Collection
Prodrugs
The following articles were selected by the editors as some of the best research recently published in Medicinal Chemistry Research on prodrugs. This list is current to 1 October, 2023.
Articles (36 in this collection)
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Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus
Authors (first, second and last of 6)
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Synthesis and anticancer activity of Boc-Gly-Pro dipeptide-annonaceous acetogenin prodrugs targeting fibroblast activation protein or other hydrolytic enzymes
Authors (first, second and last of 5)
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An insight into prodrug strategy for the treatment of Alzheimer’s disease
Authors (first, second and last of 6)
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Conjugates of Tetramethylpyrazine’ metabolites and amino acid as potential antiplatelet agents
Authors (first, second and last of 11)
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Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)
Authors
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Synthesis and biological evaluation of pyrrolidine-functionalized nucleoside analogs
Authors (first, second and last of 8)
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Phosphoramidate conjugates of 3′-azido-3′-deoxythymidine glycerolipid derivatives and amino acid esters: synthesis and anti-HIV activity
Authors (first, second and last of 5)
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Synthesis, biological evaluation and molecular docking studies of Combretastatin A-4 phosphoramidates as novel anticancer prodrugs
Authors (first, second and last of 7)
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Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents
Authors (first, second and last of 6)
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Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study
Authors (first, second and last of 13)
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Ethyl phosphoramidates of acyclovir: design, synthesis, molecular docking (HN Protein), and evaluation of antiviral and antioxidant activities
Authors (first, second and last of 7)
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Prostaglandin analogues: current treatment option for glaucoma
Authors (first, second and last of 4)
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Synthesis, crystal structure, biological evaluation, electronic aspects of hydrogen bonds, and QSAR studies of some new N-(substituted phenylurea) diazaphosphore derivatives as anticancer agents
Authors (first, second and last of 4)
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Synthesis and pharmacological evaluation of mutual prodrugs of aceclofenac with quercetin, vanillin and l-tryptophan as gastrosparing NSAIDS
Authors (first, second and last of 6)
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Synthesis, cyclooxygenase inhibition, and anti-inflammatory evaluation of novel diarylheterocycles with a central pyrazole, pyrazoline, or pyridine ring
Authors (first, second and last of 4)
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l-Amino acid carbamate prodrugs of scutellarin: synthesis, physiochemical property, Caco-2 cell permeability, and in vitro anti-oxidative activity
Authors (first, second and last of 13)
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Novel ibuprofen prodrugs with improved pharmacokinetics and non-ulcerogenic potential
Authors (first, second and last of 6)
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Synthesis and biological evaluation of ester derivatives of indomethacin as selective COX-2 inhibitors
Authors (first, second and last of 4)
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Design, synthesis and evaluation of novel indomethacin–flavonoid mutual prodrugs as safer NSAIDs
Authors
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The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity
Authors (first, second and last of 5)
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Substituted aminoalcohol ester analogs of indomethacin with reduced toxic effects
Authors (first, second and last of 4)
