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Induction of Antinuclear Antibodies by Mercuric Chloride in Mice

  • P. Hultman
  • S. Enestrom

Abstract

Reports suggest that exposure to low doses of mercury or mercuric compounds in man could lead to proteinuria or nephrotic syndrome (Kazantzis, 1962; Belghiti et al, 1986). Immunologically mediated glomerulonephritis (GN) of IC type has been described in such patients (Gaultier et al, 1968; Tubbs et al, 1982). The closer mechanism of action in human mercury-induced glomerular disease remains unknown, but there is evidence that mercury can modify the immunoregulation (Charpentier et al, 1981) .

Keywords

Mercury Capron Bismuth Proteinuria Nephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aarden, L.A., de Groot, E.R., and Feltkamp, T.E.W., 1975, Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA, with the immunof luorescent technique, Ann N.Y. Acad Sci., 245:505.CrossRefGoogle Scholar
  2. Bariety, J., Druet, F., Laliberte, F., and Sapin, C., 1971, Glomerulonephritis with gamma- and ßIC globulin deposits induced in rats by mercuric chloride, Am J Pathol., 65:293.PubMedGoogle Scholar
  3. Bartolotti, S.R., 1977, Quantitative elution studies in experimental immune complex and nephrotoxic nephritis, Clin Exp Immunol., 29:334.PubMedGoogle Scholar
  4. Belghiti, D., Patey, O., Berry, J. P. , Antelin, C., Hirbec, G., and Lagrue, G., 1986, Nephrose lipoidique d’origine “toxique” Deux cas, Presse M’edicale, 15:1953.Google Scholar
  5. Bernaudin, J.F., Druet, E., Druet, P., and Masse, R., 1981, Inhalation or ingestion of organic or inorganic mercurials produces autoimmune disease in rats, Clin Immunol Immunopathol., 20:129.PubMedCrossRefGoogle Scholar
  6. Bellon, B., Capron, M., Druet, E., Verroust, P., Vial, M-C . , Sapin, C., Girard, J.F., Foidart, J.M., Mahieu, P., and Druet, P., 1982, Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes, Eur J Clin Invest., 12:127.PubMedCrossRefGoogle Scholar
  7. Cooke, A., and Hutchings, P., 1983, Defective regulation of erythrocyte autoantibodies in SJL mice, Immunology., 51:489.Google Scholar
  8. Bernstein, R.M., Steigewald, J.C., and Tan, E.M., 1982, Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis, Clin Exp Immunol., 48:43.PubMedGoogle Scholar
  9. Charpentier, B., Moullot, Ph., Faux, N., Manigand, G., and Fries, D., 1981, Functions lymphocytaires T au cours d’une glomerulonephrite extramembraneuse induite par une intoxication chronique au mercure, N’ ephrologie, 2:153.Google Scholar
  10. Druet, E., Sapin, C., Fournie, G., Mandet, C., Gnther, E., and Druet, P., 1982, Genetic control of susceptibility to mercury-induced immune nephritis in various strains of rat, Clin Immunol Immunopathol., 25:203.PubMedCrossRefGoogle Scholar
  11. Druet, P., Druet, E., Potdevin, F., and Sapin, C., 1978, Immune type glomerulonephritis induced by HgCl2 in the Brown Norway rat, Ann Immunol., 129:777.Google Scholar
  12. Enestrom, S., and Hultman, P., 1984, Immune-mediated glomerulonephritis induced by mercuric chloride in mice, Experientia, 40:1234.PubMedCrossRefGoogle Scholar
  13. Fritzler, M.J., and Tan, E.M., 1978, Antibodies to histones in druginduced and idiopathic lupus erythematosus, J Clin Invest., 62:560.PubMedCrossRefGoogle Scholar
  14. Gaultier, M., Fournier, E., Gervais, P., Morel-Maroger, L., Bismuth, C., and Rain, J.-D., 1968 Deux cas de syndrome nephrotique dans une fabrique de thermometres, Soc Med Hopit Paris, 119:47.Google Scholar
  15. Gerber, M.A., 1975, Immunohistochemical findings in the renal vascular lesions of progressive systemic sclerosis, Hum Pathol., 6:343.PubMedCrossRefGoogle Scholar
  16. Haynes, D.C., and Gershwin, M.E., 1982, The immunopathology of progressive systemic sclerosis (PSS), Semin Arthr Rheumat., 11:331.CrossRefGoogle Scholar
