Transition States of Biochemical Processes

  • Richard D. Gandour
  • Richard L. Schowen

Table of contents

  1. Front Matter
    Pages i-xix
  2. The Role of the Transition State in Chemical and Biological Catalysis

    1. Front Matter
      Pages 1-1
    2. Elizabeth K. Thornton, Edward R. Thornton
      Pages 3-76
    3. Richard L. Schowen
      Pages 77-114
  3. Approaches to the Determination of Biochemical Transition-State Structures and Properties

    1. Front Matter
      Pages 115-117
    2. Gerald M. Maggiora, Ralph E. Christoffersen
      Pages 119-163
    3. Judith P. Klinman
      Pages 165-200
    4. John L. Hogg
      Pages 201-224
    5. Katharine B. J. Schowen
      Pages 225-283
  4. Studies of Transition-State Properties in Enzymic and Related Reactions

    1. Front Matter
      Pages 353-353
    2. Mohamed F. Hegazi, Daniel M. Quinn, Richard L. Schowen
      Pages 355-428
    3. S. J. Benkovic, K. J. Schray
      Pages 493-527
    4. Richard D. Gandour
      Pages 529-552
  5. Applications of Biochemical Transition-State Information

    1. Front Matter
      Pages 553-553

About this book

Introduction

The transItIOn-state theory has been, from the point of its inception, the most influential principle in the development of our knowledge of reaction mechanisms in solution. It is natural that as the field of biochemical dynamics has achieved new levels of refinement its students have increasingly adopted the concepts and methods of transition-state theory. Indeed, every dynamical problem of biochemistry finds its most elegant and economical statement in the terms of this theory. Enzyme catalytic power, for example, derives from the interaction of enzyme and substrate structures in the transition state, so that an understanding of this power must grow from a knowledge of these structures and interactions. Similarly, transition-state interactions, and the way in which they change as protein structure is altered, constitute the pivotal feature upon which molecular evolution must turn. The complete, coupled dynamical system of the organism, incorporating the transport of matter and energy as well as local chemical processes, will eventually have to yield to a description of its component transition-state structures and their energetic response characteristics, even if the form of the description goes beyond present-day transition-state theory. Finally, the importance of biochemical effectors in medicine and agriculture carries the subject into the world of practical affairs, in the use of transition-state information for the construction of ultra potent biological agents.

Keywords

agriculture biochemistry biological chemistry drug design energy enzyme enzymes evolution medicine protein protein structure structure system transport

Editors and affiliations

  • Richard D. Gandour
    • 1
  • Richard L. Schowen
    • 2
  1. 1.Department of ChemistryLouisiana State UniversityBaton RougeUSA
  2. 2.Department of ChemistryUniversity of KansasLawrenceUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4684-9978-0
  • Copyright Information Springer-Verlag US 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-9980-3
  • Online ISBN 978-1-4684-9978-0
  • About this book