of the connective tissue defect produced by the aminonitriles, Brit. J. Exp. Path., 40:216.

    Google Scholar 

  • Hüttner, I., Jellinek, H., Sótonyi, P., Tóth, A., and Makói, Z., 1965, Enzymhistochemische Untersuchungen der Aortaregeneration in Tierexperimenten. Acta. Histochem., 21:219.

    Google Scholar 

  • Hüttner, I., More, R.H., and Rona, G., 1970, Fine structural evidence of specific mechanism for increased endothelial permeability in experimental hypertension. Amer. J. Path., 61:395.

    Google Scholar 

  • Hüttner, I., Boutet, M., and More, R.H., 1973a, Studies on protein passage through arterial endothelium. II. Regional differences in permeability to fine structural protein tracers in arterial endothelium of normotensive rats. Lab. Invest., 28:678.

    Google Scholar 

  • Hüttner, I., Boutet, M., Rona, G., and More, R.H., 1973b, Studies on protein passage through arterial endothelium. III. Effect of blood pressure levels on the passage of fine structural protein tracers through rat arterial endothelium. Lab. Invest., 29:536.

    Google Scholar 

  • Imai, H., Werthessen, N.T., Taylor, C.B., and Lee, K.T., 1976, Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol. Arch. Path., 100:565–572.

    Google Scholar 

  • Imai, H., Werthessen, N.T., Subramanyam, V., Le Quesne, P.W., Soloway, A.H., and Kanisawa, M., 1980, Angiotoxicity of oxygenated sterols and possible precursors. Science, 207:651–653.

    Article  ADS  Google Scholar 

  • Insull, W., Hata, Y., Meakin, J.D., Marchant, L., Andrews, C.W., and Buzek, B., 1974, Morphology of cholesteryl-ester rich inclusions in lesions of atherosclerosis in man. Atherosclerosis, 19:555–560.

    Article  Google Scholar 

  • Iserksy, C, Ein, D., Page, D.L., Harada, M., and Glenner, G.G., 1972, Immunochemical cross-reactions of human amyloid proteins with human immunoglobulin light polypeptide chains. J. Immunol., 108:486.

    Google Scholar 

  • Iverius, P.-H., 1972, The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. J. Biol. Chem., 247:2607.

    Google Scholar 

  • Izuka, K., and Murata, K., 1972, Inhibitory effects of human aortic and venous acid glycosaminoglycans on thrombus formation. Atherosclerosis, 16:217.

    Article  Google Scholar 

  • Jaeger, M., 1964, The flow through the arterial wall, in Pulsatile Blood Flow (E.O. Attinger, ed.) pp. 307–322, McGraw-Hill, New York.

    Google Scholar 

  • Jager, H. de, and Stam, F.C., 1962, Pathology and histochemistry of amyloidosis in old age. Gerontologia (Basel), 6:19.

    Article  Google Scholar 

  • Janigan, D.T., 1965, Fluorochrome staining of juxta-glomerular cell granules. Arch. Path., 79:370.

    Google Scholar 

  • Jeffrey, J.J., and Martin, G.R., 1966, On the role of ascorbic acid in the biosynthesis of collagen. II. Site and nature of ascorbic acid participation. Biochim. Biophys. Acta., 121:281.

    Article  Google Scholar 

  • Jellinek, H., Nagy, Z., Hüttner, I., Bálint, A., Kóczé, A., and Kerényi, T., 1969, Investigations of the permeability changes of the vascular wall in experimental malignant hypertension by means of a colloidal iron preparation. Brit. J. Exp. Path., 50:13.

    Google Scholar 

  • Jellinek, H., 1970a, Failure of etiological differentiation of human diseases associated with fibrinoid. Angiology, 21:691.

    Article  Google Scholar 

  • Jellinek, H., 1970b, The role of the elastic membrane in the development of the two forms of vascular fibrinoid. Angiology, 21:636.

    Article  Google Scholar 

  • Jellinek, H., 1974, Arterial lesions and arteriosclerosis, pp. 112, Akadémai Kiadó, Budapest.

    Book  Google Scholar 

  • Jellinek, H., 1980, Acute and chronic alterations of arteries in hypertensive conditions. Atherogenesis 4, Suppl. III, p. 80. (2nd International Austrian Atherosclerosis Conference, Vienna, April, 1980; ed. by W. Auerswald, H. Sinzinger, and K. Widhalm).

    Google Scholar 

  • Jensen, J.G., and Bertelsen, S., 1961, Studies on histochemistry and embryogenesis of foetal elastic fibres. Acta. Path. Scand., 51:241.

    Article  Google Scholar 

  • Jones, D.B., 1974, Arterial and glomerular lesions associated with severe hypertension: light and electronmicroscopic studies. Lab. Invest., 31:303.

    Google Scholar 

  • Joris, I., Stetz, E., and Majno, G., 1979, Lymphocytes and monocytes in the aortic intima. Atherosclerosis, 34:221–231.

    Article  Google Scholar 

  • Juhlin, L., and Shelley, W.B., 1966, Detection of histamine by a new fluorescent o-phthaldehyde stain. J. Histochem. Cytochem., 14:525.

    Article  Google Scholar 

  • Jurrus, E.R., and Weiss, H.S., 1977, In vitro oxygen tensions in the rabbit aortic arch. Atherosclerosis, 28:223.

    Article  Google Scholar 

  • Kádár, A., Gardner, D.L., and Bush, V., 1972, Glycosaminoglycans in developing chick-embryo aorta revealed by ruthenium red: an electron microscope study. J. Path., 108:275.

    Article  Google Scholar 

  • Kanabrocki, E.L., Fells, I.G., Decker, C.F., and Kaplan, E., 1963, Total hexosamine, sulfur and nitrogen levels in human aortae. J. Gerontol., 18:18.

    Google Scholar 

  • Kao, V.C.Y., and Wissler, R.W., 1965, A study of the immunohisto-chemical localization of serum lipoproteins and other plasma proteins in human atherosclerotic lesions. Exp. Molec. Path., 4:465.

    Article  Google Scholar 

  • Kaplan, D., and Meyer, K., 1960, Mucopolysaccharides of aorta at various ages. Proc. Soc. Exp. Biol. (N.Y.), 105:78.

    Google Scholar 

  • Karrer, H.E., 1961, An electronmicroscope study of the aorta in young and in ageing mice. J. Ultrastruct. Res., 5:1.

    Article  Google Scholar 

  • Katayama, Y., and Ende, N., 1965, Esterase studies on dog mast-cell tumours. Nature (Lond.), 205:190.

    Article  ADS  Google Scholar 

  • Katz, S.S., Shipley, G.G., and Small, D.M., 1976, Physical chemistry of the lipid of human atherosclerotic lesions: demonstration of a lesion intermediate between fatty streaks and advanced plaques. J. Clin. Invest., 58:200–211.

    Article  Google Scholar 

  • Keech, M.K., 1960, Electron microscope study of elastase digested rat aorta. Gerontologia, 4:1.

    Article  Google Scholar 

  • Keeley, F.W., and Partridge, S.M., 1974, Aminoacid composition and calcification of human aortic elastin. Atherosclerosis, 19:287.

    Article  Google Scholar 

  • Keith, D.A., Paz, M.A., and Gallop, P.M., 1977, Elastic tissue histochemistry. Adv. Exp. Med. Biol., 79:57.

    Google Scholar 

  • Kennedy, J.S., 1962, Sulphur-35 in experimental amyloidosis. J. Path. Bact., 83:165.

    Article  Google Scholar 

  • Kerényi, T., Jellinek, H., Huttner, I., Gorácz, G., and Konyár, E., 1966, Fibrinoid necrosis of the vascular wall in experimental malignant hypertension. Acta. Morphol. Hungary, 14:175.

    Google Scholar 

  • Kerényi, T., and Jellinek, H., 1972, Fibrin deposition in smooth muscle cells of muscular type small arteries under temporary conditions of hypoxia. Exp. Molec. Path., 17:1.

    Article  Google Scholar 

  • Kim, I.C., Shirahama, T., and Cohen, A.S., 1967, The lipid content of amyloid fibrils purified by a variety of methods. Amer. J. Path., 50:869.

    Google Scholar 

  • Kimmelstiel, P., and Wilson, C., 1936, Intercapillary lesions in the glomeruli of the kidney. Amer. J. Path., 12:83.

    Google Scholar 

  • Kimmelstiel, P., Osawa, G., and Beres, J., 1966, Glomerular basement membrane in diabetics. Amer. J. Clin. Path., 45:21.

    Google Scholar 

  • Kirk, J.E., and Laursen, T.J.S., 1955, Diffusion coefficients of various solutes for human aortic tissue. With special reference to variation in tissue permeability with age. J. Gerontol., 10:288.

    Google Scholar 

  • Kirk, J.E., 1959, Mucopolysaccharides of arterial tissue, in The Arterial Wall (A.I. Lansing, ed.) pp. 161–191, Baillére, Tindall and Cox, London.

    Google Scholar 

  • Kirk, J.E., 1963, Intermediary metabolism of human arterial tissue and its changes with age and atherosclerosis, in Atherosclerosis and Its Origin (M. Sandler and G.H. Bourne, eds.) pp. 67–117, Academic Press, New York.

    Google Scholar 

  • Kirk, J.E., 1969, Enzymes of the Arterial Wall. Academic Press, New York.

    Google Scholar 

  • Kjeldsen, K., Wanstrup, J., and Astrup, P., 1968, Enhancing effect of arterial hypoxia on the development of atheromatosis. J. Atheroscler. Res., 8:835.

    Article  Google Scholar 

  • Klynstra, F.B., and Böttcher, C.J.F., 1970, Permeability patterns in the pig aorta. Atherosclerosis, 11:451.

    Article  Google Scholar 

  • Klynstra, F.B., 1974, On the passage restricting role of acid mucopolysaccharides in the endothelium of pig aortas. Atherosclerosis, 19:215.

    Article  Google Scholar 

  • Knieriem, H-J., 1970, Immunohistochemical studies on the significance of smooth muscle cells in the pathohistogenesis of human arteriosclerosis. Beit, z. Pathol., 141:4.

    Google Scholar 

  • Koelle, G.B., 1955, The histochemical identification of acetylcholinesterase in cholinergic, adrenergic and sensory neurons. J. Pharmacol., 114:167.

    Google Scholar 

  • Koelle, G.B., 1962, A new general concept of the neurohumoral functions of acetylcholine and acetylcholinesterase. J. Pharm. Pharmacol., 14:65.

    Article  Google Scholar 

  • Kofoed, J.A., and Robertson, W. Van B., 1966, Ascorbic acid and the synthesis of chondroitin sulphate. Biochim. Biophys. Acta., 124:86.

    Article  Google Scholar 

  • Koide, R., and Pollak, O.J., 1963, Cytochemical studies of rabbit aortic cells in tissue culture. J. Histochem. Cytochem., 11:265.

    Article  Google Scholar 

  • Kormano, M., 1967, Dye permeability and alkaline phosphatase activity of testicular capillaries in the post natal rat. Histochemie, 9:327.

    Article  Google Scholar 

  • Kramsch, D.M., Franzblau, C, and Hollander, W., 1971, The protein and lipid composition of arterial elastin and its relationship to lipid accumulation in the atherosclerotic plaque. J. Clin. Invest., 50:1666.

    Article  Google Scholar 

  • Kramsch, D.M., and Hollander, W., 1973, The interaction of serum and arterial lipoproteins with elastin of the arterial intima and its role in lipid accumulation in atherosclerotic plaques. J. Clin. Invest., 52:236.

    Article  Google Scholar 

  • Krut, L.H., 1979, Atherosclerosis: a process determined primarily by the physical state of plasma lipid that has entered the arterial wall. Medical Hypotheses, 5:533.

    Article  Google Scholar 

  • Krut, L.H., 1980, The missing link in the evolution of coronary heart disease: a consequence of modern technology in food-handling. In VII International Symposium on Drugs Affecting Lipid Metabolism, Milan, p. 144.

    Google Scholar 

  • Kumar, V., Berenson, G.S., Ruiz, M., Dalfares, E.R., and Strong, J.P., 1967a, Acid mucopolysaccharides of human aorta. Part 1. Variations with maturation. J. Atheroscler. Res., 7:573.

    Article  Google Scholar 

  • Kumar, V., Berenson, G.S., Ruiz, M., Dalfares, E.R., and Strong, J.P., 1967b, Acid mucopolysaccharides of human aorta. Part 2. Variations with atherosclerotic involvement. J. Atheroscler. Res., 7:583.

    Article  Google Scholar 

  • Kunnert, B., and Krug, H., 1974, Cholesterolester und phospholipide in der arteriosklerotischen Aorta. Histochromatographische Untersuchungen. Exp. Path., 9:48.

    Google Scholar 

  • Kurozumi, T., Tanaka, K., and Yae, Y., 1978, Hypertension-induced cerebral atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis, 30:137–145.

    Article  Google Scholar 

  • Kwaan, H.C., 1964, A histochemical study of fibrinolytic activity and content of protease in mast cells. Amer. J. Clin. Path., 41:604.

    Google Scholar 

  • Kwaan, H.C., and Astrup, T., 1965, Fibrinolytic activity in thrombosed veins. Circulat. Res., 17:477.

    Google Scholar 

  • Labella, F.S., 1958, Characterization of Schiff-positive substances in elastic fibers. J. Histochem. Cytochem., 6:260.

