1. Type I interferon-mediated tumor immunity and its role in immunotherapy

   • Renren Yu
   • Bo Zhu
   • Degao Chen

   Review Open access 16 March 2022 Article: 191

   

2. Platelet-released extracellular vesicles: the effects of thrombin activation

   • Rosa Suades
   • Teresa Padró
   • Lina Badimon

   Original Article 14 March 2022 Article: 190

   

3. Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes

   • Mafalda Rizzuti
   • Valentina Melzi
   • Stefania Corti

   Original Article Open access 14 March 2022 Article: 189

   

4. Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression

   • Dick R. Nässel
   • Shun-Fan Wu

   Review Open access 14 March 2022 Article: 188

   

5. Hematopoietic responses to SARS-CoV-2 infection

   • Shokrollah Elahi

   Review Open access 13 March 2022 Article: 187

   

6. TAZ promotes PDX1-mediated insulinogenesis

   • Mi Gyeong Jeong
   • Hyo Kyeong Kim
   • Eun Sook Hwang

   Original Article 13 March 2022 Article: 186

   

7. N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion

   • Laura Hobohm
   • Tomas Koudelka
   • Matthias Voss

   Original Article Open access 13 March 2022 Article: 185

   

8. S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α

   • Yifei Sun
   • Ya Fan
   • Xiubin Liang

   Original Article Open access 12 March 2022 Article: 184

   

9. Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases

   • Ranchana Yeewa
   • Pawita Chaiya
   • Luca Lo Piccolo

   Review 12 March 2022 Article: 183

   

10. Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators?

    • Melodie Migault
    • Sunil Sapkota
    • Cameron P. Bracken

    Review Open access 12 March 2022 Article: 182

    

11. Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma

    • Sojin Kim
    • Soo-Ji Park
    • Chul‑Kee Park

    Original Article Open access 12 March 2022 Article: 181

    

12. Disrupted mossy fiber connections from defective embryonic neurogenesis contribute to SOX11-associated schizophrenia

    • Xianmixinuer Abulaiti
    • Aifang Wang
    • Lingsong Li

    Original Article 07 March 2022 Article: 180

    

13. ATP synthase F_OF₁ structure, function, and structure-based drug design

    • Alexey V. Vlasov
    • Stepan D. Osipov
    • Valentin I. Gordeliy

    Review 06 March 2022 Article: 179

    

14. Met–HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells

    • Yaakov E. Stern
    • Abdulhameed Al-Ghabkari
    • Morag Park

    Original Article Open access 05 March 2022 Article: 178

    

15. Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact

    • Francesca Velarde
    • Sarah Ezquerra
    • Maroun Khoury

    Review 05 March 2022 Article: 177

    

16. RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control

    • Harihar Milaganur Mohan
    • Hanna Trzeciakiewicz
    • Lisa M. Sharkey

    Original Article 05 March 2022 Article: 176

    

17. FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin

    • Bin Qiu
    • Zhaohui Zhong
    • Weidong Yong

    Original Article 04 March 2022 Article: 175

    

18. Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies

    • Roberta Cascella
    • Alessandra Bigi
    • Cristina Cecchi

    Review Open access 04 March 2022 Article: 174

    

19. An imbalance of the IL-33/ST2-AXL-efferocytosis axis induces pregnancy loss through metabolic reprogramming of decidual macrophages

    • Yan‑Ran Sheng
    • Wen‑Ting Hu
    • Xiao‑Yong Zhu

    Original Article 04 March 2022 Article: 173

    

20. Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease

    • Angela Godinez
    • Rashi Rajput
    • Vivek Gupta

    Review Open access 04 March 2022 Article: 172

    

21. Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens

    • Annika Nelde
    • Lea Flötotto
    • Klaus Wethmar

    Original Article Open access 03 March 2022 Article: 171

    

22. MicroRNA-24-3p promotes skeletal muscle differentiation and regeneration by regulating HMGA1

    • Paromita Dey
    • Miles A. Soyer
    • Bijan K. Dey

    Original Article 03 March 2022 Article: 170

    

23. “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin

    • Xi Chen
    • Jing Dong
    • Hong Jiang

    Review 03 March 2022 Article: 169

    

24. Meprin β knockout reduces brain Aβ levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer’s disease

    • Liana Marengo
    • Fred Armbrust
    • Claus U. Pietrzik

    Original Article Open access 02 March 2022 Article: 168

    

25. Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca²⁺-induced proteostasis disease stress

    • Ben B. Wang
    • Haijin Xu
    • Pirjo M. Apaja

    Original Article Open access 01 March 2022 Article: 167

    

26. XPG: a multitasking genome caretaker

    • Alba Muniesa-Vargas
    • Arjan F. Theil
    • Hannes Lans

    Review Open access 01 March 2022 Article: 166

    

27. PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis

    • Yolanda Moyano-Rodríguez
    • David Vaquero
    • Ethel Queralt

    Original Article Open access 01 March 2022 Article: 165

    

28. MCL1 alternative polyadenylation is essential for cell survival and mitochondria morphology

    • Isabel Pereira-Castro
    • Beatriz C. Garcia
    • Alexandra Moreira

    Original Article 01 March 2022 Article: 164

    

29. Current insights into the role of Fli-1 in hematopoiesis and malignant transformation

    • Yaacov Ben-David
    • Babu Gajendran
    • Eldad Zacksenhaus

    Review 28 February 2022 Article: 163

    

30. The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

    • Swati Mishra
    • Allison Knupp
    • Jessica E. Young

    Original Article Open access 28 February 2022 Article: 162

    

31. SARM1 can be a potential therapeutic target for spinal cord injury

    • Qicheng Lu
    • Benson O. A. Botchway
    • Xuehong Liu

    Review 28 February 2022 Article: 161

    

32. Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease

    • Nelma M. Palminha
    • Cleide Dos Santos Souza
    • Sherif F. El-Khamisy

    Original Article Open access 28 February 2022 Article: 160

    

33. Multiple cell populations generate macrophage progenitors in the early yolk sac

    • Chie Ito
    • Mari Hikosaka-Kuniishi
    • Toshiyuki Yamane

    Original Article 27 February 2022 Article: 159

    

34. Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development

    • Junguang Liao
    • Yuping Huang
    • Guiqian Chen

    Review 27 February 2022 Article: 158

    

35. Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades

    • Mariliis Klaas
    • Kristina Mäemets-Allas
    • Viljar Jaks

    Original Article Open access 26 February 2022 Article: 157

    

36. Cell adhesion tunes inflammatory TPL2 kinase signal transduction

    • Maria Vougioukalaki
    • Konstantina Georgila
    • Aristides G. Eliopoulos

    Original Article 26 February 2022 Article: 156

    

37. ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation

    • Hyun-Jung Kim
    • Woo-Jin Kim
    • Hyun-Mo Ryoo

    Original Article Open access 26 February 2022 Article: 155

    

38. Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth

    • Pei Jiang
    • Xiangyu Ma
    • Renjie Chai

    Original Article 26 February 2022 Article: 154

    

39. Organoids from human tooth showing epithelial stemness phenotype and differentiation potential

    • Lara Hemeryck
    • Florian Hermans
    • Hugo Vankelecom

    Original Article Open access 26 February 2022 Article: 153

    

40. CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity

    • Karolina Losenkova
    • Akira Takeda
    • Gennady G. Yegutkin

    Original Article Open access 25 February 2022 Article: 152

    

41. PACS2–TRPV1 axis is required for ER–mitochondrial tethering during ER stress and lung fibrosis

    • Jessica Knoell
    • Shashi Chillappagari
    • Poornima Mahavadi

    Original Article Open access 25 February 2022 Article: 151

    

42. Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation

    • Laura Di Patria
    • Giosuè Annibalini
    • Elena Barbieri

    Original Article Open access 24 February 2022 Article: 150

    

43. Monitoring the maturation of the sarcomere network: a super-resolution microscopy-based approach

    • Anna Skorska
    • Lisa Johann
    • Heiko Lemcke

    Original Article Open access 23 February 2022 Article: 149

    

44. Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model

    • Jacqueline Kajtna
    • Stephen H. Tsang
    • Susanne F. Koch

    Original Article Open access 23 February 2022 Article: 148

    

45. Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis

    • Ng Desi
    • Qing Yun Tong
    • Yvonne Tay

    Original Article 23 February 2022 Article: 147

    

46. MicroRNA-22 promoted osteogenic differentiation of valvular interstitial cells by inhibiting CAB39 expression during aortic valve calcification

    • Fan Yang
    • Suxuan Liu
    • Guokun Wang

    Original Article 21 February 2022 Article: 146

    

47. FVIII regulates the molecular profile of endothelial cells: functional impact on the blood barrier and macrophage behavior

    • Marie Cadé
    • Javier Muñoz-Garcia
    • Dominique Heymann

    Original Article 21 February 2022 Article: 145

    

48. Defective perlecan-associated basement membrane regeneration and altered modulation of transforming growth factor beta in corneal fibrosis

    • Steven E. Wilson

    Review 21 February 2022 Article: 144

    

49. Melatonin: highlighting its use as a potential treatment for SARS-CoV-2 infection

    • Russel J. Reiter
    • Ramaswamy Sharma
    • Daniel P. Cardinali

    Review Open access 20 February 2022 Article: 143

    

50. Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications

    • Lijun Chen
    • Jingjing Qu
    • Charlie Xiang

    Review 20 February 2022 Article: 142