Abstract
Since the original observation made over 100 years ago that cholesterol accumulates in the arterial wall in atherosclerosis, great interest has been placed on the histology, chemistry, biochemistry, cytochemistry and physical chemistry of the arterial wall. I wish to briefly bring together some facts concerning the lipids of the arterial wall and the changes that occur during the development of the advanced atherosclerotic plaque.
Supported by U.S. Public Health Service Grants HL-18673, HL-13272 and Training Grant HL-07291.
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References
Day AJ, Wahlquist ML (1970) Cholesterol ester and phospholipid composition of normal aortas and of atherosclerotic lesions in children. Exp Mol Pathol 13: 199–216
Hata Y, Insull Jr, W (1973) Significance of cholesterol esters as liquid crystal in human atherosclerosis. Jpn Cire J 37: 269–275
Hoff HF, Heideman CL, Gaubatz JW (1980) Low density lipoproteins in the aorta: Relation to atherosclerosis. This volume
Hollander W, Paddock J, Colomb M (1979) Lipoproteins in human atherosclerotic vessels. Exp Mol Path 30: 144–171
Katz SS, Shipley GG, Small DM (1976) Physical chemistry of the lipids of human atherosclerotic lesions. Demonstrations of a lesion intermediate between fatty streaks and advance plaques. J Clin Invest 58: 200–211
Katz SS, Small DM, Brooks JG et al. (1976a) The physical state of lipids in foam cells of Tangier disease and human atherosclerotic plaques. Circulation 53, 54: Suppl 2: 11–180
Lang PD, Insull jr W (1970) Lipid droplets in atherosclerotid fatty streaks of human aorta. J Clin Invest 49: 1479–1488
Small DM, Shipley GG (1974) Physical-chemical basis of lipid deposition in atherosclerosis. Science 185: 222–229
Small DM (1977) Liquid crystals in living and dying systems. J Colloid and Interface Sci 58: 581–602
Small DM (1977a) Cellular mechanisms for lipid deposition in atherosclerosis. NEJM (Seminars in Medicine) 297: 873–877 & 924-929
Smith EB (1965) The influence of age and atherosclerosis on the chemistry of aortic intima. Part I. The lipids. Atheroscler Res 5: 224–240
Smith EB, Evans PH, Downham MD (1967) Lipid in the aortic intima. The correlation of morphological and chemical characteristics. J Atheroscler Res 7: 171–186
Smith EB, Slater RS (1972) The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. Part I. The lipids in the isolated fractions. Atheroscl 15: 37–56
Smith EB (1980) Transport of macromolecules across the artery wall. This volume
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Small, D.M. (1980). Summary of Concepts Concerning the Arterial Wall and Its Atherosclerotic Lesions. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_102
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DOI: https://doi.org/10.1007/978-1-4612-6071-4_102
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