    Article  Google Scholar 

  • Labella, F.S., 1962, Separation of fluorescent and pigmented components of elastin: possible relation to age pigments and certain invertebrate pigments. J. Gerontol., 17:8.

    Google Scholar 

  • Labella, F.S., and Vivian, S., 1967, Aminoacid composition of elastin in the developing human aorta. Biochim. Biophys. Acta., 133:189.

    Google Scholar 

  • Labella, F., Keeley, F., Vivian, S., and Thornhill, D., 1967, Dityrosine in elastin in chick embryo. Transient occurrence in human foetus. Biochem. Biophys. Res. Commun., 26:748.

    Article  Google Scholar 

  • Lagunoff, D., and Benditt, E.P., 1961, Histochemical examinations of chymotrypsin-like esterases. Nature (Lond.), 192:1198.

    Article  ADS  Google Scholar 

  • Lagunoff, D., Phillips, M., and Benditt, E.P., 1961, The histochemical demonstration of histamine in mast cells. J. Histochem. Cytochem., 9:534.

    Article  Google Scholar 

  • Lalich, J.J., and Ishida, K., 1966, Alterations in elastin and orientation of collagen in angiolathyrism. Arch. Path., 82:129.

    Google Scholar 

  • Landers, J.W., Chason, J.L., Gonzalez, J.E., and Palutke, W., 1962, Morphology and enzymatic activity of rat cerebral capillaries. Lab. Invest., 11:1253.

    Google Scholar 

  • Lansing, A.I., Roberts, E., Ramasarma, G.B., Rosenthal, T.B., and Alex, M., 1951, Changes with age in aminoacid compositions of arterial elastin. Proc. Soc. Exp. Biol. (N.Y.), 76:714.

    Google Scholar 

  • Lansing, A.I., Rosenthal, T.B., Alex, M., and Dempsey, E.W., 1952, The structure and chemical characterisation of elastic fibres as revealed by elastase and electronmicroscopy. Anat. Rec., 114:555.

    Article  Google Scholar 

  • Leathes, J.B., 1925, Role of fats in vital phenomena. Lecture III. Lancet, i:957.

    Article  Google Scholar 

  • Lee, M.T., Imai, H., Werthessen, N.T., and Taylor, C.B., 1974, Necrogenic agent obtained from cholesterol used in dietary experiments. Atherosclerosis III, Springer, Berlin, pp. 344–347.

    Chapter  Google Scholar 

  • Lehmann, H., and Silk, E., 1953, Succinylmonocholine. Brit. Med. J., i:767.

    Article  Google Scholar 

  • Lehner, T., 1965, Juxtaglomerular apparatus staining with thio-flavine T fluorchrome, and its confusion with amyloid. Nature (Lond.), 206:738.

    Article  ADS  Google Scholar 

  • Lehtonen, A., Näntö, V., and Kulonen, E., 1964, Method for the identification of the origin of fibrinoid and other insoluble proteins. Acta. Path. Scand., 62:151.

    Google Scholar 

  • Leites, F.L., 1969, Activity of lipolytic enzymes in atherosclerosis. Fed. Proc., 23:T565.

    Google Scholar 

  • Lendrum, A.C., 1961, Further observations on fibrinous vasculosis. Med. Tijdschr. Geneesk., 105:1359.

    Google Scholar 

  • Lendrum, A.C., Fraser, D.C., Slidders, W., and Henderson, R., 1962, Studies on the character and staining of fibrin. J. Clin. Path., 15:401.

    Article  Google Scholar 

  • Lendrum, A.C., 1963, The hypertensive diabetic kidney as a model for the so-called collagen diseases. Canad. Med. Ass. J., 88:442.

    Google Scholar 

  • Lendrum, A.C., 1967, Deposition of plasmatic substances in vessel walls. Path. Microbiol., 30:681.

    Google Scholar 

  • Lendrum, A.C., Slidders, W., Fraser, D.S., 1972, Renal hyalin. A study of amyloidosis and diabetic fibrinous vasculosis with new staining methods. J. Clin. Path., 25:373.

    Article  Google Scholar 

  • Lent, R., and Franzblau, C., 1967, Studies on the reduction of bovine elastin: evidence for the presence of △ 6,7 — dehydrolysinonorleucine. Biochem. Biophys. Res. Commun., 26:43.

    Article  Google Scholar 

  • Levene, C.I., 1961, Collagen as a tensile component of the developing chick aorta. Brit. J. Exp. Path., 42:89.

    Google Scholar 

  • Levene, C.I., 1962, Studies on the mode of action of lathyrogenic compounds. J. Exp. Med., 116:119.

    Article  Google Scholar 

  • Levene, C.I., 1966, Collagen and lathyrism. Proc. Roy. Soc. Med., 59:757.

    Google Scholar 

  • Levin, M., Franklin, E.C., Frangione, B., Pras, M., 1972, The aminoacid sequence of a major non-immunoglobulin component of some amyloid fibrils. J. Clin. Invest., 51:2773–6.

    Article  Google Scholar 

  • Lillie, R.D., 1958, Acetylation and nitrosation of tissue amines in histochemistry. J. Histochem. Cytochem., 6:352.

    Article  Google Scholar 

  • Lillie, R.D., 1964, Histochemical acylation of hydroxyl and amino groups. Effect of the periodic acid Schiff reaction, anionic and cationic dye and Van Gieson collagen stains. J. Histochem. Cytochem., 12:821.

    Article  Google Scholar 

  • Lillie, R.D., Pizzolato, P., and Donaldson, P.T., 1972, Elastin IV. Lysinal aldehyde relations, blocking and extraction tests, staining mechanisms. Acta. Histochem. Bd, 44:215.

    Google Scholar 

  • Lillie, R.D., Pizzolato, P., and Strong, J.P., 1976, Ageing effects of vascular elastica staining by oil soluble nigrosin dyes. Virchows Arch., Abt. A, 371:323.

    Google Scholar 

  • Lindy, S., Turto, H., Vitto, J., Garbarsch, C, Helin, P., and Lorenzen, I., 1974, The effect of chronic hypoxia on lactate dehydrogenase in rabbit arterial wall. Biochemical studies on normal and injured aortas. Atherosclerosis, 20:295.

    Article  Google Scholar 

  • Linker, A., Hoffman, P., Sampson, P., and Meyer, K., 1958, Heparitin sulphate. Biochim. Biophys. Acta., 29:443.

    Article  Google Scholar 

  • Loeven, W.A., 1963, The enzymes of the elastase complex, in International Review of Connective Tissue Research (D.A. Hall, ed.) Vol. 1, pp. 183–240, Academic Press, New York.

    Google Scholar 

  • Loeven, W.A., 1964, The possible implications of the enzymes of the elastase complex in the process of atherosclersis. Paper read to Colloque portant sur 1’Enzymologie et l’Immunologie (plus specialement sur l’Élastase et Corps Derivés) dans l’Atherosclerosis, October 1964, Faculté de Medicine de Bordeaux.

    Google Scholar 

  • Loeven, W.A., 1965, Elastolysis III. The release of carbohydrate moieties during the incubation of acid-and alkali-treated elastin with the enzymes of the elastase complex. Acta. Physiol. Pharmacol. Neerl., 13:278.

    Google Scholar 

  • Loeven, W.A., 1970, Susceptibility of various kinds of elastin to elastolytic enzymes, trypsin and chymotrypain. Clin. Chim. Acta., 27:521.

    Article  Google Scholar 

  • Loewi, G., Glynn, L.E., and Dorling, J., 1960, Studies on the nature of collagen degeneration. J. Path. Bact., 80:1.

    Article  Google Scholar 

  • Lojda, Z., and Felt, V., 1960, The histochemistry of dehydrogenase systems in the aortae of rabbits with experimental atherosclerosis. Experientia, 16:514.

    Article  Google Scholar 

  • Lojda, Z., and Zemplényi, T., 1961, Histochemistry of some enzymes of the vascular wall in experimental rabbit atheromatosis. J. Atheroscler. Res., 1:101.

    Article  Google Scholar 

  • Lojda, Z., 1962, The enzyme topochemistry of the arterial wall. Československá morfologie, 10:46.

    Google Scholar 

  • Lojda, Z., 1965, Remarks on histochemical demonstration of dehydrogenases. II. Intracellular localization. Folia morphologica, 13:84.

    Google Scholar 

  • Lojda, Z., and Frič, P., 1966, Lactic dehydrogenase isoenzymes in the aortic wall. J. Atheroscler. Res., 6:264.

    Article  Google Scholar 

  • Lojda, Z., 1974, Topochemie β-glykosidaz v aortách a Koronárnich arteruch krys, morcat a Kraliku za normalriho stavu a po cholesterolovem Ziru. Cesk. Patol., 10:1.

    Google Scholar 

  • Lojda, Z., Gossrau, R., and Schiebler, T.H., 1976, Enzym-histo-chemische Methoden. Springer, Berlin.

    Google Scholar 

  • Lojda, Z., Horakova, J., Nadvornik, F., and Reinis, Z., 1977, Glycosidases of the arterial wall. Acta. Unit. Carol. Med., Suppl. 79, part III, pp. 107–116.

    Google Scholar 

  • Lojda, Z., 1978, Localization of some peptidases in the vascular wall. Abstracts, 11th Internat. Congress Angiology, Prague, p. 278.

    Google Scholar 

  • Loomeijer, F.J., 1961, The lipid compound of elastin. J. Atheroscler. Res., 1:62.

    Article  Google Scholar 

  • Lorenzen, I., 1963, Repair processes in arterial tissue. Biochemical alterations in rabbit aorta induced by norepinephrine. Circulat. Res., 12:449.

    Google Scholar 

  • Lorenzen, I., and Helin, I., 1967, Arteriosclerosis induced by hypoxia. Acta. Path. Scand., 69:158.

    Article  Google Scholar 

  • Lovell, D., Clark, A.E., and Curran, R.C., 1966, Formation of acid mucopolysaccharides by fibroblasts and serosal cells. Nature (Lond.), 210:1173.

    Article  ADS  Google Scholar 

  • Luciano, L., Junger, E., and Reale, E., 1968, Glycogen in smooth muscle cells of mammalian vessel walls. Electron microscopical and spectrophotometrical studies. Histochemie, 15:219.

    Article  Google Scholar 

  • Lunseth, J.H., 1963, Elastic membrane: Effect of increasing tension on the absorptive capacity. Science, 141:438.

    Article  ADS  Google Scholar 

  • McAlpine, J.C., and Fuller, A.P., 1964, Histochemistry of fresh frozen material in localized laryngeal amyloidosis. J. Path. Bact., 88:455.

    Article  Google Scholar 

  • McAlpine, J.C., 1965, Histochemical survival of diaphorase activity in formalin-fixed tissues stored for 18 months in cold gum-sucrose. J. Histochem. Cytochem., 13:296.

    Article  Google Scholar 

  • McCullum, H.G., 1965, Experimental lathyrism in mice. J. Path. Bact., 89:625.

    Article  Google Scholar 

  • McClurkin, I.T., 1964, A method for the cytochemical demonstration of sodium-activated adenosine triphosphatase. J. Histochem. Cytochem., 12:654.

    Article  Google Scholar 

  • McCullagh, K.G., 1973, Studies on elephant aortic elastic tissue. Part 1. The histochemistry and fine structure of the fibres. Exp. Molec. Path., 18:190.

    Article  Google Scholar 

  • McCullagh, K.G., Derouette, S., and Robert, L., 1973, Studies on elephant aortic elastic tissue. Part II. Aminoacid analysis, structural glycoproteins and antigenicity. Exp. Molec. Path., 18:202.

    Article  Google Scholar 

  • McCullagh, K.G., Duance, V.C., and Bishop, K.A., 1980, The distribution of collagen types I, III and V (AB) in normal and J. Pathol., 130:45–55.

    Article  Google Scholar 

  • MacFarlane, R.G., 1964, The development of ideas on fibrinolysis. Brit. Med. Bull., 20:173.

    Google Scholar 

  • McGill, H.C., Jr., Frank, M.H., and Geer, J.C., 1961, Aortic lesions in hypertensive monkeys. Arch. Path., 71:96.

    Google Scholar 

  • McKinney, B., and Grubb, C., 1965, Non-specificity of thioflavine T as an amyloid stain. Nature (Lond.), 205:1023.

    Article  ADS  Google Scholar 

  • McKinney, B., 1970, Hyaline arteriosclerosis in wild animals. J. Comp. Path., 80:275.

    Article  Google Scholar 

  • McLetchie, N.G.B., 1952, Pathogenesis of atheroma. Amer. J. Path., 28:413.

    Google Scholar 

  • McLoughlin, C.B., 1964, Biological role of the connective tissue matrix, in Biological Aspects of Occlusive Vascular Disease. (D.G. Chalmers and G.A. Gresham, eds.) pp. 121–130, Cambridge University Press.

    Google Scholar 

  • Maggi, V., and Brander, W., 1963, A histochemical study of the bound lipids of the arterial wall. Biochem. J., 89:28P.

    Google Scholar 

  • Manalo-Estrella, P., and Barker, A.E., 1967, Histopathologic findings in human aortic media associated with pregnancy. Arch. Path., 83:336.

    Google Scholar 

  • Mancini, R.E., Vilar, O., Stein, E., and Fiorini, H., 1961, A histochemical and radioautographic study of the participation of fibroblasts in the production of mucopolysaccharides in connective tissue. J. Histochem. Cytochem., 9:278.

