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Microbial production of 2,3-butanediol for industrial applications

  • Bioenergy/Biofuels/Biochemicals - Review
  • Published:
Journal of Industrial Microbiology & Biotechnology

Abstract

2,3-Butanediol (2,3-BD) has great potential for diverse industries, including chemical, cosmetics, agriculture, and pharmaceutical areas. However, its industrial production and usage are limited by the fairly high cost of its petro-based production. Several bio-based 2,3-BD production processes have been developed and their economic advantages over petro-based production process have been reported. In particular, many 2,3-BD-producing microorganisms including bacteria and yeast have been isolated and metabolically engineered for efficient production of 2,3-BD. In addition, several fermentation processes have been tested using feedstocks such as starch, sugar, glycerol, and even lignocellulose as raw materials. Since separation and purification of 2,3-BD from fermentation broth account for the majority of its production cost, cost-effective processes have been simultaneously developed. The construction of a demonstration plant that can annually produce around 300 tons of 2,3-BD is scheduled to be mechanically completed in Korea in 2019. In this paper, core technologies for bio-based 2,3-BD production are reviewed and their potentials for use in the commercial sector are discussed.

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Acknowledgements

This work was supported by the Industrial Strategic Technology Development Program (No. 10050407) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).

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  1. Research and Development Center, GS Caltex Corporation, Yuseong-gu, Daejeon, 34122, South Korea

    Chan Woo Song, Jong Myoung Park, Sang Chul Chung & Hyohak Song

  2. Department of Chemical and Biomolecular Engineering (BK21 Plus Program), BioProcess Engineering Research Center, Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea

    Sang Chul Chung & Sang Yup Lee

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Song, C.W., Park, J.M., Chung, S.C. et al. Microbial production of 2,3-butanediol for industrial applications. J Ind Microbiol Biotechnol 46, 1583–1601 (2019). https://doi.org/10.1007/s10295-019-02231-0

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