Abstract
In 2006, Shinya Yamanaka generated induced pluripotent stem cells (iPSCs), which has been the major scientific event of the decade that caught the eye of many scientists, politicians, and bioethicists. The use of human embryonic stem cells (hESCs) has previously been limited by ethical issues related to the destruction of embryos. However, with iPSCs, scientists can now reprogram virtually any human somatic cells through the expression of a combination of embryonic transcription factors to a pluripotent embryonic stem-cell-like state, thereby avoiding the contentious destruction of human embryos. Although the clinical realities of human-induced pluripotent stem cells (hiPSCs) appear very promising, they are still laden with some ethical concerns that scientists and legal authorities in the field of iPSC research must recognize. This article briefly reviews some ethical issues associated with the use of hiPSCs and suggests ways to address these challenges.
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Abbreviations
- CNV:
-
Copy number variations
- ESCs:
-
Embryonic stem cells
- FACS:
-
Fluorescence-activated cell sorting
- hESCs:
-
Human embryonic stem cells
- HFEA:
-
Human Fertilization and Embryology Authorities
- hiPSCs:
-
Human-induced pluripotent stem cells
- iPSCs:
-
Induced pluripotent stem cells
- IVF:
-
In vitro fertilization
- MACS:
-
Magnetic-activated cell sorting
- SCNT:
-
Somatic cell nuclear transfer
- SNV:
-
Single nucleotide variation
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Omole, A.E., Fakoya, A.O.J., Nnawuba, K.C., Haider, K.H. (2022). Common Ethical Considerations of Human-Induced Pluripotent Stem Cell Research. In: Haider, K.H. (eds) Handbook of Stem Cell Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-16-6016-0_21-1
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