    Article  Google Scholar 

  • Manley, G., 1965, Changes in vascular mucopolysaccharides with age and blood pressure. Brit. J. Exp. Path., 46:125.

    Google Scholar 

  • Manley, G., and Burns, J., 1965, Muscle changes in cystic medial necrosis of the iliac arteries. J. Path. Bact., 89:525.

    Article  Google Scholar 

  • Manley, G., and Hawksworth, J., 1965, Distribution of mucopolysaccharides in the human vascular tree. Nature (Lond.), 206: 1152.

    Article  ADS  Google Scholar 

  • Manley, G., and Levene, C.I., 1967, β-aminopropionitrile and the mucopolysaccharides of embryonic chick aortae. Nature (Lond.), 214:729.

    Article  ADS  Google Scholar 

  • Martin, G.M., Sprague, C.A., Norwood, T.H., and Pendergrass, W.R., 1974, Clonal selection, attenuation and differentiation in an in vitro model of dyperplasia. Amer. J. Path., 74:137–154.

    Google Scholar 

  • Martinazzi, M., Capella, C., and Carnevali, L., 1968, Early sudanophilic lesions in femoral-popliteal and coronary arteries-a comparative macroscopic and histochemical study. J. Atheroscler. Res., 8:657.

    Article  Google Scholar 

  • Massman, J., and Oesterich, S., 1974, Angiometric studies of human coronary artery sclerosis. Atherosclerosis, 2:287

    Article  Google Scholar 

  • Matthews, M.B., and Decker, L., 1968, The effect of acid mucopolysaccharides and acid mucopolysaccharide-proteins on fibril formation from collagen solutions. Biochem. J., 109:517.

    Google Scholar 

  • Mechanic, G., and Tanzer, M.L., 1970, Biochemistry of collagen crosslinking. Isolation of a new cross-link hydroxylysino-hydroxynorleucine. Biochem. Biophys. Res. Commun., 41:1597.

    Article  Google Scholar 

  • Mellors, R.C., and Ortega, L.G., 1956, Analytical pathology. III. New observations on the pathogenesis of glomerulo-nephritis, lipid nephrosis, periarteritis nodosa and secondary amyloidosis in man. Amer. J. Path., 32:455.

    Google Scholar 

  • Mellors, R.C., Ortega, L.G., and Holman, H.R., 1957, Role of gamma globulins in pathogenesis of renal lesions in systemic lupus erythematosus and chronic membranous glomerulonephritis, with an observation on the lupus erythematosus cell reaction. J. Exp. Med., 106:191.

    Article  Google Scholar 

  • Menzies, D.W., and Roberts, J.T., 1963, Effect of age on the acidophilia of aortic elastin. Nature (Lond.), 198:1006.

    Article  ADS  Google Scholar 

  • Merrilees, M.J., Merrilees, M.A., Birnbaum, P.S., Scott, P.J., and Flint, M.H., 1977, The effect of centrifugal force on glyco-saminoglycan production of aortic smooth muscle cells in culture. Atherosclerosis, 27:259:264.

    Article  Google Scholar 

  • Meyer, W.W., 1950, Interstitiell Fibrinöse Entzündung im Formenkreis dysorischer Vorgänge. Klin. Wochschr., 28:697.

    Article  Google Scholar 

  • Meyer, W.W., and Stelzig, H.H., 1969, Calcification patterns of the internal elastic membrane. Calc. Tiss. Res., 3:266.

    Article  Google Scholar 

  • Milch, L.J., and Loxterman, P.B., 1964, Aortal mucopolysaccharide changes after epinephrine administration in rabbits. Proc. Soc. Exp. Biol., (N.Y.), 116:1125.

    Google Scholar 

  • Miller, B.F., Aiba, T., Keyes, F.P., Curreri, P.W., and Branwood, A.W., 1966, Beta-glucuronidase activity and its variation with pH in human atherosclerotic arteries. J. Atheroscler. Res., 6:352.

    Article  Google Scholar 

  • Miller, B.F., and Kothari, H.V., 1969, Increased activity of lysosomal enzymes in human atherosclerotic aortas. Exp. Molec. Path., 10:288.

    Article  Google Scholar 

  • Miller, G.J., and Miller, N.E., 1975, Plasma high-density lipoprotein concentration and development of ischaemic heart disease. Lancet, i:16.

    Article  Google Scholar 

  • Minick, C.R., and Murphy, G.E., 1974, Immunologic injury and atherosclerosis. Adv. Exp. Med. Biol., 43:355–74.

    Google Scholar 

  • Minick, C.R., Stemerman, M.B., and Insull, W., 1979, Role of endothelium and hypercholesterolemia in intimal thickening and lipid accumulation. Amer. J. Pathol., 95:131–158.

    Google Scholar 

  • Mitchell, J.R.A., and Adams, J.H., 1977, Aortic size and aortic calcification. Atherosclerosis, 27:437.

    Article  Google Scholar 

  • Montgomery, P. O’B., and Muirhead, E.E., 1953, Similarities between the lesions in human malignant hypertension and in the hypertensive state of the nephrectomized dog. Amer. J. Path., 29:1147.

    Google Scholar 

  • Montgomery, P. O’B., and Muirhead, E.E., 1957, A differentiation of certain types of fibrinoid and hyaline. Amer. J. Path., 33:285.

    Google Scholar 

  • Moon, H.D., and Rinehart, J.F., 1952, Histogenesis of coronary arteriosclerosis. Circulation, 6:481.

    Google Scholar 

  • Morin, R.J., and Bernick, S., 1963, Acid mucopolysaccharides of the arterial wall in essential fatty acid deficiency. Amer. J. Path., 43:337.

    Google Scholar 

  • Morris, C.J., Bradby, G.V.H., and Walton, K.W., 1978, Fibrous long spacing collagen in human atherosclerosis. Atherosclerosis, 31:345–354.

    Article  Google Scholar 

  • Movat, H.Z., 1958, The concept of fibrinoid. Amer. J. Med. Sci., 236:373.

    Google Scholar 

  • Mowry, R.W., and Scott, J.E., 1967, Observations on the basophilia of amyloids. Histochemie, 10:8.

    Article  Google Scholar 

  • Mrhová, O., Zemplényi, T., and Lojda, Z., 1963a, β-glucuronidase activity of the aorta in early stages of experimental rabbit atherosclerosis. J. Atheroscler. Res., 3:44.

    Article  Google Scholar 

  • Mrhová, O., Zemplényi, T., and Lojda, Z., 1963b, The effect of cholesterol fat feeding on the activity of rabbit aorta dehydrogenase systems. Quart. J. Exp. Physiol., 48:61.

    Google Scholar 

  • Muir, H., 1964, The chemistry of mucopolysaccharides of arteries, in Biological Aspects of Occlusive Vascular Disease (D.G. Chalmers and G.A. Gresham, eds.) pp. 60–75, Cambridge University Press.

    Google Scholar 

  • Muirhead, E.E., Montgomery, P.O’B., and Booth, E., 1956, The glomerular lesions of diabetes mellitus. Cellular hyaline and acellular hyaline of “intercapillary glomerulosclerosis” as depicted by histochemical studies. Arch. Int. Med., 98:146.

    Article  Google Scholar 

  • Munz, K., and Meves, C., 1974, Digestibility of elastic fibers by elastase in semifine and fine sections as a function of fixation mode and embedding media. Histochemistry, 40:181.

    Article  Google Scholar 

  • Murata, K., and Kirk, J.E., 1962, Sialic acid content of human arterial and venous tissue. J. Atheroscler. Res., 2:452.

    Article  Google Scholar 

  • Murata, K., Kirk, J.E., and Asawa, G., 1964, Acid mucopolysaccharides of human aortic adventitia. Nature (Lond.), 202:1334.

    Article  ADS  Google Scholar 

  • Murata, K., Nakazawa, K., and Hamai, A., 1975, Distribution of acidic glycosaminoglycans in the intima, media and adventitia of bovine aorta and their anticoagulant properties. Atherosclerosis (in press).

    Google Scholar 

  • Murata, K., Izuka, K., and Nakazawa, K., 1978, Effect of human aortic acidic glycosaminoglycans on partial thromboplastin time. Atherosclerosis, 29:95.

    Article  Google Scholar 

  • Murphy, J.R., 1962, Erythrocyte metabolism. IV. Equilibration of cholesterol-4-C14 between erythrocytes and variously treated sera. J. Lab. Clin. Med., 60:571.

    Google Scholar 

  • Muruffo, C.A., and Portman, O.W., 1968, Nutritional control of coronary artery atherosclerosis in the squirrel monkey. J. Atheroscler. Res., 8:237.

    Article  Google Scholar 

  • Mustard, J.F., 1970, Introduction to the platelet and the artery Atherosclerosis, Proceeding of the Second International Symposium, (ed. by R.J. Jones) Springer, Berlin, pp. 76–79.

    Google Scholar 

  • Nachlas, M.M., and Seligman, A.M., 1949, The comparative distribution of esterase in the tissues of five mammals by a histo-chemical technique. Anat. Rec., 105:677.

    Article  Google Scholar 

  • Nakamura, M., Tshihara, Y., Sata, T., and Yabuta, N., 1966, Acid mucopolysaccharides and lipids of Japanese arteries, with special reference to the absence of hyaluronic acid in Japanese cerebral arteries. J. Atheroscler. Res., 6:132.

    Article  Google Scholar 

  • Nakamura, M., Torii, S., Yatsuki, K., Kikuchi, Y., and Yamamoto, H., 1971, Cerebral atherosclerosis in Japanese. Part 1. Lipids and glycosaminoglycans in cerebral arteries. Atherosclerosis, 13:185.

    Article  Google Scholar 

  • Nakao, K., and Angrist, A.A., 1968, A histochemical demonstration of aldehyde in elastin. Amer. J. Clin. Path., 49:65.

    Google Scholar 

  • Navaratnam, V., and Palkama, A., 1966, Cholinesterases in the walls of the great arterial trunks and coronary arteries. Acta. Anat., 63:445.

    Article  Google Scholar 

  • Nedergaard, O.A., Vagne, A., and Bevan, J.A., 1969, Distribution of norepinephrine uptake within rabbit aorta between adventitia and media. Experientia, 25:150.

    Article  Google Scholar 

  • Neumark, T., and Farkas, K., 1965, Submicroscopic changes of the aortic structure in lathyrus-fed rats. Acta. Morphol. Hungary, 13:269.

    Google Scholar 

  • Newman, D.L., Gosling, R.G., and Bowden, N.L.R., 1971, Changes in aortic distensibility and area ratio with the development of atherosclerosis. Atherosclerosis, 14:231.

    Article  Google Scholar 

  • Niinikoski, J., Heughan, C., and Hunt, T.K., 1973, Oxygen tensions in the aortic wall of normal rabbits. Atherosclerosis, 17:353.

    Article  Google Scholar 

  • Nordlie, R.C., Wright, D.S., Boyum, G.P., and Rohs, J.L., 1968, Inorganic pyrophosphatase of dog aorta. Proc. Soc. Exp. Biol. (N.Y.), 128:1039.

    Google Scholar 

  • Novikoff, A.B., 1959, Enzyme cytochemistry: pitfalls in the current use of tetrazolium techniques. H. Histochem. Cytochem., 7:301.

    Google Scholar 

  • Novikoff, A.B., 1963, Electron transport enzymes: biochemical and tetrazolium staining studies, in Histochemistry and Cytochemistry (Proc. 1st Internat. Cong.) (R. Wegmann, ed.) pp. 465–481, Pergamon Press, Oxford.

    Google Scholar 

  • Numano, F., Kuroiwa, T., Kobayaski, M., Yamasawa, S., and Shimamoto, T., 1973, Phosphorylase activity in the arterial wall. Atherosclerosis, 17:321.

    Article  Google Scholar 

  • Obaze, D.E., and Wright, H.P., 1968, A modified technique for producing “en face” (Häutchen) preparations of endothelium for autoradiography. J. Atheroscler. Res., 8:861.

    Article  Google Scholar 

  • Ogawa, T., Koerten, H.K., and Daems, W.Th., 1978, Peroxidatic activity in monocytes and tissue macrophages of mice. Cell and Tissue Research, 188:361–373.

    Article  Google Scholar 

  • Ogston, A.G., and Sherman, T.F., 1961, Effects of hyaluronic acid upon diffusion of solutes and flow of solvents. J. Physiol. (Lond.), 156:67.

    Google Scholar 

  • Oka, M., Girerd, R.J., Brodie, S.S., and Angrist, A., 1966, Cardiac valve and aortic lesions in beta-aminopropionitrile fed rats with and without high salt. Amer. J. Path., 48:45.

    Google Scholar 

  • Oka, M., and Angrist, A., 1967, Histoenzymic studies of vessels in hypertensive rats. Lab. Invest., 16:25.

    Google Scholar 

  • Oka, M., Brodie, S.S., and Angrist, A.A., 1968, Sex dependent vascular changes in young, adult, aged and hypertensive rats. Amer. J. Path., 53:127.

    Google Scholar 

  • Okinaka, S., and Yoshikawa, M., 1962, Histochemical studies on the autonomic nervous system, in Proc. IV Internat. Congr. Neuropathology (H. Jakob, ed.) Vol. 1, pp. 180–187, Tieme Stuttgart.

    Google Scholar 

  • Olsen, F., 1968, Penetration of circulating fluorescent proteins into walls of arterioles and venules in rats with intermittent acute angiotensin-hypertension. Acta. Path. Scand., 74:325.

