Skip to main content

Biochemical Studies on Permeability and the Interaction Between Blood Constituents and Arterial Components in Atherosclerosis

  • Conference paper
Atherosclerosis V

Abstract

It is now accepted that large amounts of plasma low density lipoprotein (LDL), and cholesterol ester which must be derived from it, accumulate in atherosclerotic lesions, but it is not clear if this is the result of increased endothelial permeability or of increased retention within the intima. In this paper I will try to draw together some of the available biochemical evidence.

The author’s research is supported by a grant from the Medical Research Council.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Armstrong ML, Megan MB, Warner EM (1978) The relation of hypercholesterolemic fatty streaks to intimai permeability changes shown by Evans blue. Atherosclerosis 31: 443

    Article  PubMed  CAS  Google Scholar 

  • Bell FP, Adamson IL, Schwartz CJ (1974a) Aortic permeability to albumin: focal and regional patterns of uptake and transmural distribution of 131-1-albumin in the young pig. Exp Mol Pathol 20: 57

    Article  PubMed  CAS  Google Scholar 

  • Bell FP, Gallus AS, Schwartz CJ (1974b) Focal and regional patterns of uptake and the transmural distribution of 131-I-fibrinogen in the pig aorta in vivo. Exp Mol Pathol 20: 281

    Article  PubMed  CAS  Google Scholar 

  • Bratzler RL, Chisolm GM, Colton CK, Smith KA, Zilversmit DB, Lees RS (1977a) The distribution of labelled albumin across the rabbit thoracic aorta in vivo. Circulation Res 40: 182

    PubMed  CAS  Google Scholar 

  • Bratzler RL, Chisolm GM, Colton CK, Smith KA, Lees RS (1977b) The distribution of labelled low-density lipoproteins across the rabbit thoracic aorta in vivo. Atherosclerosis 28: 289

    Article  PubMed  CAS  Google Scholar 

  • Fry DL (1973) Responses of the arterial wall to certain physical factors. In: Atherogenesis: Initiating factors. Ciba Foundation Symposium (New Series) 12: 93

    Google Scholar 

  • Gerrity RG, Richardson M, Somer JB, Bell FP, Schwartz CJ (1977) Endothelial cell morphology in areas of in vivo Evans blue uptake in the aorta of young pigs. Am J Pathol 89: 313

    PubMed  CAS  Google Scholar 

  • Hoff HF, Gaubatz JW, Gotto AM (1978a) Apo B concentration in the normal human aorta. Biochem Biophys Res Com 84: 1424

    Article  Google Scholar 

  • Hoff HF, Heideman CL, Gaubatz JW, Titus JL, Gotto AM (1978b) Quantitation of apo B in human aortic fatty streaks. Atherosclerosis 30: 263

    Article  PubMed  CAS  Google Scholar 

  • Hollande W (1967) Influx, synthesis and transport of arterial lipoproteins in atherosclerosis. Exp Mol Pathol 7: 248

    Article  Google Scholar 

  • Hollande W (1976) Unified concept on the role of acid mucopolysaccharides and connective tissue proteins in the accumulation of lipids, lipoproteins and calcium in the atherosclerotic plaque. Exp Mol Pathol 25: 106

    Article  Google Scholar 

  • Minick CR, Stemerman MB, Insul W (1977) Effect of regenerated endothelium on lipid accumulation in the arterial wall. Proc Natl Acad Sci USA 74: 1724

    Article  Google Scholar 

  • Morrison AD, Berwick L, Orci L, Winegrad AI (1976) Morphology and metabolism of an aortic intima-media preparation in which an intact endothelium is preserved. J Clin Invest 57: 650

    Article  PubMed  CAS  Google Scholar 

  • Packham MA, Rowsell HC, Jorgensen L, Mustard JF (1967) Localized protein accumulation in the wall of the aorta. Exp Mol Pathol 7: 214

    Article  PubMed  CAS  Google Scholar 

  • Siflinger A, Parker K, Caro CG (1975) Uptake of 125-I-albumin by the endoth-elial surface of the isolated dog common carotid artery: effect of certain physical factors and metabolic inhibitors. Cardiovasc Res 9: 478

    Article  PubMed  CAS  Google Scholar 

  • Smith EB (1974) The relationship between plasma and tissue lipids in human atherosclerosis. Advan Lipid Res 12: 1

    CAS  Google Scholar 

  • Smith EB (1980) Transport of macromolecules across the artery wall. This volume

    Google Scholar 

  • Smith EB, Craig IB, Dietz HS (1978) Factors influencing accumulation and destruction of lipoprotein in atherosclerotic lesions. In: Carlson LA, Paoletti R, Sirtori CR, Weber G (eds) International Conference on Atherosclerosis, Raven Press, New York, p 49

    Google Scholar 

  • Smith EB, Dietz HS, Craig IB (1979a) Characterization of free and tightly bound lipoprotein in intima by thin layer isoelectric focusing. Atherosclerosis 33: 329

    Article  PubMed  CAS  Google Scholar 

  • Smith EB, Massie IB, Alexander KM (1976) The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin. Atherosclerosis 25: 71

    Article  PubMed  CAS  Google Scholar 

  • Smith EB, Staples EM, Dietz HS, Smith RH (1979) Role of endothelium in sequestration of lipoprotein and fibrinogen in aortic lesions, thrombi and graft pseudo-intimas. Lancet ii: 812

    Article  Google Scholar 

  • Stefanovich V, Gor I (1971) Cholesterol diet and permeability of rabbit aorta. Exp Mol Pathol 14: 20

    Article  PubMed  CAS  Google Scholar 

  • Thorgeirsson G, Robertson AL (1978) The vascular endothelium — pathobiologic significance. Am J Pathol 93: 803

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Antonio M. Gotto Jr. Louis C. Smith Barbara Allen

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag New York Inc.

About this paper

Cite this paper

Smith, E.B. (1980). Biochemical Studies on Permeability and the Interaction Between Blood Constituents and Arterial Components in Atherosclerosis. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-6071-4_24

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6073-8

  • Online ISBN: 978-1-4612-6071-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics