Extrapolation from Animal Data
It is the premise of this chapter that there is a biological basis upon which toxicologists may be able to extrapolate from animals to humans. Its foundation lies in evolutionary theory, with the phylogenetic continuity of animal species.
KeywordsSickle Cell Disease Quantitative Risk Assessment Predictive Toxicology Glutathione Peroxidase Level Biological Regularity
Unable to display preview. Download preview PDF.
- Calabrese, E. J. 1983. Principles of Animal Extrapolation. Wiley, New York.Google Scholar
- Dickes, S. E. 1970. Pp. 16’30 in Mechanisms of Urine Concentration and Dilution in Mammals. Edward Arnold, London.Google Scholar
- Freireich, E. J., E. A. Gehan, D. P. Rall, L. H. Schmidt, and H. E. Skipper. 1966. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother. Rep. 50:219–244.Google Scholar
- Goldsmith, M. A., M. Slavik, and S. K. Carter. 1975. Quantitative prediction of drug toxicity in humans from toxicology in small and large animals. Cancer Res. 35:1354–1364.Google Scholar
- Maronpot, R. R. 1972. Erythrocyte glucose-6-phosphate dehydrogenase and glutathione deficiency in sheep. Can. J. Comp. Med. 36:55–60.Google Scholar
- Pinkel, D. 1958. The use of body surface area as a criterion of drug dosage in cancer chemotherapy. Cancer Res. 18:853–856.Google Scholar
- Weiss, M, W. Sziegoleit, and W. Förster. 1977. Dependence of pharmacokinetic parameters on the body weight. Int. J. Clin. Pharmacol. Biopharm. 15:572–575.Google Scholar