    Article  Google Scholar 

  • Olsen, F., 1969, Arteriolar permeability and destruction of elastic membrane in hypertension. Acta. Path. Scand., 75:527.

    Google Scholar 

  • Olsen, T.S., Ørksov, H., and Lundbäck, K., 1966, Kidney lesions in rats with severe long-term alloxan diabetes. 2. Histochemical studies. Comparison with human diabetic glomerular lesions. Acta. Path. Scand., 66:1.

    Article  Google Scholar 

  • Ooneda, G., Ooyama, Y., Matsuyama, K., Takatama, M., Yoshida, Y., Sikiguchi, M., and Arai, I., 1965, Electron microscopic studies on the morphogenesis of fibrinoid degeneration in the mesenteric arteries of hypertensive rats. Angiology, 16:8.

    Article  Google Scholar 

  • Ophüls, W.O., 1907, Spontaneous arteriosclerosis of the aorta (atheroma) in a rabbit. J. Amer. Med. Assoc., 48:326.

    Article  Google Scholar 

  • Osborn, G.R., 1963, The Incubation Period of Coronary Thrombosis, pp. 16, 34, 36, 45, 106, and 190, Butterworths, London.

    Google Scholar 

  • Owens, G.K., and Hollis, T.M., 1979, Relationship between inhibition of aortic histamine formation, aortic albumin permeability and atherosclerosis. Atherosclerosis, 34:365–373.

    Article  Google Scholar 

  • Paegle, R.D., 1969, Ultrastructure of calcium deposits in arteriosclerotic human aortas. J. Ultrastruct. Res., 26:412.

    Article  Google Scholar 

  • Page, D.L., Isersky, C., Harada, M., and Glenner, G.G., 1972, Immunoglobulin origin of localized nodular pulmonary amyloidosis. Res. Exp. Med., 159:75.

    Article  Google Scholar 

  • Page, R.C., and Benditt, E.P., 1967, Molecular diseases of connective and vascular tissue. II. Amine oxidase inhibition by the lathyrogen, β-aminopropionitrile. Biochemistry, 6:1142.

    Article  Google Scholar 

  • Page, R.C., and Benditt, E.P., 1968, The aldehyde content of normal and lathyritic soluble collagen. Lab. Invest., 18:124.

    Google Scholar 

  • Parish, W.E., 1964, The distribution of mast cells and the possible function of some of their pharmacological agents, in Biological Aspects of Occlusive Vascular Disease (D.G. Chalmers and G.A. Gresham, eds.) pp. 84–119, Cambridge University Press.

    Google Scholar 

  • Parker, F., 1958, An electronmicroscope study of coronary arteries. Amer. J. Anat., 103:247.

    Article  Google Scholar 

  • Parker, F., 1960, An electron microscopic study of experimental atherosclerosis. Amer. J Path., 36:19.

    Google Scholar 

  • Parker, F., Ormsby, J.W., Peterson, N.F., Odland, G.F., and Williams, R.H., 1966, In vitro studies of phospholipid synthesis in experimental atherosclerosis: possible role of myo-intimal cells. Circulat. Res., 19:700.

    Google Scholar 

  • Partridge, S.M., and Elsden, D.F., 1961, The chemistry of connective tissues. 7. Dissociation of the chondroitin sulphate-protein complex of cartilage with alkali. Biochem. J., 79:26.

    Google Scholar 

  • Partridge. S.M., 1966, Biosynthesis and nature of elastic structures. Fed. Proc., 25:pt. 1, 1023.

    Google Scholar 

  • Partridge. S.M., 1969, Elastin, biosynthesis and structure. Gerontologia, 15:85.

    Article  Google Scholar 

  • Partridge, S.M., Davis, H.F., and Adair, G.S., The chemistry of connective tissues: 6. The constitution of the condroitin sulphate-protein complex in cartilage. Biochem. J., 79:15.

    Google Scholar 

  • Parwaresch, M.R., and Petersen, A., 1969, The effect of histamine and atherogenic diet on the number of tissue mast cells of the rat. Virchows Arch. Abt. B., 4:137.

    Google Scholar 

  • Patek, P.R., De Mignard, V.A., and Bernick, S., 1968, Changes in structure of coronary arteries. Arch. Path., 85:388.

    Google Scholar 

  • Paterson, J.C., 1936, Vascularization and haemorrhage of the intima of arteriosclerotic coronary arteries. Arch. Path., 22:313.

    Google Scholar 

  • Paterson, J.C., Mills, J., and Moffatt, T., 1957, Vascularization of early atherosclerotic plaques. Arch. Path., 64:129.

    Google Scholar 

  • Paterson, J.C., and Mills, J., 1958, Myocardial mast cell counts in coronary sclerosis. Arch. Path., 66:335.

    Google Scholar 

  • Patrick, A.D., and Lake, B.D., 1969, Deficiency of an acid lipase in Wolman’s disease. Nature (Lond.), 222:1067.

    Article  ADS  Google Scholar 

  • Paul, R.J., Bauer, M., Pease, W., 1979, Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes. Science, 206:414–1416.

    Article  Google Scholar 

  • Paule, W.J., 1963, Electronmicroscopy of the newborn rat aorta. J. Ultrastruct. Res., 8:219.

    Article  Google Scholar 

  • Paule, W.J., Zemplényi, T.K., Rounds, D.E., and Blankenhorn, D.H., 1976, Light-and electron-microscopic characteristics of arterial smooth muscle cell cultures subjected to hypoxia or carbon monoxide. Atherosclerosis, 25:111–123.

    Article  Google Scholar 

  • Paulson, S., Sylvan, B., Hirsch, C., and Senellman, O., 1951, Biophysical and physiological investigtions on cartilage and other mesenchymal tissues. III. The diffusion rate of various substances in normal bovine nucleus palposus. Biochem. Biophys. Acta. (Amst.), 7:207.

    Article  Google Scholar 

  • Payne, B.C., Kim, H., Pangalis, G.A., Rothman, A., Rappaport, H., 1980, A method for the ultrastructural demonstration of nonspecific esterase in human blood and lymphoid tissue. Histochem. J., 12:71–86.

    Article  Google Scholar 

  • Pearce, R.M., 1908, Occurrence of spontaneous arterial degeneration in the rabbit. J. Amer. Med. Assoc., 51:1056.

    Article  Google Scholar 

  • Pearl, F., and Friedman, M., 1964, Experimental coronary atherosclerosis in the dog. Arch. Path., 77:370.

    Google Scholar 

  • Pearse, A.G.E., 1968, Histochemistry — Theoretical and Applied, 3 rd edit., Vol. 1, Churchill, London.

    Google Scholar 

  • Pearse, A.G.E., 1972, Histochemistry — Theoretical and Applied, 3 rd edit., Vol. 2, Churchill, London.

    Google Scholar 

  • Pearse, A.G.E., Ewen, S.W.B., and Polak, J.M., 1972, The genesis of apudamyloid in endocrine polypeptide tumours: histochemical distinction from immunamyloid. Virchows Arch. Abt. B., 10:93.

    Google Scholar 

  • Pearson, T.A., Wang, A., Solez, K., and Heptinstall, R.H., 1975, Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Amer. J. Pathol., 81:379–387.

    Google Scholar 

  • Pearson, T.A., Dillman, J.M., Solez, K., and Heptinstall, R.H., 1978, Clonal characteristics in layers of human atherosclerotic plaques. Amer. J. Path., 93:93–102.

    Google Scholar 

  • Pearson, T.A., Dillman, J., Solez, K., and Heptinstall, R.H., 1979, Monoclonal characteristics of organizing arterial thrombi: Significance in the origin and growth of human atherosclerotic plaques. Lancet, i:7–11.

    Article  Google Scholar 

  • Pease, D.C., and Molinari, Sandra, 1960, Electronmicroscopy of muscular arteries; pial vessels of the cat and monkey. J. Ultrastruct. Res., 3:447.

    Article  Google Scholar 

  • Peng, S-K., Taylor, C.B., Tham, P., Werthessen, N.T., and Makkleson, B., 1978, Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells. Arch. Pathol., 102:57.

    Google Scholar 

  • Pepler, W.J., and Brandt, F.A., 1954, A contribution to the nature of the elastolytic enzyme and the structure of elastin. Brit. J. Exp. Path., 35:41.

    Google Scholar 

  • Pepler, W.J., and Meyer, B.J., 1961, Mast cells in the coronary arteries. Arch. Path., 71:209.

    Google Scholar 

  • Peters, T.J., Takano, T., and De Duve, C., 1973, Subcellular fractionation studies on the cells isolated from normal atherosclerotic aorta, in Atherogenesis: Initiating Factors, CIBA Foundation Symposium, No. 12 (N.S) p. 197.

    Google Scholar 

  • Peters, R.A., 1978, Cholesterol hydroperoxide — a potential cardiac hazard. J. Roy. Soc. Med., 71:459–60.

    Google Scholar 

  • Petersen, J.E., and Hirst, A.E., 1951, Studies on the retention of dietary cholesterol and atheroma in chickens. Circulation, 3:116.

    Google Scholar 

  • Peterson, J.W., and Paul, R.J., 1974, Aerobic glycolysis in vascular smooth muscle. B.B.A., 357:167–176.

    Google Scholar 

  • Petroff, J.R., 1922–1923, Über die Vitalfärbund der Gefäfswandun-gen. Beitr. Path. Anat. Physiol., 71:115.

    Google Scholar 

  • Picard, J., Hermelin, B., and Breton, M., 1973, Modifications des protéoglycanes de la paroi artérielle au cours de vieillissement. Paroi Artérielle, 1:159.

    Google Scholar 

  • Piez, K.A., 1968, Cross-linking of collagen and elastin. Ann. Rev. Biochem., 37:547.

    Article  Google Scholar 

  • Pinkus, G.S., Hargreaves, H.K., McLeod, J.A., Nadler, L.M., Rosenthal, D.S., and Said, J.W., 1979, α Naphthylacetate esterase activity — a cytochemical maker. Amer. J. Path., 97:17–41.

    Google Scholar 

  • Pinnell, S.R., and Martin, G.R., 1968, The cross-linking of collagen and elastin: Enzymatic conversion of lysine in peptide linkage to α-aminoadipic-δ-semialdehyde (allysine) by an extract from bone. Proc. Nat. Acad. Sci. U.S.A., 61:708

    Article  ADS  Google Scholar 

  • Pinnell, S.R., Martin, G.R., and Miller, E.J., 1968, Desmosine biosynthesis: nature of inhibition of D-penicillamine. Science, 161:475.

    Article  ADS  Google Scholar 

  • Pizzolato, P., and Lillie, R.D., 1969, Schiff and haematoxylin reactions of mammalian arterial elastica. Arch. Path., 88:581.

    Google Scholar 

  • Pomerance, A., 1958, Peri-arterial mast cells in coronary atheroma and thrombosis. J. Path. Bact., 76:55.

    Article  Google Scholar 

  • Pomerance, Ariela, 1966, The pathology of senile cardiac amyloidosis. J. Path. Bact., 91:357.

    Article  Google Scholar 

  • Poole, J.C.F., and Florey, H.W., 1958, Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits. J. Path. Bact., 75:245.

    Article  Google Scholar 

  • Pouchlev, A., Youroukova, Z., and Kiprov., D., 1966, A study of changes in the number of mast cells in the human arterial wall during the stages of development of atherosclerosis. J. Atheroscler. Res., 6:342.

    Article  Google Scholar 

  • Post, R.L., and Sen, A.K., 1965, An enzymatic mechanism of active sodium and potassium transport. J. Histochem. Cytochem., 13:105.

    Article  Google Scholar 

  • Pras, M., Nevo, Z., Schubert, M., Rotman, J., and Metalon, R., 1971, The significance of mucopolysaccharides in amyloid. J. Histochem. Cytochem., 19:443.

    Article  Google Scholar 

  • Puchtler, H., Chandler, A.B., and Sweat, F., 1961, Demonstration of fibrin in tissue sections by the rosindole method. J. Histochem. Cytochem., 9:340.

    Article  Google Scholar 

  • Puchtler, H., Sweat, Faye, and Levine, M., 1962, On the binding of Congo red by amyloid. J. Histochem. Cytochem., 10:355.

    Article  Google Scholar 

  • Puchtler, H., Sweat, F., and Kuhns, J.G., 1964, On the binding of direct cotton dyes by amyloid. J. Histochem. Cytochem., 12:900.

    Article  Google Scholar 

  • Puchtler, H., and Sweat, F., 1965, Congo Red as a stain for fluorescence microscopy of amyloid. J. Histochem. Cytochem., 13:693.

    Article  Google Scholar 

  • Puchtler, H., Waldrop, F.S., and Valentine, L.S., 1973, Fluorescence microscopic distinction between elastin and collagen. Histochemie, 35:17.

    Article  Google Scholar 

  • Pugh, Doreen, and Walker, P.G., 1961a, Histochemical localization of β-glucuronidase and N-acetyl-β-glucosaminidase. J. Histochem. Cytochem., 9:105.

    Article  Google Scholar 

  • Pugh, D., and Walker, P.G., 1961b, The localization of N-acetyl-β-glucosaminidase in tissue. J. Histochem. Cytochem., 9:242.

    Article  Google Scholar 

  • Rabaud, M., Crockett, R., Razaka, G., Grenie, D., Dallocchio, M., and Bricaud, H., 1973, Étude expérimentale des isozymes de la L-lactate oxydo-réductase de la paroi aortique normale et pathologique du lapin. Paroi Artérielle, 1:65.

