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Part of the book series: Virology Monographs / Die Virusforschung in Einzeldarstellungen ((VIROLOGY,volume 8))

Abstract

When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units (“cell culture”), the original cell population undergoes a large variety of modifications. Only a minority of the cells will thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one of only a few recognizably different cell types. With most organs fibroblast-like cells survive longest and outgrow other types. This is then a stable state of affairs for many generations. This treatise will not discuss whether this simplification and stabilization represents selection of certain pre-existing cell types or a modification of cells into only a few recognizably different categories; for an excellent review see Harris (1964).

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Pontén, J. (1971). Spontaneous and Virus Induced Transformation in Cell Culture. In: Spontaneous and Virus Induced Transformation in Cell Culture. Virology Monographs / Die Virusforschung in Einzeldarstellungen, vol 8. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8258-1_1

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