Regioselective Acute Tubular Necrosis in Renal Cortical Slices Following HgCl2 and K2Cr2O7: Localization and Transport Studies
Recently, the selective necrosis of renal convoluted (CPT) and straight proximal tubules (SPT) following administration of K2Cr2O7 and HgCl2, respectively, has been reproduced in renal cortical slices (Ruegg et al, 1987a). This demonstrates that the toxicity of these two metals results from the innate sensitivity of these segments of the nephron to the specific metal and is not a result of altered blood flow or feed-back mechanisms . The question remains as to why these nephron segments are specifically intoxicated. Is it the result of a specific uptake and localization of the metals in the intoxicated cells?
KeywordsToxicity Sulfide Mercury Chromium Glutathione
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- Hassall CD, Gandolfi AJ, Brendel K. Effect of halogenated vinyl cysteine conjugates on renal tubular active transport . Toxicology 26:285–294, 1983 .Google Scholar
- Mescon H and Flesch P . Modification of Bennett’ s method for the histochemical demonstration of free sulfhydryl groups in skin. J Invest Dermatology 17:261–266, 1952 .Google Scholar
- Ruegg CE, Gandolfi AJ, Brendel K, Nagle FB. Differential Patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions . Toxicol Appl Pharmacol, in press, 1987a.Google Scholar
- Ruegg CE. Mechanisms underlying regioselective acute tubular necrosis of renal proximal tubular segments. Doctoral Thesis, University of Arizona, 1987c.Google Scholar