Nephrotoxicity

In Vitro to In Vivo Animals to Man

  • P. H. Bach
  • E. A. Lock

Table of contents

  1. Front Matter
    Pages i-xx
  2. Key Note Lecture

  3. Heavy Metal Toxicity

    1. R. A. Goyer, C. R. Weinberg, W. M. Victery, C. R. Miller
      Pages 11-20
    2. Gary L. Diamond, Thomas W. Clarkson, John B. Hursh, M. George Cherian
      Pages 21-31
    3. Harry Roels, Robert Lauwerys, Jean-Pierre Buchet, Alfred Bernard, Alfons Vos, Maurice Oversteyns
      Pages 33-36
    4. Alfred Bernard, Ali Ouled Amor, Harry Roels, Robert Lauwerys
      Pages 37-41
    5. Chiharu Tohyama, Naoko Sugihira, Kazuo T. Suzuki, Masataka Murakami, Hiroshi Saito
      Pages 43-49
    6. Vera R. Porter, Dora B. Weiner
      Pages 51-57
    7. R. O. Blackburn, D. N. Prashad, C. Whitehead
      Pages 65-70
    8. E. Elger, R. Sievers, B. Elger, C. J. Olbricht, H. Stolte
      Pages 71-74
    9. Z. H. Endre, L. G. Nicholls, P. J. Ratcliffe, J. G. G. Ledingham
      Pages 103-106
    10. H. J. Mason, L. J. Somervaille, D. R. Tennant, D. R. Chettle, M. C. Scott
      Pages 113-118
    11. F. Khalil-Manesh, H. C. Gonick, E. Weiler, V. Rosen, L. Roche, A. Mutti et al.
      Pages 119-126

About this book

Introduction

There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.

Keywords

development etiology evaluation homeostasis immunology kidney renal failure safety toxicity

Editors and affiliations

  • P. H. Bach
    • 1
  • E. A. Lock
    • 2
  1. 1.The Robens Institute of Industrial and Environmental Health and SafetyUniversity of SurreyGuildford, SurreyUK
  2. 2.ICI Central Toxicology LaboratoryMacclesfield, CheshireUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-2040-2
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-2042-6
  • Online ISBN 978-1-4757-2040-2
  • About this book