The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism
Authors (first, second and last of 4)
Collection
Drug Design reviews
The following articles were selected by the editors as some of the best review articles published in Medicinal Chemistry Research on drug design. This list is current to 1 October, 2023.
Articles (27 in this collection)
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A guide for the synthesis of key nucleoside scaffolds in drug discovery
Authors (first, second and last of 4)
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The rise of targeting chimeras (TACs): next-generation medicines that preempt cellular events
Authors (first, second and last of 10)
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A MIST conception: what has been learned from twenty years of human metabolite safety assessment?
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An update on the discovery and development of reversible covalent inhibitors
Authors (first, second and last of 4)
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Medicinal chemistry insights into non-hydroxamate HDAC6 selective inhibitors
Authors (first, second and last of 4)
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Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations
Authors (first, second and last of 4)
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Antimicrobial activity of quaternary ammonium salts: structure-activity relationship
Authors (first, second and last of 8)
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Molecular glues: enhanced protein-protein interactions and cell proteome editing
Authors (first, second and last of 4)
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Evaluation of novel multifunctional organoselenium compounds as potential cholinesterase inhibitors against Alzheimer’s disease
Authors (first, second and last of 4)
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Design, synthesis and biological evaluation of 8-aminoquinoline-1,2,3-triazole hybrid derivatives as potential antimicrobial agents
Authors (first, second and last of 4)
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An insight into prodrug strategy for the treatment of Alzheimer’s disease
Authors (first, second and last of 6)
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Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies
Authors (first, second and last of 4)
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Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
Authors (first, second and last of 6)
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Isatin derivatives as broad-spectrum antiviral agents: the current landscape
Authors (first, second and last of 7)
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Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers
Authors (first, second and last of 5)
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Design, synthesis, in vitro evaluation, and docking studies on ibuprofen derived 1,3,4-oxadiazole derivatives as dual α-glucosidase and urease inhibitors
Authors (first, second and last of 13)
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Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
Authors (first, second and last of 4)
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Rheostat positions: A new classification of protein positions relevant to pharmacogenomics
Authors (first, second and last of 5)
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