    Google Scholar 

  • Radhakrishnamurthy, B., Eggen, D.A., Kokatnur, M., Jirge, S., Strong, J.P., and Berenson, G.S., 1975, Composition of connective tissue in aortas from rhesus monkeys during regression of diet-induced fatty streaks. Lab. Invest., 33:136–140.

    Google Scholar 

  • Radhakrishnamurthy, B., Ruiz, H.A., Dalferes, E.R., Friedman, M., Seethanathan, P., Berenson, G.S., 1978, Connective tissue composition of aortas from non human primates — a comparative study. Atherosclerosis, 29:25–38.

    Article  Google Scholar 

  • Radhakrishnamurthy, B., Ruiz, H.A., Dalferes, E.R., Vesselinovitch, D., Wissler, R.W., and Berenson, G.S., 1979, The effect of various dietary regimens and cholestyramine on aortic glyco-saminoglycans during regression of atherosclerotic lesions in rhesus monkeys. Atherosclerosis, 33:17–28.

    Article  Google Scholar 

  • Raekallio, J., 1958, Histochemical studies on idiopathic medio-necrosis of the aorta. Arch. Path., 66:733.

    Google Scholar 

  • Raekallio, J., 1961, Histochemical studies on vital and post-mortem skin wounds. Ann. Med. Exp. Biol. Fenn., 39:Suppl. 6.

    Google Scholar 

  • Rambourg, A., and Leblond, C.P., 1967, Staining of basement membranes and associated structures of the periodic acid-Schiff and periodic acid-silver methanamine techniques. J. Ultrastruct. Res., 20:306.

    Article  Google Scholar 

  • Randerath, E., Diezel, P.B., and Pfleiderer, A., Jr., 1960, Histo-chemische Befunde an den Glomerulumveränderungem bei der diabetischen Glomerulosklerose. Archo. “De Vecchi,” 31:385.

    Google Scholar 

  • Reidy, M.A., and Bowyer, D.B., 1978, Distortion of endothelial repair. The effect of hypercholesterolemia on regeneration of aortic endothelium following injury by endotoxin. Atherosclerosis, 29:459–466.

    Article  Google Scholar 

  • Reis, J.L., 1950, Studies on 5-nucleotidase and its distribution in human tissues. Biochem. J., 46:21.

    Google Scholar 

  • Reis, J.L., 1951, The pecificity of phosphomonesterases in human tissues. Biochem. J., 48:548.

    Google Scholar 

  • Rice, W.G., and Mitchener, J., 1961, Histochemical evidence of 5-hydroxytryptamine in a dog mast cell tumour. Nature (Lond.), 189:767.

    Article  ADS  Google Scholar 

  • Robert, B., Szigeti, M., Robert, L., Legrand, Y., Pignaud, G., and Caen, J., 1970, Release of elastolytic activity from blood platelets. Nature (Lond.), 227:1248.

    Article  ADS  Google Scholar 

  • Robert, B., Szigeti, M., Derouette, J.-C., Robert, L., Bouissou, H., and Fabre, M.-T., 1971, Studies on the nature of the “micro fibrillar” component of elastic fibers. European J. Biochem., 21:507.

    Article  Google Scholar 

  • Robert, L., 1980, The elastic element in the arterial wall: biosynthesis and degradation. In Atherosclerosis V (ed. A.M. Gotto, L.C. Smith, and B. Allen), Springer, Berlin, p. 136.

    Chapter  Google Scholar 

  • Robertson, A.L., 1968, Oxygen requirements of the human arterial intima in atherogenesis. Progr. Biochem. Pharmacol., 4:305.

    Google Scholar 

  • Robertson, A.L., Jr., and Khairallah, P.H., 1973, Arterial endothelial permeability and vascular disease. The “trap-door” effect. Exp. Molec. Path., 18:241.

    Article  Google Scholar 

  • Robertson, H.F., 1929, Vascularization of the thoracic aorta. Arch. Path., 8:881.

    Google Scholar 

  • Robins, S.P., and Bailey, A.J., 1975, The chemistry of the collagen cross-links. The mechanism of stabilization of the reducible intermediate cross-links. Biochem. J., 149:381.

    Google Scholar 

  • Rodgers, J.C., Puchtler, H., and Gropp, S., 1967, Transition from elastin to collagen in internal elastic membrane. Arch. Path., 83:557.

    Google Scholar 

  • Rodriquez, F.L., and Robbins, S.L., 1959, Capacity of human coronary arteries. A postmortem study. Circulation, 19:570.

    Google Scholar 

  • Rojkinod, M., Gutierrez, A.M., Zeichner, M., and Lent, R.W., 1969, The nature of the intramolecular cross-link in collagen. Biochem. Biophys. Res. Commun., 36:350.

    Article  Google Scholar 

  • Romanul, F.C.A., and Bannister, R.G., 1962a, Localized areas of high alkaline phosphatase activity in endothelium of arteries. Nature (Lond.), 195:611.

    Article  ADS  Google Scholar 

  • Romanul, F.C.A., and Bannister, R.G., 1962b, Localized areas of high alkaline phosphatase activity in the terminal arterial tree. J. Cell Biol., 15:73.

    Article  Google Scholar 

  • Rose, G., Prineas, R.J., and Mitchell, J.R.A., 1967, Myocardial infarction and the intrinsic calibre of coronary arteries. Brit. Heart J., 29:248.

    Article  Google Scholar 

  • Rosen, L.A., and Hillis, T.M., 1973, Endothelial succinate utilization in atherosclerotic rabbits. Atherosclerosis, 17:297.

    Article  Google Scholar 

  • Rosenberg, P., and Dettbarn, W.-D., 1965, Cholinesterase activity of rabbit aorta. Life Sciences, 4:567.

    Article  Google Scholar 

  • Rosenthal, C.J., and Franklin, E.C., 1975, Variation with age and disease of an amyloid A protein-related serum component. J. Clin. Invest., 55:746–753.

    Article  Google Scholar 

  • Ross, R., and Bornstein, P., 1969, The elastic fiber. I. Separation and partial characterization of its macromolecular components. J. Cell Biol., 40:366.

    Article  Google Scholar 

  • Ross, R., 1971, The smooth muscle. II. Growth of smooth muscle in culture and formation of elastic fibers. J. Cell Biol., 50:172.

    Article  Google Scholar 

  • Ross, R., and Klebanoff, S.J., 1971, The smooth muscle cell I. In vivo synthesis of connective tissue proteins. J. Cell Biol., 50:159.

    Article  Google Scholar 

  • Ross, R., 1973, The elastic fiber: a review. J. Histochem. Cytochem., 21:199.

    Article  Google Scholar 

  • Ross, R., 1975, Smooth muscle structure. Adv. Exp. Med. and Biol., 57:64–77.

    Google Scholar 

  • Ross, R., and Vogel A., 1978, The platelet derived growth factor. Cell, 14:203–210.

    Article  Google Scholar 

  • Rostgaard, J., and Barrnett, R.J., 1965, Nucleoside phosphatase activity of smooth muscle and other structures of tunica muscularis of small intestine. J. Histochem. Cytochem., 13:34.

    Google Scholar 

  • Rottino, A., 1929, Medial degeneration of the aorta as seen in twelve cases of dissecting aneurysm. Arch. Path., 28:1.

    Google Scholar 

  • Rottino, A., 1939, Medial degeneration of the arota: a study of two hundred and ten routine autopsy specimens by a serial block method. Arch. Path., 28:377.

    Google Scholar 

  • Rounds, D.E., Booher, J., and Guerrero, R.R., 1976, Consideration of atherosclerotic plaques as benign neoplasma. Atherosclerosis, 25:183–189.

    Article  Google Scholar 

  • Rubinstein, L.G., Maier, N., and Haemovici, H., 1968, Slide histochemistry of enzyme activity in normal and atherosclerotic canine aorta. Ann. N.Y. Acad. Sci., 149:673.

    Article  ADS  Google Scholar 

  • Rucker, R.B., Parker, H.E., and Rogler, J.C., 1969, The effects of copper on collagen cross-linking. Biochem. Biophys. Res. Commun., 34:28.

    Article  Google Scholar 

  • Rucker, R.B., and O’Dell, B.L., 1970, Inhibition of elastin cross-linking by iproniazid and its counteraction by pyrodoxal phosphate. Biochim. Biophys. Acta., 222:527.

    Article  Google Scholar 

  • Sacks, N., 1954, Chemical properties of elastic fibres. S. Afr. J. Med. Sci., 19:165.

    Google Scholar 

  • Samarasinghe, D.D., 1965, The innervation of the cerebral arteries in the rat: an electron microscope study. J. Anat. (Lond.), 99:815.

    Google Scholar 

  • Sandler, M., and Bourne, G.H., 1960a, Some histochemical observations on the human aortic wall in atherosclerosis. Circulat. Res., 8:1274.

    Google Scholar 

  • Sandler, M., and Bourne, G.H., 1960b, Histochemical localization of enzymes dephosphorylating ATP and AMP in animal aortae. J. Gerontol., 15:32.

    Google Scholar 

  • Sandler, M., and Bourne, G.H., 1963, Histochemistry of atherosclerosis, in Atherosclerosis and Its Origin (M. Sandler and G.H. Bourne, eds.) pp. 515–532, Academic Press, New York.

    Google Scholar 

  • Sanerkin, N.G., 1971, Vascular lesions of malignant hypertension. J. Path., 103:177.

    Article  Google Scholar 

  • Santerre, R.F., Nicolosi, R.J., and Smoth, S.C., 1974, Respiratory control in preatherosclerotic susceptible and resistant pigeon aortas. Exp. Molec. Path., 20:397.

    Article  Google Scholar 

  • Sarma, J.S.M., Tschurtschenthaler, G.V., and Bing, R.J., 1978, Effect of high density lipoproteins on the cholesterol uptake of isolated pig coronary arteries. Artery, 4:214–223.

    Google Scholar 

  • Saudek, C.D., Adams, C.W.M., and Bayliss, O.B., 1966, The quantitative histochemistry and cytochemistry of lactic dehydrogenase and NADH2-tetrazolium reductase in human aortic wall. J. Path. Bact., 92:265.

    Article  Google Scholar 

  • Saxl, H., 1957, The physiological significance of the reaction between elastin and elastomucase in relation to the production of “clearing factor.” Gerontologia, 1:142.

    Article  Google Scholar 

  • Saxl, H., 1961, Studies of elastin lipoprotein of human and chicken aorta. J. Roy. Micros. Soc., 79:319.

    Article  Google Scholar 

  • Saxl, H., 1962, Studies of lipid reactions in the connective tissue of the vascular wall. Ann. Histochim., 6:347.

    Google Scholar 

  • Scarpelli, D.G., and Kanczak, N.M., 1965, Ultrastructural cytochemistry: principles, limitations and applications, in International Review of Experimental Pathology. (G.W. Richter and M.A. Epstein, eds.) Vol. 4, pp. 55–126, Academic Press, New York.

    Google Scholar 

  • Schaffner, T., Einer, V.M., Bauer, M., and Wissler, R.W., 1978, Acid lipase: a histochemical and biochemical study using Triton X100-naphthyl palmitate micelles. J. Histochem. Cytochem., 26:696–712.

    Article  Google Scholar 

  • Schaffner, T., Taylor, K., Zarins, C., Glagov, S., and Wissler, R.W., 1980, Foam cells with macrophage properties: Characterization in experimental and human atheromatous lesions. Athero-genesis 4: Abstracts of 2nd International Atherosclerosis Conference, Vienna, p. 138.

    Google Scholar 

  • Schallock, G., 1962, On the morphology of atherosclerosis. J. Atheroscler. Res., 2:25.

    Article  Google Scholar 

  • Schaper, J., König, R., Franz, D., and Schaper, W., 1976, The endothelial surface of growing coronary collateral arteries. Intimal margination and diapedesis of monocytes. Virchows Arch., Abt. A, 370:193.

    Google Scholar 

  • Scheinberg, M.A., and Cathcart, E.S., 1978, New concepts in the pathogenesis of primary and secondary amyloid disease. Clin. Exp. Immunol., 33:185–190.

    Google Scholar 

  • Schenk, E.A., and El Badawi, A., 1968, Dual innervation of arteries and arterioles. A histochemical study. Z. Zellforsch., 91:170.

    Article  Google Scholar 

  • Schiller, Sara, 1966, Connective and supporting tissues: mucopolysaccharides of connective tissues. Ann. Rev. Physiol., 28:137.

    Article  Google Scholar 

  • Schlichter, J.G., 1946, Studies on the vascularization of the aorta. I. The vascularization of the aorta in the normal dog. Amer. Heart J., 32:710.

    Article  Google Scholar 

  • Schlichter, J., and Harris, R., 1949, The vascularization of the aorta. II. A comparative study of the aortic vascularization of several species in health and disease. Amer. J. Med. Sci., 218:610.

    Article  Google Scholar 

  • Schlief, H., Schmidt, C.G., and Hillenbrand, H.J., 1954, Untersuchungen über Arteriosklerose und Endangitis Obliterans. IV. Die Aktivat der Phosphomonoesterasen. Z. Ges. Exp. Med., 122:497.

    Article  Google Scholar 

  • Schorah, C.J., Lovell, D., and Curran, R.C., 1968, Arterial acid mucopolysaccharide concentrations: their correlation with age and intimal hyperplasia. Brit. J. Exp. Path., 49:574.

    Google Scholar 

  • Schütte, H.E., 1968, Changes in the vasa vasorum of the atherosclerotic aortic wall. Angiologica, 5:210.

