Abstract
Cells overloaded with lipid droplets are one of the main characteristics of lesions associated with hypercholesterolemia. Accumulation and degradation of droplet inclusions are accompanied by characteristic ultrastructural changes within the cells. We have investigated the stages in droplet degradation while studying regressing atherosclerotic lesions in groups of monkeys killed at short intervals after lowering high serum cholesterol levels by diet. This paper reports on differences in the rate whereby the two main cell types of lesions, smooth muscle cells and macrophages, degrade droplets. We have already reported that the labeling index of cells decreased in the aortic lesions of these animals after we lowered the serum cholesterol (Stary 1974), and that cell death was the cause of the disappearance of macrophage foam cells (Stary 1977).
Supported by N.I.H., Program Project Grant HL-08974.
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Stary, H.C., Strong, J.P., Eggen, D.A. (1980). Differences in the Degradation-Rate of Intracellular Lipid Droplets in the Intimal Smooth Muscle Cells and Macrophages of Regressing Atherosclerotic Lesions of Primates. In: Gotto, A.M., Smith, L.C., Allen, B. (eds) Atherosclerosis V. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-6071-4_143
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DOI: https://doi.org/10.1007/978-1-4612-6071-4_143
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