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Toxic Substances and Human Risk

Principles of Data Interpretation

  • Robert G. Tardiff
  • Joseph V. Rodricks

Part of the Life Science Monographs book series (LSMO)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Historical Perspectives and General Concepts

    1. Front Matter
      Pages 1-1
    2. John Doull
      Pages 3-12
    3. Jeannee K. Yermakoff
      Pages 13-27
    4. Rolf Hartung
      Pages 29-46
    5. Gary P. Carlson
      Pages 47-76
    6. David W. Gaylor
      Pages 77-91
  3. Interpretation of Information from Human Studies

    1. Front Matter
      Pages 93-93
    2. James E. Cone, Gordon R. Reeve, Philip J. Landrigan
      Pages 95-120
    3. David G. Hoel, Philip J. Landrigan
      Pages 121-130
  4. Interpretation of in Vivo Experimental Data for Evaluation of Hazards to Humans

    1. Front Matter
      Pages 131-131
    2. Edward R. Garrett
      Pages 153-235
    3. Charles C. Brown
      Pages 237-268
    4. Edward J. Calabrese
      Pages 269-280
    5. James R. Withey
      Pages 281-299
    6. Larry S. Andrews, Stephen L. Longacre, Robert Snyder
      Pages 301-316
    7. Kurt Enslein
      Pages 317-336
  5. Interpretation of in Vitro Experimental Data for Evaluation of Hazards to Humans

    1. Front Matter
      Pages 337-337
    2. Ronald W. Hart, David Brusick
      Pages 339-355
    3. James R. Gillette, Ronald W. Estabrook
      Pages 357-374
  6. Risk Analysis

    1. Front Matter
      Pages 375-375
    2. Stephen L. Brown
      Pages 377-390
    3. Robert G. Tardiff, Joseph V. Rodricks
      Pages 391-434
  7. Back Matter
    Pages 435-445

About this book

Introduction

As society has become increasingly aware of the potential threats to human health due to exposures to toxic chemicals in the environment and the workplace and in consumer products, it has placed increased demands upon the still-fledgling science of toxicology. As is often the case when science is called upon to supply firm answers when pertinent information and fundamental knowledge are lack­ ing, both the scientific and the social issues become confused and new tensions develop. One of the major purposes of this book is to focus on those aspects of the science of toxicology that pertain most to social issues-namely, analysis of risk for purposes of human health protection. Although it is apparent that the discipline of toxicology is not yet prepared to provide firm answers to many questions concerning human risk, it is important that the rigorously derived information be used in the most objective and logical way to yield the closest approximation to the truth. This book is designed to sup­ ply as much guidance for such tasks as is permitted by the current state of our knowledge. Its emphasis is thus placed on interpretation of toxicity data (broadly defined) for assessing risks to human health. In this way, it differs from other basic toxicology texts, most of which emphasize methods for performing studies or describe various toxicological endpoints and classes of toxic agents.

Keywords

chemicals design environment health information iron protection risk risk analysis risk assessment science toxicology

Editors and affiliations

  • Robert G. Tardiff
    • 1
  • Joseph V. Rodricks
    • 1
  1. 1.Environ CorporationUSA

Bibliographic information