    Google Scholar 

  • Schwartz, P., 1970, Amyloidosis: cause and manifestation of senile degeneration, Thomas, Springfield, Ill.

    Google Scholar 

  • Schwartz, S.M., and Benditt, E.P., 1972, Studies on aortic intima. I. Structure and permeability of rat thoracic aortic intima. Amer. J. Path., 66:241.

    Google Scholar 

  • Scott, D.M., Harwood, R., Grant, M.E., and Jackson, M.S., 1977, Characterization of the major collagen species present in porcine aortae and the synthesis of their precursors by smooth muscle cells in culture. Conn. Tissue Res., 5:7.

    Article  Google Scholar 

  • Scott, J.E., and Dorling, J., 1965, Differential staining of acid glycosaminoglycans (mucopolysaccharides) by Alcian blue in salt solutions. Histochimie, 5:221.

    Article  Google Scholar 

  • Scott, P.J., and Hurley, P.J., 1970, The distribution of radio iodinated serum albumin and low-density lipoprotein in tissues and the arterial wall. Atherosclerosis, 11:77.

    Article  Google Scholar 

  • Scott, T.G., 1965, The specificity of 5’-nucleotidase in the brain of the mouse. J. Histochem. Cytochem., 13:657.

    Article  Google Scholar 

  • Seethanathan, P., and Kurup, P.A., 1971, Changes in tissue glycosaminoglycans in rats fed a hypercholesterolaemic diet. Atherosclerosis, 14:65.

    Article  Google Scholar 

  • Sharpe, D.N., Scott, P.J., Flint, M.H., and Donald, J., 1980, Arterial connective tissue changes and distribution of 125I-labelled low density lipoprotein in hypertensive pigs. Atherosclerosis, 35:393–411.

    Article  Google Scholar 

  • Shimamoto, T., 1963, The relationship of oedematous reaction in arteries to atherosclerosis and thrombosis. J. Atheroscler. Res., 3:87

    Article  Google Scholar 

  • Shimamoto, T., Sasaki, T., and Sunaga, T., 1967, Species difference in fine structure of capillaries in vasa vasorum of aortas and its reference to atherosclerosis. Proc. Japan Acad., 43:1025.

    Google Scholar 

  • Shimamoto, T., 1969, Visualization of the transendothelial passage through intercellular junctions and discovery of endothelial folds and intercellular bridges of vascular endothelium, in Atherogenesis (T. Shimamoto and F. Numano, eds.) p. 5, Excerpta Medica Foundation, Amsterdam.

    Google Scholar 

  • Shimamoto, T., Kobayishi, M., and Numano, F., 1972, Infiltration of γ-globulin, fibrinogen and β-lipoprotein into blood vessel wall by atherogenic stress visualized by immunofluorescence. Proc. Japan Acad., 48:336.

    Google Scholar 

  • Shio, H., Farquhar, M.G., and De Duve, C., 1974, Cytochemical localization of acid phosphatase and catalase in smooth muscle cells and foam cells from rabbit atheromatous aorta. Amer. J. Path., 76:1.

    Google Scholar 

  • Shio, H., Haley, N.J., and Fowler, S., 1979, Characterization of lipid laden aortic cells from cholesterol-fed rabbits. III Intracellular localization of cholesterol and cholesteryl ester. Lab. Invest., 41:160–167.

    Google Scholar 

  • Short, D.S., and Thomson, A.D., 1959, The arteries of the small intestine in systemic hypertension. J. Path. Bact., 78:321.

    Article  Google Scholar 

  • Short, D.S., 1966a, The vascular fault in chronic hypertension. Lancet, i:1302.

    Article  Google Scholar 

  • Short, D.S., 1966b, Morphology of the intestinal arterioles in chronic human hypertension. Brit. Heart J., 28:184.

    Article  Google Scholar 

  • Siegel, R.C., Pinnell, S.R., and Martin, G.R., 1970, Cross-linking of collagen and elastin. Properties of lysyl oxidase. Biochemistry, 9:4486.

    Article  Google Scholar 

  • Simpson, CF., and Harms, R.H., 1964, Pathology of the aorta of chicks fed a copper-deficient diet. Exp. Molec. Path., 3:390.

    Article  Google Scholar 

  • Sinapius, D., 1968, Die Entstehung subendothelioler Lipophagen-herde bei Coronarsklerose. Virchows Arch., Abt. A, 345:169.

    Article  Google Scholar 

  • Sinapius, D., 1969, Mediaverfettung bein Atherosklerose. Verh. dt. Ges. Path., 53:456.

    Google Scholar 

  • Sinzinger, H., Silberbauer, K., and Auerswald, W., 1980a, Does prostacyclin PGl2 regulate human arterial intima smooth muscle cell proliferation in early atherogenesis? Blood Vessels, 17:58.

    Google Scholar 

  • Sinzinger, H., Silberbauer, K., and Auerswald, W., 1980b, Prostacyclin production by vascular smooth muscle and endothelial cells. In Atherosclerosis V (ed. A.M. Gotto, J.C Smith, and B. Allen), Springer, Berlin, pp. 140–143.

    Chapter  Google Scholar 

  • Sirek, O.V., Schiller, S., and Dorfman, A., 1964, Acid mucopolysaccharides in aortic tissues of the dog. Biochim. Biophys. Acta., 83:148.

    Google Scholar 

  • Skou, J.C., 1960, Further investigations on a Mg++ and Na++ activated ATPase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane. Biochim. Biophys. Acta., 42:6.

    Article  Google Scholar 

  • Small, D.M., 1980, Summary of concepts concerning the arterial wall and its atherosclerotic lesions. In Atherosclerosis V (ed. by A.M. Gotto, L.C. Smith, and B. Allen), Springer, Berlin, P. 520.

    Chapter  Google Scholar 

  • Smith, E.B., 1965, The influence of age and atherosclerosis on the chemistry of aortic intima. J. Atheroscler. Res., 5:241.

    Article  Google Scholar 

  • Smith, E.B., and Slater, R.S., 1970, The chemical and immunological assay of low-density lipoproteins extracted from human aortic intima. Atherosclerosis, 11:417.

    Article  Google Scholar 

  • Smith, E.B., and Slater, R.S., 1972a, Relationship between low density lipoprotein in aortic intima and serum-lipid levels. Lancet, i:463.

    Article  Google Scholar 

  • Smith, E.B., and Slater, R.S., 1972b, The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. Part 1 (The lipids in the isolated fractions). Atherosclerosis, 15:37.

    Article  Google Scholar 

  • Smith, E.B., 1973, Lipids and low density lipoproteins in intima in relation to its morphological characteristics, in Atherogenesis: Initiating factors, CIBA Foundation Symposium, 12 (N.S) P. 39.

    Google Scholar 

  • Smith, E.B., Slater, R.S., and Hunter, J.A., 1973, Quantitative studies on fibrinogen and low density lipoprotein in human aortic intima. Atherosclerosis, 18:479.

    Article  Google Scholar 

  • Smith, E.B., Massie, I.B., and Alexander, K.M., 1976, The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin. Atherosclerosis, 25:71–84.

    Article  Google Scholar 

  • Smith, E.B., 1980, Biochemical studies on permeability and the interaction between blood constitutents and arterial components in atherosclerosis. In Atherosclerosis V (ed. by A.M. Gotto, L.C. Smith, and B. Allen), Springer, Berlin, p. 121.

    Chapter  Google Scholar 

  • Smith, L.L., Van Lier, J.E., 1970, Sterol metabolism: part 9: 26-hydroxycholesterol levels in the human aorta. Atherosclerosis, 12:1–14.

    Article  MATH  Google Scholar 

  • Smith, L.L., Pandya, N.L., 1973, Sterol metabolism: part 18: On the uniqueness of the occurrence of 26-hydroxycholesterol in the human aorta. Atherosclerosis, 17:21–30.

    Article  Google Scholar 

  • Smith, L.L., Smart, V.B., and Ansari, G.A.S., 1979, Mutagenic cholesterol preparations. Mutation Res., 68:23–30.

    Article  Google Scholar 

  • Sober, H.A., 1970, Handbook of Biochemistry, 2nd edition, Chemical Rubber Co., Cleveland, Ohio.

    Google Scholar 

  • Somer, J.B., and Schwartz, C.J., 1971, Focal 3H-cholesterol uptake in the pig aorta. Atherosclerosis, 13:293.

    Article  Google Scholar 

  • Somer, J.B., and Schwartz, C.J., 1972, Focal 3H-cholesterol uptake in the pig aorta. Part 2, Distribution of 3H-cholesterol across the aortic wall in areas of high and low uptake in vivo. Atherosclerosis, 16:377.

    Article  Google Scholar 

  • Spector, M., 1969, Atherosclerotic plaque: X-ray diffraction investigation. Science, 165:711.

    Article  ADS  Google Scholar 

  • Spiro, D., Lattes, R.G., and Wiener, J., 1965, The cellular pathology of experimental hypertension. I. Hyperplastic arterio-larsclerosis. Amer. J. Path., 47:19.

    Google Scholar 

  • Srinivasan, S.R., Dolan, P., Radhakrishnamurthy, R., and Berenson, G.S., 1972, Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aortas. Atherosclerosis, 16:95.

    Article  Google Scholar 

  • Stary, H.C., 1966, Disease of small blood vessels in diabetes mellitus. Amer. J. Med. Sci., 252:357.

    Article  Google Scholar 

  • Stary, H.C., and McMillan, G.C., 1970, Kinetics of cellular proliferation in experimental atherosclerosis. Arch. Path., 89:173.

    Google Scholar 

  • Stary, H.C., Strong, J.P., and Eggen, D.A., 1980, Differences in the degradation rate of intracellular lipid droplets in the intimal smooth muscle cells and macrophages of regressing atherosclerotic lesions of Primates. In Atherosclerosis V, (ed. by A.M. Gotto, L.C. Smith, and B. Allen), Springer, Berlin, p. 753.

    Chapter  Google Scholar 

  • St. Clair, R.W., Clarkson, T.B., and Lofland, H.B., 1972, Effects of regression of atherosclerotic lesions on the content and esterification of cholesterol by cell-free preparations of pigeon aorta. Circulat. Res., 31:664.

    Google Scholar 

  • Stehbens, W.E., 1964, Vascular changes in chronic peptic ulcer. Arch. Path., 78:584.

    Google Scholar 

  • Stein, A.A., and Harris, J., 1964, Histochemical enzyme distribution in human arteries. Surgery, 56:413.

    Google Scholar 

  • Stein, O., Sanger, L., Zajicek, G., and Stein, Y., 1973, Acid phosphatase in aortic smooth muscle cells studies by electron microscopic cytochemistry. Paroi Arterielle, 1:187.

    Google Scholar 

  • Stein, O., Vanderhoek, J., and Stein, Y., 1976, Cholesterol content and sterol synthesis in human skin fibroblasts and rat aortic smooth muscle cells exposed to lipoprotein-depleted serum and high density apolipoprotein/phospholipid mixtures. Biochim. Biophys. Acta., 431:347.

    Google Scholar 

  • Stein, Y., Stein, O., and Shapiro, B., 1963, Enzymic pathways of glyceride and phospholipid synthesis in aortic homogenates. Biochim. Biophys. Acta., 70:33.

    Article  Google Scholar 

  • Stein, Y., and Stein, O., 1973, Lipid synthesis and degradation and lipoprotein transport in mammalian aorta, in Atherogenesis: Initiating factors, CIBA Foundation Symposium 12 (N.S) p. 165.

    Google Scholar 

  • Stein, Y., Glangeaud, M.C., Fainaru, M., and Stein, O., 1975, The removal of cholesterol ester from aortic smooth muscle cells in culture and Lanschütz ascites cells by fractions of high density lipoprotein. Biochim. Biophys. Acta., 380:106.

    Google Scholar 

  • Stender, S., 1976, Turnover of cholesterol in aorta of rabbits previously fed a cholesterol enriched diet. Atherosclerosis, 23:275.

    Article  Google Scholar 

  • Still, W.J.S., and Dennison, S., 1974, The arterial endothelium of the hypertensive rat. Arch. Path., 97:337.

    Google Scholar 

  • Strebel, R.F., and Wagner, B.M., 1969, Experimental tissue calcification. Arch. Path., 87:93.

    Google Scholar 

  • Strong, J.P., Stary, H.C., and Eggen, D.A., 1977, Evolution and regression of aortic fatty streaks in rhesus monkeys. In Atherosclerosis (G.W. Manning and M.D. Haust, eds.) Plenum Press, New York, p. 603.

    Google Scholar 

  • Sunaga, T., Sasaki, T., and Shimamoto, T., 1967, Fine structure of capillary in atheromatous lesions in man and rabbit. Proc. Japan Acad., 43:1031.

    Google Scholar 

  • Sundberg, M., 1955, On the mast cells in the human vascular wall. Acta. Path. Scand. Suppl., 107.

    Google Scholar 

  • Suter, Elsi R., and Majno, G., 1965, Passage of lipid across vascular endothelium in new-born rats. An electron microscope study. J. Cell Biol., 27:163.

    Article  Google Scholar 

  • Swanson, M.A., 1948, Studies of the structure of polysaccharides. IV. Relation of the iodine color to the structure. J. Biol. Chem., 172:825.

    Google Scholar 

  • Sweetman, F., and Ornstein, L., 1974, Electrophoresis of elastase-like esterases from human neutrophils. J. Histochem. Cytochem., 22:327.

