1. Neuroprotective Effect of Lentivirus-Mediated FGF21 Gene Delivery in Experimental Alzheimer’s Disease is Augmented when Concerted with Rapamycin

   • Violina Kakoty
   • Sarathlal K C
   • Rajeev Taliyan

   OriginalPaper 10 February 2022 Pages: 2659 - 2677

   

2. Microglia in Alzheimer’s Disease: An Unprecedented Opportunity as Prospective Drug Target

   • Bhargavi Kulkarni
   • Natália Cruz-Martins
   • Dileep Kumar

   ReviewPaper 12 February 2022 Pages: 2678 - 2693

   

3. MicroRNA-22: a Novel and Potent Biological Therapeutics in Neurological Disorders

   • Seyed Hamidreza Rastegar-moghaddam
   • Alireza Ebrahimzadeh-Bideskan
   • Abbas Mohammadipour

   ReviewPaper 14 February 2022 Pages: 2694 - 2701

   

4. N-acetylcysteine aggravates seizures while improving depressive-like and cognitive impairment comorbidities in the WAG/Rij rat model of absence epilepsy

   • Martina Tallarico
   • Antonio Leo
   • Rita Citraro

   OriginalPaper 15 February 2022 Pages: 2702 - 2714

   

5. Extracellular Vesicles from Gram-positive and Gram-negative Probiotics Remediate Stress-Induced Depressive Behavior in Mice

   • Juli Choi
   • Hyejin Kwon
   • Pyung-Lim Han

   OriginalPaper 16 February 2022 Pages: 2715 - 2728

   

6. Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats

   • Rukmani Pandey
   • Asmita Garg
   • Sanghamitra Bandyopadhyay

   OriginalPaper 17 February 2022 Pages: 2729 - 2744

   

7. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells

   • Erin McCarthy
   • Aaron Barron
   • Gerard W. O’Keeffe

   OriginalPaper Open access 17 February 2022 Pages: 2745 - 2757

   

8. Post-stroke Impairment of the Blood–Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway

   • Aishika Datta
   • Deepaneeta Sarmah
   • Pallab Bhattacharya

   OriginalPaper 21 February 2022 Pages: 2758 - 2775

   

9. Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway

   • Xiaoxia Yang
   • Mengxia Wang
   • Li Luo

   OriginalPaper 22 February 2022 Pages: 2776 - 2798

   

10. Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats

    • Changsheng Li
    • Sufang Liu
    • Feng Tao

    OriginalPaper 24 February 2022 Pages: 2799 - 2807

    

11. Long Non-coding RNA RMST Worsens Ischemic Stroke via MicroRNA-221-3p/PIK3R1/TGF-β Signaling Pathway

    • Jie Li
    • Ning Wang
    • Kuo Tian

    OriginalPaper 25 February 2022 Pages: 2808 - 2821

    

12. Emerging Concepts on the Role of Extracellular Vesicles and Its Cargo Contents in Glioblastoma-Microglial Crosstalk

    • Sangati Pancholi
    • Ashutosh Tripathi
    • Prakash Pillai

    ReviewPaper 25 February 2022 Pages: 2822 - 2837

    

13. Novel Exosome Biomarker Candidates for Alzheimer’s Disease Unravelled Through Mass Spectrometry Analysis

    • Tânia Soares Martins
    • Rui Marçalo
    • Ana Gabriela Henriques

    OriginalPaper Open access 25 February 2022 Pages: 2838 - 2854

    

14. Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis

    • Junnan Li
    • Wei Gao
    • Rongjuan Guo

    OriginalPaper Open access 01 March 2022 Pages: 2855 - 2873

    

15. Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation

    • Ashleigh Willis
    • Judith A. Pratt
    • Brian J. Morris

    OriginalPaper Open access 01 March 2022 Pages: 2874 - 2893

    

16. Efficacy of stem cell secretome in the treatment of traumatic brain injury: A systematic review and meta-analysis of preclinical studies

    • Suleiman Alhaji Muhammad
    • Abdullahi Yahya Abbas
    • Lawal Suleiman Bilbis

    ReviewPaper 01 March 2022 Pages: 2894 - 2909

    

17. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish

    • Evin Magner
    • Pamela Sandoval-Sanchez
    • Scott M. Taylor

    OriginalPaper 04 March 2022 Pages: 2910 - 2931

    

18. T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity

    • Mohammed Sedeeq
    • Ahmed Maklad
    • Iman Azimi

    OriginalPaper Open access 04 March 2022 Pages: 2932 - 2945

    

19. Activation of the GPX4/TLR4 Signaling Pathway Participates in the Alleviation of Selenium Yeast on Deltamethrin-Provoked Cerebrum Injury in Quails

    • Jiayi Li
    • Zhongxian Yu
    • Zhigang Zhang

    OriginalPaper 05 March 2022 Pages: 2946 - 2961

    

20. Estrogen Enhances Dendrite Spine Function and Recovers Deficits in Neuroplasticity in the prpTDP-43^A315T Mouse Model of Amyotrophic Lateral Sclerosis

