SETD2: from chromatin modifier to multipronged regulator of the genome and beyond Thom M. MolenaarFred van Leeuwen Review Open access 06 June 2022 Article: 346
Early human trophoblast development: from morphology to function Martin GausterGerit MoserBerthold Huppertz Review Open access 05 June 2022 Article: 345
Tip-end fusion of a rod-shaped secretory organelle Johannes NaßSophia N. KoerdtVolker Gerke Original Article Open access 04 June 2022 Article: 344
HIF-1-dependent heme synthesis promotes gemcitabine resistance in human non-small cell lung cancers via enhanced ABCB6 expression Lisha XiangYongsheng WangGanfeng Xie Original Article 04 June 2022 Article: 343
Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion Ana Belén UcedaJuan FrauMiquel Adrover Original Article Open access 04 June 2022 Article: 342
HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch–Nyhan disease J. S. WitteveenS. R. LoopstokS. M. Kolk Original Article Open access 04 June 2022 Article: 341
Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells Matthias RathKonrad SchwefelUte Felbor Original Article Open access 04 June 2022 Article: 340
Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint Barbara GuerraThomas K. DoktorBrage S. Andresen Original Article Open access 04 June 2022 Article: 339
BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation Chenlu WangQiqin XuXiong Ji Original Article 04 June 2022 Article: 338
Transcription factor networks in trophoblast development Henrieta PapuchovaPaulina A. Latos Review Open access 03 June 2022 Article: 337
Brain proteome profiling implicates the complement and coagulation cascade in multiple system atrophy brain pathology Rasmus RydbirkOle ØstergaardSusana Aznar Original Article 03 June 2022 Article: 336
Integrating intracellular nanovesicles into integrin trafficking pathways and beyond Gabrielle LarocqueStephen J. Royle Review Open access 03 June 2022 Article: 335
Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice Alexandra RalevskiFederico ApeltTamas L. Horvath Original Article 02 June 2022 Article: 334
Oxidative stress response pathways in fungi Hajar YaakoubSara MinaNicolas Papon Review 01 June 2022 Article: 333
Consequences of the Hsp110DE9 mutation in tumorigenesis and the 5-fluorouracil-based chemotherapy response in Msh2-deficient mice Kathleen NoelA.’dem BokhariAda Collura Original Article 01 June 2022 Article: 332
Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer’s disease neuropathology Sudhanshu AgrawalJanet E. BaulchAnshu Agrawal Original Article Open access 01 June 2022 Article: 331
Trigeminal neurons control immune-bone cell interaction and metabolism in apical periodontitis Obadah N. AustahKatherine V. LillisAnibal Diogenes Original Article Open access 31 May 2022 Article: 330
Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes Annika BubSantra BrennaBerta Puig Original Article Open access 31 May 2022 Article: 329
ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells Cui ZhangShali WuMengrui Wu Original Article 31 May 2022 Article: 328
Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology Olivier LuretteHala GuedouariEtienne Hebert-Chatelain Original Article Open access 30 May 2022 Article: 327
Complementary omics strategies to dissect p53 signaling networks under nutrient stress Markus GalhuberHelene MichenthalerAndreas Prokesch Original Article Open access 30 May 2022 Article: 326
Neuroendocrinal and molecular basis of flight performance in locusts Li HouSiyuan GuoXianhui Wang Review 30 May 2022 Article: 325
A novel sterol-binding protein reveals heterogeneous cholesterol distribution in neurite outgrowth and in late endosomes/lysosomes Akiko Yamaji-HasegawaMotohide MurateToshihide Kobayashi Original Article 29 May 2022 Article: 324
PAI-1 production by reactive astrocytes drives tissue dysfibrinolysis in multiple sclerosis models Héloïse LebasSylvaine GuéritIsabelle Bardou Original Article 28 May 2022 Article: 323
In vivo impact of JAK3 A573V mutation revealed using zebrafish Faiza BasheerVilasha BulleerazAlister C. Ward Original Article Open access 27 May 2022 Article: 322
Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism Mathias VanmunsterAna Victoria Rojo GarciaFrank Suhr Original Article 27 May 2022 Article: 321
Discovery of surface biomarkers for cell mechanophenotype via an intracellular protein-based enrichment strategy Megan E. DempseyGraylen R. ChickeringEric M. Darling Original Article 27 May 2022 Article: 320
PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα Xinping HuangYongfeng YangXiaofeng Zheng Original Article 27 May 2022 Article: 319
Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks Petra HonzlováZuzana NovosadováAlena Sumová Original Article 27 May 2022 Article: 318
Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta Marta Z. PaciaNatalia ChorazyStefan Chlopicki Original Article Open access 27 May 2022 Article: 317
Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation Agata PoświataKamila KozikDaria Zdżalik-Bielecka Original Article Open access 27 May 2022 Article: 316
Dead Cas(t) light on new life: CRISPRa-mediated reprogramming of somatic cells into neurons Meiling ZhouYu CaoBin Zhang Review 24 May 2022 Article: 315
Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation Rong-Mo ZhangKerstin TiedemannDieter P. Reinhardt Original Article 23 May 2022 Article: 314
Mechanisms involved in controlling RNA virus-induced intestinal inflammation Evan ZhangMingli FangZhiqiang Zhang Review 23 May 2022 Article: 313
In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1 May MeltzerNoam EliashNiv Papo Original Article 23 May 2022 Article: 312
Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway Yang ZhengYunqi LiJian Wu Original Article Open access 22 May 2022 Article: 311
The HLA-G immune checkpoint: a new immuno-stimulatory role for the α1-domain-deleted isoform Diana Tronik-Le RouxMarina DaouyaEdgardo D. Carosella Original Article 21 May 2022 Article: 310
Role of LL-37 in thrombotic complications in patients with COVID-19 Zilei DuanJuan ZhangRen Lai Original Article Open access 21 May 2022 Article: 309
Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation Drishti TiwariNancy AhujaPawan Gupta Original Article 21 May 2022 Article: 308
Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome-like exocrinopathy Akiko SuzukiChihiro IwayaJunichi Iwata Original Article 20 May 2022 Article: 307
Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer Na-Lee KaGa Young LimMi-Ock Lee Original Article Open access 20 May 2022 Article: 306
The novel P330L pathogenic variant of aromatic amino acid decarboxylase maps on the catalytic flexible loop underlying its crucial role Giovanni BiselloKatarzyna KusmierskaMariarita Bertoldi Original Article Open access 20 May 2022 Article: 305
Regulation of choroid plexus development and its functions Petra KompaníkováVítězslav Bryja Review Open access 19 May 2022 Article: 304
Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway Ying CaoWeili MaiLiuluan Zhu Original Article 19 May 2022 Article: 303
Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice Negah AhmadvandArun LingampallySaverio Bellusci Original Article Open access 19 May 2022 Article: 302
Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming Sadiq UmarKarol PalasiewiczShiva Shahrara Original Article 19 May 2022 Article: 301
Therapeutic potential of a single-dose melatonin in the attenuation of cardiac ischemia/reperfusion injury in prediabetic obese rats Kodchanan SinghanatNattayaporn ApaijaiNipon Chattipakorn Original Article 19 May 2022 Article: 300
The limited role of most circRNAs as sponges for microRNAs Ye-Zhao Wang Commentary 19 May 2022 Article: 299
Major depression favors the expansion of Th17-like cells and decrease the proportion of CD39+Treg cell subsets in response to myelin antigen in multiple sclerosis patients Priscila Mendonça do SacramentoMarisa SalesCleonice Alves de Melo Bento Original Article 18 May 2022 Article: 298
SIRT7 in the aging process Francisco Alejandro Lagunas-Rangel Review Open access 18 May 2022 Article: 297
