Volume 31, Issue 7

Search all Medicinal Chemistry Research articles

July 2022

Special Issue in Honor of Prof. Laurence H. Hurley for His Many Contributions in Medicinal Chemistry and Drug Discovery

Issue Editors:

Wei Wang,
Myron K. Jacobson,
Elaine L. Jacobson

15 articles in this issue

Special issue in honor of Prof. Laurence H. Hurley
Myron K. Jacobson
Wei Wang
Elaine L. Jacobson
Editorial 20 May 2022 Pages: 1061 - 1063
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Useful preclinical clues that a proposed new therapy would work in the clinic: to make a medicinal chemist’s dreams come true
Daniel D. Von Hoff
Haiyong Han
Editorial 02 June 2022 Pages: 1064 - 1067
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Molecular glues: enhanced protein-protein interactions and cell proteome editing
Evita G. Weagel
Jason M. Foulks
Steven L. Warner
Review Article Open access 12 May 2022 Pages: 1068 - 1087
Part of 3 collections:

Protein-protein interactions

Drug Design reviews

Special Issue in honor of Prof. Laurence Hurley
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
Chandrashekhar Madasu
Ya-Ming Xu
A. A. Leslie Gunatilaka
Original Research 17 January 2022 Pages: 1088 - 1098
Part of 3 collections:

Drug Design reviews

Most Cited Articles in Medicinal Chemistry Research, 2022

Special Issue in honor of Prof. Laurence Hurley
Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents
Zheng-Rong Wu
Wei Deng
Dian He
Original Research 24 January 2022 Pages: 1099 - 1108
Part of 2 collections:

Prodrugs

Special Issue in honor of Prof. Laurence Hurley
Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1)
Prince J. Salvador
Heather B. Jacobs
Ahmed M. Awad
Original Research 28 January 2022 Pages: 1109 - 1119
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
A vitamin D C/D ring-derived compound with cytotoxicity
Alaa N. Hassan
Tsugumasa Toma
Masami Otsuka
Original Research 02 February 2022 Pages: 1120 - 1125
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
A reliable and automated synthesis of 6-[¹⁸F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants
Zhengwei Zhang
Jingjie Ge
Jianhua Zhu
original research 05 February 2022 Pages: 1126 - 1134
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief
Wafaa Alabsi
Timothy Jaynes
Robin Polt
Original Research 08 April 2022 Pages: 1135 - 1146
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
Haozhou Tan
Chunlong Ma
Jun Wang
Original Research 12 May 2022 Pages: 1147 - 1153
Part of 2 collections:

SARS-CoV-2

Special Issue in honor of Prof. Laurence Hurley
Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors
Giri R. Gnawali
Koichi Okumura
Andrew S. Kraft
Original Research 26 May 2022 Pages: 1154 - 1175
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds
Aaron G. Dale
Alessandra Porcu
Stephen Neidle
Original Research Open access 16 June 2022 Pages: 1176 - 1191
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities
Ronak Haj Ersan
Burak Kuzu
Oztekin Algul
Original Research 16 May 2022 Pages: 1192 - 1208
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Discovery of novel, selective, functionalized 5-(2-(5-arylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)ethyl)-γ-butyrolactone sigma-2 ligands
Benjamin E. Blass
Kevin M. Blattner
Daniel J. Canney
Original Research 18 May 2022 Pages: 1209 - 1223
Part of 1 collection:

Special Issue in honor of Prof. Laurence Hurley
Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma
Jin-Jin Sun
Jin-Ping Wang
Ji-Jun Chen
Original Research 24 May 2022 Pages: 1224 - 1239

Volume 31, Issue 7

Special issue in honor of Prof. Laurence H. Hurley

Useful preclinical clues that a proposed new therapy would work in the clinic: to make a medicinal chemist’s dreams come true

Molecular glues: enhanced protein-protein interactions and cell proteome editing

Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin

Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents

Synthesis and in silico evaluation of novel uridyl sulfamoylbenzoate derivatives as potential anticancer agents targeting M1 subunit of human ribonucleotide reductase (hRRM1)

A vitamin D C/D ring-derived compound with cytotoxicity

A reliable and automated synthesis of 6-[¹⁸F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

Synthesis of alamandine glycoside analogs as new drug candidates to antagonize the MrgD receptor for pain relief

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors

The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds

2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities

Discovery of novel, selective, functionalized 5-(2-(5-arylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)ethyl)-γ-butyrolactone sigma-2 ligands

Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma

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