    • Emily E. Handley
    • Laura A. Reale
    • Catherine A. Blizzard

    OriginalPaper Open access 06 March 2022 Pages: 2962 - 2976

    

21. Imeglimin Is Neuroprotective Against Ischemic Brain Injury in Rats—a Study Evaluating Neuroinflammation and Mitochondrial Functions

    • Gintare Zemgulyte
    • Danielius Umbrasas
    • Vilmante Borutaite

    OriginalPaper 07 March 2022 Pages: 2977 - 2991

    

22. Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity

    • Wen Wen
    • Hui Li
    • Jia Luo

    ReviewPaper 07 March 2022 Pages: 2992 - 3015

    

23. A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice

    • Noelia López-Sánchez
    • Morgan Ramón-Landreau
    • José M. Frade

    OriginalPaper Open access 07 March 2022 Pages: 3016 - 3039

    

24. Interleukin-13 Affects the Recovery Processes in a Mouse Model of Hemorrhagic Stroke with Bilateral Tibial Fracture

    • Ya’nan Yan
    • Cheng Gao
    • Luyang Tao

    OriginalPaper 08 March 2022 Pages: 3040 - 3051

    

25. Synaptic or Non-synaptic? Different Intercellular Interactions with Retinal Ganglion Cells in Optic Nerve Regeneration

    • Qi Zhang
    • Yiqing Li
    • Yehong Zhuo

    ReviewPaper Open access 09 March 2022 Pages: 3052 - 3072

    

26. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells

    • Jonathan Aow
    • Tzu-Rung Huang
    • Edward H. Koo

    OriginalPaper 09 March 2022 Pages: 3073 - 3090

    

27. Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction

    • Yu-Lin Wang
    • Chung-Ching Chio
    • Ching-Ping Chang

    OriginalPaper 09 March 2022 Pages: 3091 - 3109

    

28. Mitochondrial Quality and Quantity Control: Mitophagy Is a Potential Therapeutic Target for Ischemic Stroke

    • Meiying Song
    • Yuan Zhou
    • Xiang Fan

    ReviewPaper 09 March 2022 Pages: 3110 - 3123

    

29. Targeting iNOS Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage via Promoting Ferroptosis of M1 Microglia and Reducing Neuroinflammation

    • Wenhao Qu
    • Ying Cheng
    • Jian Zhang

    OriginalPaper 09 March 2022 Pages: 3124 - 3139

    

30. Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia

    • Zihu Tan
    • Guang Yang
    • Nan Shan

    OriginalPaper 10 March 2022 Pages: 3140 - 3158

    

31. Distinct Epileptogenic Mechanisms Associated with Seizures in Wolf-Hirschhorn Syndrome

    • Thiago Corrêa
    • Maytza Mayndra
    • Cíntia B. Santos-Rebouças

    OriginalPaper 12 March 2022 Pages: 3159 - 3169

    

32. Systems-Level Analysis of Genetic Variants Reveals Functional and Spatiotemporal Context in Treatment-resistant Schizophrenia

    • Fernanda Talarico
    • Giovany Oliveira Costa
    • Sintia Iole Belangero

    OriginalPaper 12 March 2022 Pages: 3170 - 3182

    

33. SOCE-mediated NFAT1–NOX2–NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aβ generation

    • Zhenghao Sun
    • Xuewang Li
    • Weizu Li

    Original Article 14 March 2022 Pages: 3183 - 3205

    

34. The Role of Zinc in Axon Formation via the mTORC1 Pathway

    • Seunghyuk Choi
    • Donghyeon Kang
    • Sang Won Suh

    OriginalPaper 15 March 2022 Pages: 3206 - 3217

    

35. circDlgap4 Alleviates Cerebral Ischaemic Injury by Binding to AUF1 to Suppress Oxidative Stress and Neuroinflammation

    • Huan Liu
    • Wen Zheng
    • Zhi Song

    OriginalPaper 16 March 2022 Pages: 3218 - 3232

    

36. Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts

    • Zhihui Zhu
    • Zainuddin Quadri
    • Erhard Bieberich

    OriginalPaper 16 March 2022 Pages: 3233 - 3253

    

37. Effects of Involuntary and Voluntary Exercise in Combination with Acousto-Optic Stimulation on Adult Neurogenesis in an Alzheimer's Mouse Model

    • Wan-yi Li
    • Jun-yan Gao
    • Li-ping Li

    OriginalPaper 17 March 2022 Pages: 3254 - 3279

    

38. Nicotine Activating α₄β₂ Nicotinic Acetylcholine Receptors to Suppress Neuroinflammation via JAK2-STAT3 Signaling Pathway in Ischemic Rats and Inflammatory Cells

    • Qi Wang
    • Jinyu Gou
    • Yafu Yin

    OriginalPaper 17 March 2022 Pages: 3280 - 3293

    

39. Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice

    • Ya-Nan Jiao
    • Jing-Sheng Zhang
    • Zhan-You Wang

    OriginalPaper Open access 18 March 2022 Pages: 3294 - 3309

    

40. PrP^Sc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways

    • Wei Yang
    • Cao Chen
    • Xiao-Ping Dong

    OriginalPaper 18 March 2022 Pages: 3310 - 3321