  17. Heptinstall, R.H., 1983, Hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and systemic scleroderma (progressive systemic sclerosis), In: “Pathology of the Kidney”, Little Brown and Company, Boston and Toronto.Google Scholar
  18. Hirsch, F., Couderc, J., Sapin, S., Fournie, G., and Druet, P., 1982, Polyclonal effect of HgCl2 in the rat, its possible role in an experimental autoimmune disease, Eur J Immunol., 12:620.PubMedCrossRefGoogle Scholar
  19. Hultman, P., and Enestrom., 1987, The induction of immune complex deposits in mice by peroral and parenteral administration of mercuric chloride: strain dependent susceptibility, Clin Exp Immunol., 67:283.PubMedGoogle Scholar
  20. Jimenez, S.A., 1983, Cellular Immune dysfunction and the pathogenesis of scleroderma, Semin Arthr Rheumat., 13:104.CrossRefGoogle Scholar
  21. Kazantzis, G., Schiller, K.F.R., Asscher, A.W., and Drew, R.G., 1961, Albuminuria and the nephrotic syndrome following exposure to mercury and its compounds, Q J Med., 124:403.Google Scholar
  22. McCoy, R. C. , Tisher, C.C., Pepe, P. F . , and Cleveland, L. A., 1976, The kidney in progressive systemic sclerosis. Immunohistochemical and antibody elution studies, Lab Invest., 35:124.PubMedGoogle Scholar
  23. Nakamura, R.M., Tan, E.M., 1986, Recent advances in laboratory tests and the significance of autoantibodies to nuclear antigens in systemic rheumatic diseases, Clin. Lab. Med., 6:41..PubMedGoogle Scholar
  24. Ochs, R. L. , Lischwe, M.A., Spohn, W. H. , and Busch, H., 1985, Fibrillarin: a new protein of the nucleolus identified by autoimmune sera, Biol Cell., 54:123.PubMedCrossRefGoogle Scholar
  25. Pinnas, J.L., Northway, J.D., and Tan, E.M., 1973, Antinucleolar antibodies in human sera, J Immunol., 3:996.Google Scholar
  26. Riboldi, P., Asero, R., Origgi, L., Crespi, S., Meroni, P.L., Sguotti, C., and Sabbadini, M.G., 1985, Antinuclear antibodies in progressive systemic sclerosis, Clin Exp Rheumatol., 3:205.PubMedGoogle Scholar
  27. Robinson, C. J. G. , Abraham, A. A., and Balazs, T., 1984, Induction of antinuclear antibodies by mercuric chloride in mice, Clin Exp Immunol., 58:300.PubMedGoogle Scholar
  28. Sapin, C., Druet, E., and Druet, P., 1977, Induction of anti-glomerular basement membrane antibodies in the Brown-Norway rat by mercuric chloride, Clin Exp Immunol., 28:173.PubMedGoogle Scholar
  29. Sharp, G.C., Irvin, W.S., Tan, E.M., Gould, R.G., and Holman, H.R., 1972, Mixed connective tissue disease — an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA) , Am J Med., 52:148.PubMedCrossRefGoogle Scholar
  30. Stetler, D.A., Sipes, D.E., and Jacob, S.T., 1985, Anti-RNA polymerase I antibodies in sera of MRL 1pr/lpr and MRL +/+ autoimmune mice. Correlation 90 of antibody production with delayed onset of lupus-like disease in MRL +/+ mice, J Exp Med., 162:1760.PubMedCrossRefGoogle Scholar
  31. Sung, M.T., Harford, J., Bundman, M., and Vidalakas, G., 1977, Metabolism of histones in avian erythroid cells, Biochemistry, 16:279.PubMedCrossRefGoogle Scholar
  32. Tan, E.M., Robinson, J., and Robitaille, P., 1976, Studies on antibodies to histones by immunof luorescence, Scand J Immunol. , 5:811.PubMedCrossRefGoogle Scholar
  33. Tubbs, R.R., Gephardt, G.N., McMahon, J.T., Pohl, M.C., Vidt, D.G., Barenberg, S.A., and Valenzuela, R., 1982, Membranous glomerulonephritis associated with industrial mercury exposure, Am J Clin Pathol., 1982:409.Google Scholar
  34. Weening, J.J., Fleuren, G.J., and Hoedemaeker, Ph.J., 1978, Demonstration of antinuclear antibodies in mercuric chloride-induced glomerulopathy in the rat, Lab Invest., 39:405.PubMedGoogle Scholar
  35. Weening, J.J., Grond, J., van der Top, D., and Hoedemaeker, Ph.J., 1980, Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat, Invest Cell Pathol., 3:129.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. Hultman
    • 1
  • S. Enestrom
    • 1
  1. 1.Department of Pathology IUniversity of LinköpingSweden

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