    Article  Google Scholar 

  • Symbas, P.N., Baldwin, B.J., Silverman, M.E., and Galambos, J.T., 1970, Marian’s syndrome with aneurysm of ascending aorta and aortic regurgitation. Surgical treatment and new histochemical observations. Amer. J. Cardiol., 25:483.

    Article  Google Scholar 

  • Symmers, W. St. C., 1956, Primary amyloidosis: a review. J. Clin. Path., 9:187.

    Article  Google Scholar 

  • Takeuchi, T., and Glenner, G.G., 1961, Histochemical demonstration of uridine diphosphate glucose-glycogen transferase in animal tissues. J. Histochem. Cytochem., 9:304.

    Article  Google Scholar 

  • Tammi, M., Seppälä, P.O., Lehtonen, A., and Möttönen, M., 1978, Connective tissue components in normal and atherosclerotic human coronary arteries. Atherosclerosis, 29:191–194.

    Article  Google Scholar 

  • Tanzer, M.L., 1965, Experimental lathyrism, in International Review of Connective Tissue Research (D.A. Hall, ed.) Vol. 3, pp. 91–112, Academic Press, New York.

    Google Scholar 

  • Tanzer, M.L., and Mechanic G., 1970, Isolation of lysinonorleucine fron collagen. Biochem. Biophys. Res. Commun., 39:183.

    Article  Google Scholar 

  • Taylor, C.B., Peng, S-K., Werthessen, N.T., Tham, P., and Lee, K.T., 1979, Spontaneously occurring angiotoxic derivatives of cholesterol. Amer. J. Clin. Nutrit., 32:40–57.

    Google Scholar 

  • Taylor, H.E., 1953, The role of mucopolysaccharides in the pathogenesis of intimal fibrosis and atherosclerosis of the human aorta. Amer. J. Path., 29:871.

    Google Scholar 

  • Tedeschi, C.G., Wagner, B.M., and Pani, K.C., 1955, Studies in rheumatic fever. I. The clinical significance of the Aschoff body based on morphologic observations. Arch. Path., 60:408.

    Google Scholar 

  • Termine, J.D., Eanes, E.D., Ein, D., and Glenner, G.G., 1972, Infrared spectroscopy of human amyloid fibrils and immunoglobulin proteins. Biopolymers, 11:1103.

    Article  Google Scholar 

  • Thoma, R., 1883, Über die Abhängigkeit der Bindegewebsneubildung in der Arterienintima von den mechanischen Bendingungen des Blutumlaufes. Virchows Arch., 93:443.

    Article  Google Scholar 

  • Thomas, P.K., and Lascelles, R.G., 1966, The pathology of diabetic neuropathy. Quart. J. Med., 35:489.

    Google Scholar 

  • Thomas, W.A., Florentin, R.A., Reiner, J.M., Lee, W.M., and Lee, K.T., 1976, Alterations in population dynamics of arterial smooth muscle cells during atherogenesis: IV. Evidence for polyclonal origin of hypercholesterolemic diet-induced atherosclerotic lesions in young swine. Exp. Molec. Path., 24:244.

    Article  Google Scholar 

  • Thomas, W.A., Reiner, J.M., Janakidevi, K., Florentin, R.A., and Lee, K.T., 1979, Population dynamics of arterial cells during atherogenesis X. Study of monotypism in atherosclerotic lesions of black women heterozygans for glucose-6-phosphate dehydrogenase. Exp. Mol. Path., 31:367–386.

    Article  Google Scholar 

  • Thornhill, D.P., 1972, Elastin: locus and characteristics of chromophore and fluorophore. Connect. Tissue Res., 1:21.

    Article  Google Scholar 

  • Thompson, R.H.S., and Tickner, A., 1951, The occurrence and distribution of monoamine oxidase in blood vessels. J. Physiol. (Lond.), 115:34.

    Google Scholar 

  • Thompson, R.H.S., and Tickner, A., 1953, Cholinesterase activity of arteries. J. Physiol. (Lond.), 121:623.

    Google Scholar 

  • Todd, A.S., 1959, Histological localisation of fibrinolysin activator, J. Path. Bact., 78:281.

    Article  Google Scholar 

  • Toole, B.P., 1969, Solubility of collagen fibrils formed in vitro in the presence of sulphated acid mucopolysaccharide-protein. Nature (Lond.), 222:872.

    Article  ADS  Google Scholar 

  • Torack, R.M., and Barrnett, R.J., 1964, The fine structural localization of nucleoside phosphatase activity in the blood brain barrier. J. Neurophath. Exp. Neurol., 23:46.

    Article  Google Scholar 

  • Torack, R.M., 1965, Electron histochemistry of the nervous system, in Neurohistochemistry. (C.W.M. Adams, ed.) p. 161, Elsevier, Amsterdam.

    Google Scholar 

  • Tsuda, T., Ando, M., Shima, K., Sugimoto, M., Onizuka, O., and Tokuomi, H., 1979, Chronologic changes of activities of naphthol AS-D acetate esterase and other non-specific esterases in the mononuclear phagocytes of tuberculous lesions. Amer. J. Pathol., 97:235–246.

    Google Scholar 

  • Tucker, C.F., Catsulis, C., Strong, J.P., and Eggen, D.A., 1971, Regression of early cholesterol-induced aortic lesions in rhesus monkeys. Amer. J. Path., 65:493.

    Google Scholar 

  • Urist, M.R., Speer, D.P., Ibsen, K.J., and Strates, B.S., 1968, Calcium binding by chondroitin sulphate. Calc. Tissue Res., 2:253.

    Article  Google Scholar 

  • Van Zutphen, L.F.M., and Fox, R.K., 1977, Strain difference in response to dietary cholesterol by JAX rabbits: correlation with esterase patterns. Atherosclerosis, 28:435–446.

    Article  Google Scholar 

  • Vasquez, J.J., and Dixon, F.J., 1957, Immunohistochemical study of lesions in rheumatic fever, systemic lupus erythematosus and rheumatoid arthritis. Lab. Invest., 6:205.

    Google Scholar 

  • Vasquez, J.J., and Dixon, F.J., 1958, Immunohistochemical analysis of lesions associated with “fibrinoid change.” Arch. Path., 66:504.

    Google Scholar 

  • Vassar, P.S., and Culling, C.F.A., 1959, Fluorescent stains, with special reference to amyloid and connective tissues. Arch. Path., 68:487.

    Google Scholar 

  • Velican, C., and Velican, D., 1964, Histochemistry of human aortic intima and the problem of atherosclerosis. Fed. Proc., 23: T572.

    Google Scholar 

  • Velican, C., 1970, Studies on the age-related changes occurring in human cerebral arteries. Atherosclerosis, 11:509.

    Article  Google Scholar 

  • Velican, C., 1974, Macromolecular changes in atherosclerosis, in Handbuch der Histochemie. Vol. 8, part 2, Fischer, Stuttgart.

    Google Scholar 

  • Velican, C., and Velican, D., 1976, Intimal thickening in developing coronary arteries and its relevance to atherosclerotic involvement. Atherosclerosis, 23:345.

    Article  Google Scholar 

  • Velican, C., and Velican, D., 1978, Heterogeneity in the composition and aggregation patterns of coronary intima acid mucopolysaccharides (glycosaminoglycans). Atherosclerosis, 29:141–159.

    Article  Google Scholar 

  • Vekhoff, D., Jacotot, B., and Beaumont, J.L., 1975, Transferts de lipoprotéines sanguines dans la paroi arteriélle normale. Paroi Artérielle, 2:241.

    Google Scholar 

  • Veress, B., Kóczé, A., and Jellinek, H., 1969, Morphology of early large vessel lesions in experimental hypertension. Brit. J. Exp. Path., 50:600.

    Google Scholar 

  • Veress, B., Bálint, A., and Jellinek, H., 1972, Permeability of the aorta in hypercholesterolaemic rats. Acta. Morphol. Hung., 20:199.

    Google Scholar 

  • Verity, M.A., Bevan, J.A., and Ostrom, R.J., 1966, Pleurivesicular nerve endings in the pulmonary artery. Nature (Lond.), 211:537.

    Article  ADS  Google Scholar 

  • Verity, M.A., and Bevan, J.A., 1969, Membrane adenosine triphosphatase activity of vascular smooth muscle. Biochem. Pharmacol., 18:327.

    Article  Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Dzoga, K., Hughes, R.H., and Dubien, L., 1974, Regression of atherosclerosis in rabbits. Part 1 (Treatment with low-fat, hyperoxia and hypolipidemic agents). Atherosclerosis, 19:259.

    Article  Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Hughes, R., and Borensztajn, J., 1976, Reversal of advanced atherosclerosis in rhesus monkeys. Part 1 (Light microscopic studies). Atherosclerosis, 23:155.

    Article  Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Harris, L., and Lusk, L., 1980, The relationship between lipoprotein levels and xanthomas during progression and regression of atherosclerosis. Atherosclerosis, (in press).

    Google Scholar 

  • Vijaykumar, S.T., Leelamma, S., and Kurup, P.A., 1975, Changes in aortic glycosaminoglycans and lipoprotein lipase activity in rats with age and atheroma. Atherosclerosis (in press).

    Google Scholar 

  • Vincent, D., Coeur, P., and Magron, J., 1968, Biochemical investigations of experimental atheroma in the rabbit. Cholinesterases and arylesterases in the plasma and aortic wall. I. and II. Semaine des Hôspitaux Paris Pathologie et Biologie, 16:837.

    Google Scholar 

  • Virchow, R., 1855, Zur Cellulose-Frage. Arch. Path. Anat. (Virchow), 8:140.

    Article  Google Scholar 

  • Wagh, P.V., Roberts, B.I., White, H.J., and Read, R.C., 1973, Changes in the content of human aortic glycoproteins and acid mucopolysaccharides in atherosclerosis. Atherosclerosis, 18:83.

    Article  Google Scholar 

  • Wagner, B.M., 1957, Histochemical studies of fibrinoid substances and other abnormal tissue proteins. J. Mt. Sinai Hosp., 24:1323.

    Google Scholar 

  • Wagner, W.D., and Clarkson, T.B., 1973, Slowly miscible cholesterol pools in progressing and regressing atherosclerotic aortas. Proc. Soc. Exp. Biol. (N.Y.), 143:804.

    Google Scholar 

  • Walker, D.G., and Wirkschafter, Z.T., 1956, Histopathogenesis of aortic aneurysms in the lathyrus-fed rat. Arch. Path., 61:125.

    Google Scholar 

  • Walton, K.W., and Williamson, N., 1968, Histological immunofluorescent studies on the evolution of the human atherosclerotic plaque. J. Atheroscler. Res., 8:599.

    Article  Google Scholar 

  • Walton, K.W., 1973, The role of glycosaminoglycans and calcium in atherosclerosis, in Connective Tissue and Ageing, p. 21, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Walton, K.W., Thomas, C., and Dunkerley, D.J., 1973, The pathogenesis of xanthomata. J. Path., 109:271.

    Article  Google Scholar 

  • Walton, K.W., Dunkerley, D.J., Johnson, A.G., Khan, M.K., Morris, C., and Watts, R.B., 1976, Investigation by immunofluorescence of arterial lesions in rabbits on two different lipid supplements and treated with pyridinol carbamate. Atherosclerosis, 23:117.

    Article  Google Scholar 

  • Warren, B.A., 1964, Fibrinolytic activity of vascular endothelium. Brit. Med. Bull., 20:213.

    Google Scholar 

  • Warren, B.A., 1965, Fibrinolytic properties and electron microscopic features of rabbit ear chamber endothelium. Brit. J. Exp. Path., 46:607.

    Google Scholar 

  • Warren, B.A., and Khan, S., 1974, The ultrastructure of the lysis of fibrin by endothelium in vitro. Brit. J. Exp. Path., 55:138.

    Google Scholar 

  • Warren, B.A., and Khan, S., 1975, The scanning electron microscopy of the lysis of fibrin by endothelium. Br. J. Exp. Path., 56:340.

    Google Scholar 

  • Waterson, J.G., Hume, W.R., and De La Lande, I.S., 1970, The distribution of Cholinesterase in the rabbit ear artery. J. Histochem. Cytochem., 18:211.

    Article  Google Scholar 

  • Watson, W.C., 1961, Hypercholesterolaemia, coronary lipidosis and the tissue mast cell. Brit. J. Exp. Path., 42:15.

    Google Scholar 

  • Watts, H.F., 1963, Role of lipoproteins in the formation of atherosclerotic lesions, in Evolution of the Atherosclerotic Plaque (R.J. Jones, ed.) pp. 117–132, University of Chicago Press.

    Google Scholar 

  • Weber, G., and Tosi, P., 1971, Observations with the scanning electron microscope on the development of cholesterol aortic atherosclerosis in the guinea-pig. Virchows Arch. Abt. A, 353:325.

    Article  Google Scholar 

  • Weber, G., Fabbrini, P., and Resi, L., 1973, On the presence of a concanavalin-A reactive coat over the endothelial aortic surface and its modifications during early cholesterol athero-genesis in rabbits. Virchows Arch. Abt. A, 359:299.

    Article  Google Scholar 

  • Weber, G., Fabbrini, P., and Resi, L., 1974, Scanning and transmission electronmicroscopy observations on the surface lining of aortic intimal plaques in rabbits on a hypercholesterolic diet. Virchows Arch. Abt. A, 364:325.

