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Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths

  • Gerald M. Maggiora
  • Ralph E. Christoffersen

Abstract

Over the last 30 years, transition-state theory has provided a suitable theoretical framework for interpreting a wide range of chemical(1) and biological(2) processes. Nevertheless, it is only within the last few years, due in large measure to the approximately parallel and related development of high-speed digital computers and practical quantum-mechanical procedures for studying the geometric and electronic structure of molecules, that the full potential of transition-state theory is beginning to be realized.

Keywords

Transition State Potential Energy Surface Reaction Path Potential Energy Function Kinetic Isotope Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Gerald M. Maggiora
    • 1
  • Ralph E. Christoffersen
    • 1
  1. 1.Departments of Biochemistry and ChemistryUniversity of KansasLawrenceUSA

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