Factors Modifying Toxicity

  • Gary P. Carlson
Part of the Life Science Monographs book series (LSMO)


In the evaluation of hazards associated with exposure of humans to chemicals, whether they be encountered as drugs, through occupational exposure, or as the result of environmental contamination, the use of animal data is of obvious importance. In the usual safety evaluation studies of a compound in laboratory animals, environmental conditions are controlled as carefully as possible, animal bedding and food are selected with great diligence, and the utmost care is taken to maintain the health of the animals in order to minimize confounding variables. In order to institute the proper controls, one must first recognize the factors that affect the responses of animals to exposures to toxic chemicals. Some of these are discussed in this chapter.


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© Plenum Press, New York 1987

Authors and Affiliations

  • Gary P. Carlson
    • 1
  1. 1.Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal SciencePurdue UniversityWest LafayetteUSA

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