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Handbook of Stem Cell Therapy

  • Living reference work
  • © 2022

Overview

Editors:
  1. Khawaja H. Haider

    1. Department of Basic Sciences, Sulaiman AlRajhi University, Al Bukairiyah, Saudi Arabia

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  • Present the therapeutic potential of stem cells in regenerative medicine
  • Explores the clinical applications of cell-free therapy using stem cell-derived secretome cell-free
  • Reviews advances, opportunities, and challenges in stem cell-based therapy

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Table of contents (49 entries)

  1. A Multilevel Approach to the Causes of Genetic Instability in Stem Cells

    • Elio A. Prieto Gonzalez

  2. Adipose tissue-derived regenerative cell-based therapies: Current optimisation strategies for effective treatment in aesthetic surgery

    • Yusuke Shimizu, Edward Hosea Ntege, Hiroshi Sunami

  3. Advances, Opportunities, and Challenges in Stem Cell-Based Therapy

    • Renata Szydlak

  4. Augmenting Mesenchymal Stem Cell-Based Therapy of the Infarcted Myocardium with Statins

    • Sulaiman Alnasser, Mabrouk AL-Rasheedi, Mateq A. Alreshidi, Saleh F. Alqifari, Khawaja Husnain Haider

  5. Bioengineering Technique Progress of Direct Cardiac Reprogramming

    • Dingqian Liu, Khawaja Husnain Haider, Changfa Guo

  6. Common Ethical Considerations of Human-Induced Pluripotent Stem Cell Research

    • Adekunle Ebenezer Omole, Adegbenro Omotuyi John Fakoya, Kinglsey Chinonyerem Nnawuba, Khawaja Husnain Haider

  7. Considerations for Clinical Use of Mesenchymal Stromal Cells

    • Abdelkrim Hmadcha, Bernat Soria, Juan R. Tejedo, Francico J. Bedoya, Jose Miguel Sempere-Ortells, Tarik Smani

  8. Current State of Stem Cell Therapy for Heart Diseases

    • Yong Sheng Tan, Qi Hao Looi, Nadiah Sulaiman, Min Hwei Ng, Jia Xian Law

  9. Current Trends and Future Outlooks of Dental Stem-Cell-Derived Secretome/Conditioned Medium in Regenerative Medicine

    • Israa Ahmed Radwan, Dina Rady, Sara El Moshy, Marwa M. S. Abbass, Khadiga Mostafa Sadek, Aiah A. El-Rashidy et al.

  10. Direct Reprogramming Strategies for the Treatment of Nervous System Injuries and Neurodegenerative Disorders

    • Katarzyna Pieczonka, William Brett McIntyre, Mohamad Khazaei, Michael G. Fehlings

  11. Effects of 3D Cell Culture on the Cell Fate Decisions of Mesenchymal Stromal/Stem Cells

    • Darius Widera

  12. Endothelial Progenitor Cells from Bench to Antitumor Therapy and Diagnostic Imaging

    • Tiziana Annese, Roberto Tamma, Domenico Ribatti

  13. Exosome-Based Cell-Free Therapy in Regenerative Medicine for Myocardial Repair

    • Khawaja Husnain Haider, Mustapha Najimi

  14. Extracellular Vesicles Derived from Mesenchymal Stem Cells

    • M. O. Gomzikova, V. James, A. A. Rizvanov

  15. Extracellular Vesicles-Based Cell-Free Therapy for Liver Regeneration

    • Mustapha Najimi, Haider Khawaja

  16. Future Perspectives of Exosomal Payload of miRNAs in Lung Cancer

    • Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Federico Banchelli, Roberto D’Amico, Massimo Dominici et al.

  17. Glial Cells in Neuroinflammation in Various Disease States

    • Derek Barthels, Hiranmoy Das

  18. Human Mesenchymal Stem Cells: The Art to Use Them in the Treatment of Previously Untreatable

    • Jan Lakota, Maria Dubrovcakova, Khawaja Husnain Haider

  19. Human Stem Cell Differentiation In Vivo in Large Animals

    • John S. Pixley

  20. Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform for Modeling Arrhythmias

    • Lisa Lin, Tiffany Barszczewski, Patrick G. Burgon, Glen F. Tibbits
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Keywords

About this book

The handbook comprehensively reviews the therapeutic potential of stem cells and stem cell-based cell-free strategies for the treatment of diseases. The initial chapters discuss the diverse applications of the stem and progenitor cells, including skeletal myoblasts, endothelial progenitor cells, adipose tissue-derived stem cells, induced pluripotent stem cells, mesenchymal stem cells, and neuronal stem cells in myocardial repair, inflammatory bowel disease, cognitive deficits, wound healing, retinal disorders, and COVID-19. The subsequent chapter summarizes methods for identifying and characterizing mesenchymal stem cells and discusses their properties and surface markers used for their prospective isolation. It also covers the therapeutic potential of mesenchymal stem cells in regenerative medicine. In turn, the book reviews the impact of stem cells derived secretome on various biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, musculoskeletal pathologies, wound healing, anti-fibrotic, and anti-tumor for tissue maintenance and regeneration.

Lastly, it summarizes treatment advantages, opportunities, and shortcomings in stem cell-based therapy, potentially helping to refine future trials and translate them from experimental to clinical studies. This reference book is a valuable resource for researchers involved in stem cell research to understand the multifaceted therapeutic applications of stem cells.

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Editors and Affiliations

  • Department of Basic Sciences, Sulaiman AlRajhi University, Al Bukairiyah, Saudi Arabia

    Khawaja H. Haider

About the editor

Dr. Khawaja Husnain Haider is currently a Professor of Cellular and Molecular Pharmacology (Stem cells and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University.

He has also served on the editorial boards of various research journals and as an invited reviewer for several respected international journals. His research focuses on using DNA and stem cells as “drugs,” a topic that has gained popularity in regenerative medicine. He has published over 270 papers in various leading journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling, as well as abstracts, book chapters. He has also given numerous presentations and recently edited 4 books covering various facets of stem cell biology.

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Bibliographic Information

  • Book Title: Handbook of Stem Cell Therapy

  • Editors: Khawaja H. Haider

  • DOI: https://doi.org/10.1007/978-981-16-6016-0

  • Publisher: Springer Singapore

  • eBook Packages: Springer Reference Biomedicine and Life Sciences, Reference Module Biomedical and Life Sciences

  • eBook ISBN: 978-981-16-6016-0Due: 21 July 2022

  • Number of Pages: X, 1190

  • Number of Illustrations: 10 b/w illustrations, 10 illustrations in colour

  • Topics: Stem Cells, Regenerative Medicine/Tissue Engineering, Medicine/Public Health, general, Cancer Research

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