    Google Scholar 

  • Weber, G., Fabbrini, P., Capaccioli, E., and Resi, L., 1975, Repair of early cholesterol-induced aortic lesions in rabbits after withdrawal from short term atherogenic diet. Atherosclerosis, 22:565–572.

    Article  Google Scholar 

  • Webster, W.S., Bishop, S.P., and Geer, J.C., 1974a, Experimental aortic intimal thickening. II. Endothelialization and permeability. Amer. J. Path., 76:265.

    Google Scholar 

  • Webster, W.S., Bishop, S.P., and Geer, J.C., 1974b, Experimental aortic intimal thickening. I. Morphology and source of intimal cells. Amer. J. Path., 76:245.

    Google Scholar 

  • Wegmann, R., and Fouquet, J.P., 1961, Quelques modifications histoenzymologiques accompagnant le début du dépôt de cholesterol dans l’aorte du lapin. Ann. Histochim., 6:61.

    Google Scholar 

  • Weissman, N., Shields, G.S., and Carnes, W.H., 1963, Cardiovascular studies on copper-deficient swine. IV. Content and solubility of the aortic elastin, collagen and hexosamine. J. Biol. Chem., 238:3115.

    Google Scholar 

  • Weller, R.O., Clark, R.A., and Oswald, W.B., 1968, Stages in the formation and metabolism of intracellular lipid droplets in atherosclerosis. An electronmicroscope study. J. Atheroscler. Res., 8:249–263.

    Article  Google Scholar 

  • Wexler, B.C., and Epstein, M.J., 1963, Blood coagulation in arteriosclerotic rats. Nature (Lond.), 197:159.

    Article  ADS  Google Scholar 

  • Wexler, B.C., 1964, Spontaneous arteriosclerosis in repeatedly bred male and female rats. J. Atheroscler. Res., 4:57.

    Article  Google Scholar 

  • Wexler, B.C., and Kittinger, G.W., 1965, Adrenocortical function in arteriosclerotic female breeder rats. J. Atheroscler. Res., 5:317.

    Article  Google Scholar 

  • Wexler, B.C., 1970, Arteriosclerosis of the pancreas and changes in the islets of Langerhans of repeatedly bred rats. Brit. J. Exp. Path., 51:107.

    Google Scholar 

  • Wexler, B.C., and Greenberg, B.P., 1974, Adrenal cortico-medullary function in arteriosclerotic (breeder) and non-arterio-sclerotic (virgin) rats. Atherosclerosis., 20:155.

    Article  Google Scholar 

  • Wicks, M.P., and Gardner, D.L., 1973, Microchemical determination of enzyme activities in the lathyritic chick embryo aorta. Brit. J. Exp. Path., 54:422.

    Google Scholar 

  • Wilens, S.L., 1947, The resorption of arterial atheromatous deposits in wasting disease. Amer. J. Path., 23:783.

    Google Scholar 

  • Wilens, S.L., 1951a, The nature of diffuse intimal thickening. Amer. J. Path., 27:825.

    Google Scholar 

  • Wilens, S.L., 1951b, Experimental production of lipid deposition in excised arteries. Science, 114:389.

    Article  ADS  Google Scholar 

  • Wilens, S.L., and McCluskey, R.T., 1954, The permeability of excised arteries and other tissues to serum lipid. Circulat. Res., 2:175.

    Google Scholar 

  • Wilens, S.L., 1959, Regression of traumatic cutaneous and aural lipid deposits in cholesterol fed rabbits. J. Path., 35:633.

    Google Scholar 

  • Williams, C.H., Gibbs, R.H., and Kamin, H., 1959, A microsomal TPNH-neotetrazolium diaphorase. Biochim. Biophys. Acta., 32:568.

    Article  Google Scholar 

  • Wilson, J., Adams, C.W.M., and Brander, W.L., 1978, The antiocclusive effect of coronary dilatation with age. Atherosclerosis, (in press).

    Google Scholar 

  • Wirtschafter, Z.T., 1957, Acid mucopolysaccharides in the histopathogenesis of aortic aneurysms in the lathyrus-fed rat. Arch. Path., 64:577.

    Google Scholar 

  • Wirtschafter, Z.T., and Bentley, J.P., 1965, Extractable collagen in the normal and aneurysmal aorta. Arch. Path., 79:635.

    Google Scholar 

  • Wissler, R.W. Ellert, M.L., Schroeder, M.A., and Cohen, L., 1954, Production of lipomatous and atheromatous arterial lesions in the albino rat. Arch. Path., 57:333.

    Google Scholar 

  • Wissler, R.W., 1968, The arterial medial cell, smooth muscle or multifunctional mesenchyme? J. Atheroscler. Res., 8:201.

    Article  Google Scholar 

  • Woerner, C.A., 1959, Vasa vasorum of arteries, their demonstration and distribution, in The Arterial Wall (A.I. Lansing, ed.) pp. 1–14, Billiére, Tindall and Cox, London.

    Google Scholar 

  • Wolinsky, H., and Glagov, S., 1967a, A lamellar unit of aortic medial structure and function in mammals. Circulat. Res., 20:99.

    Google Scholar 

  • Wolinsky, H., and Glagov, S., 1967b, Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. Circulat. Res., 20:409.

    Google Scholar 

  • Wolinsky, H., 1970, Response of the rat aortic wall to hypertension: importance of comparing absolute amounts of wall components. Atherosclerosis, 11:251.

    Article  Google Scholar 

  • Wolinsky, H., 1972, Long term effects of hypertension on the rat aortic wall and their relation to concurrent aging changes: morphological and chemical studies. Circulat. Res., 30:301.

    Google Scholar 

  • Wolman, M., and Bubis, J.J., 1965, The cause of the green polarization color of amyloid stained with Congo red. Histochemie, 4:351.

    Article  Google Scholar 

  • Wolman, M., 1971, Amyloid, its nature and molecular structure. Lab. Invest., 25:104.

    Google Scholar 

  • Wolman, M., 1974, Acid esterase as a factor in atheromatosis. Atherosclerosis, 20:217.

    Article  Google Scholar 

  • Wolman, M., and Gaton, E., 1976a, Macrophages and smooth muscle cells in the pathogenesis of atherosclerosis. J. Israel Med. Ass., 9:450.

    Google Scholar 

  • Wolman, M., and Gaton, E., 1976b, The role of acid esterase in the pathogenesis of atherosclerosis, in Proceedings of Vth International Congress of Histochemistry and Cytochemistry, Bucharest, p. 373.

    Google Scholar 

  • Woodard, J.F., Srinivasan, S.R., Zimny, M.L., Radhakrishnamurthy, B., and Berenson, G.S., 1976, Electron microscopic features of lipoprotein-glysaminoglycan complexes from human atherosclerotic plaques. Lab. Invest., 34:516.

    Google Scholar 

  • Wright, H.P., 1971, Areas of mitosis in aortic endothelium. J. Path., 105:65.

    Article  Google Scholar 

  • Wright, H.P., 1972, Mitosis patterns in aortic endothelium. Atherosclerosis, 15:93.

    Article  Google Scholar 

  • Wright. H.P., Evans, M., and Green, R.P., 1975, Aortic endothelial mitosis and Evans blue uptake in cholesterol-fed subscorbutic guinea-pigs. Atherosclerosis, 21:105.

    Article  Google Scholar 

  • Wright, J.R., and Calkins, E., 1974, Relationship of amyloid deposits in the human aorta to aortic atherosclerosis. Lab. Invest., 30:767.

    Google Scholar 

  • Wright, J.R., Calkins, E., and Humphrey, R.L., 1977, Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab. Invest., 36:274–281.

    Google Scholar 

  • Wurthier, R.E., and Irving, J.T., 1969, A study of the lipids in the rat aorta during induced calcification. Proc. Soc. Exp. Biol. (N.Y.), 130:156.

    Google Scholar 

  • Wyke, A.W., and Gardner, D.L., 1970, Microchemical determination of enzyme activities in small arteries of rats with early adrenal regeneration hypertension. Brit. J. Exp. Path., 51:512.

    Google Scholar 

  • Yardley, J.H., and Brown, G.D., 1965, Fibroblasts in tissue culture. Use of colloidal iron for ultrastructural localization of acid mucopolysaccharides. Lab. Invest., 14:501.

    Google Scholar 

  • Yodaiken, R.E., Seftel, H.C., Kew, M.C., Illenstein, M., and Ipp, E., 1969, Ultrastructure of capillaries in South African diabetics. II. Muscle capillaries. Diabetes, 18:164.

    Google Scholar 

  • Yu, S-Y., 1971, Cross linking of elastin in human atherosclerotic aortas. 1. A preliminary study. Lab. Invest., 25:121.

    Google Scholar 

  • Záhor, Z., Vaněček, R., Czabanová, V., Müller, J., and Komárková, A., 1967, The origin and development of the post-reproduction arteriopathy in female rats. J. Atheroscler. Res., 7:25.

    Article  Google Scholar 

  • Zemplényi, T., and Grafnetter, D., 1959, The lipolytic activity of heart and aorta in experimental atherosclerosis in rabbits. Brit. J. Exp. Path., 40:312.

    Google Scholar 

  • Zemplényi, T., Grafnetter, D., and Lojda, Z., 1961, Some problems connected with the lipolytic and esterolytic activity of tissues, in Enzymes of Lipid Metabolism (P. Desnuelle, ed.) pp. 203–212, Pergamon Press, New York.

    Google Scholar 

  • Zemplényi, T., and Mrhová, O., 1963, The Phosphomonoesterase and adenylpyrophosphatase activities of the aorta in different animal species. Brit. J. Exp. Path., 44:278.

    Google Scholar 

  • Zemplényi, T., Lojda, Z., and Mrhová, O., 1963a, Enzymes of the vascular wall in experimental atherosclerosis in the rabbit, in Atherosclerosis and Its Origin (M. Sandler and G.H. Bourne, eds.) p. 459, Academic Press, New York.

    Google Scholar 

  • Zemplényi, T., Mrhová, O., and Lojda, Z., 1963b, Phosphomonoesterase and adenylpyrophosphatase activities of the aorta in early stages of experimental rabbit atherosclerosis. J. Atheroscler. Res., 3:50.

    Article  Google Scholar 

  • Zemplényi, T., and Mrhová, Olga, 1965, Vascular enzyme activity changes accompanying the induction of experimental atherosclerosis. Part 2. Rats fed excess vitamin D. J. Atheroscler. Res., 5:548.

    Article  Google Scholar 

  • Zemplényi, T., 1968, Enzyme Biochemistry of the Arterial Wall, Lloyd Luke, London.

    Google Scholar 

  • Zemplényi, T., and Rosenstein, A.J., 1975, Arterial enzymes and their relation to atherosclerosis in pigeons. Exp. Molec. Path., 22:225.

    Article  Google Scholar 

  • Zilversmit, D.B., Shore, M.L., and Ackerman, R.F., 1954, Origin of aortic phospholipid in rabbit atheromatosis. Circulation, 9:581.

    Google Scholar 

  • Zilversmit, D.B., and Newman, H.A.I., 1966, Does a metabolic barrier to circulating cholesterol protect the arterial wall? Circulation, 33:7.

    Google Scholar 

  • Zilversmit, D.B., 1968, Cholesterol flux in the atherosclerotic plaque. Ann. N.Y. Acad. Sci., 149:710.

    Article  ADS  Google Scholar 

  • Zilversmit, D.B., 1970, Metabolism of arterial lipids, in Atherosclerosis, Proceedings of the 2nd International Symposium (R.J. Jones, ed.) p. 35, Springer, Berlin.

    Google Scholar 

  • Zilversmit, D.B., and Hughes, L.B., 1973, Incorporation in vivo of labeled cholesterol into aortas of young and old rabbits. Atherosclerosis, 18:141.

    Article  Google Scholar 

  • Zilversmit, D.B., Clarkson, T.B., and Hughes, L.B., 1977, High plasma cholesterol in mink (Mustela vison) without atherosclerosis. Atherosclerosis, 26:97–102.

    Article  Google Scholar 

  • Zugibe, F.T., and Brown, K.D., 1960, Histochemical studies in atherogenesis: human aortas. Circulat. Res., 8:287.

    Google Scholar 

  • Zugibe, F.T., and Brown, K.D., 1961, Histochemical studies in atherogenesis. Human cerebral arteries. Circulat. Res., 9:897.

    Google Scholar 

  • Zugibe, F.T., 1962a, The demonstration of the individual acid mucopolysaccharides in human aortas, coronary arteries and cerebral arteries. I. The methods. J. Histochem. Cytochem., 10:441.

    Article  Google Scholar 

  • Zugibe, F.T., 1962b, The demonstration of the individual acid mucopolysaccharides in human aortas, coronary arteries and cerebral arteries. II. Identification and significance with ageing. J. Histochem. Cytochem., 10:448.

    Article  Google Scholar 

  • Zugibe, F.T., 1963a, Histochemical studies of human coronary atherogenesis: comparison with aortic and cerebral atherogenesis. Circulat. Res., 13:401.

    Google Scholar 

  • Zugibe, F.T., 1963b, Mucopolysaccharides of the arterial wall. J. Histochem. Cytochem., 11:35.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Plenum Press, New York

About this chapter

Cite this chapter

Adams, C.W.M. (1981). Arterial Histochemistry in Relation to Structure, Function and Disease. In: Schwartz, C.J., Werthessen, N.T., Wolf, S. (eds) Structure and Function of the Circulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7927-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7927-4_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7929-8

  • Online ISBN: 978-1-4615-7927-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics