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Biotechnological Approaches for the Production of Immunomodulating Phytomolecules

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Plants and Phytomolecules for Immunomodulation

Abstract

Immunomodulating molecules can alter the immune response either by immunostimulation or immunosuppression. Manipulation of the immune system is commonly practiced in the case of destructive diseases mediated by uncontrolled immune responses. The use of chemical drugs as immunomodulators has several limitations, such as a higher risk of opportunistic infection and an adverse effect on the overall immune system. To address this issue, plenty of plant-derived molecules, like alkaloids, flavonoids, saponins, terpenoids, and steroid glycosides, have been utilized to manipulate the human immune system. Many traditional medicinal systems, including Ayurveda in India, have been employing phytomolecules as immunomodulators to control immunological disorders and strengthen the host immune system against many infectious diseases. Recent advances in biotechnological techniques offer tools for the genetic manipulation and metabolic engineering of biosynthetic pathways not only in plants but also in microorganisms. Therefore, it is also overviewed the use of yeasts for enhancing the production of phytomolecules in an easy-to-handle system. This chapter highlights the available information on the development of biotechnological tools to improve the accumulation of the desired natural compounds in controlled conditions. The major issues faced during the development of these biotechniques for the production of valuable phytomolecules are also addressed in this chapter.

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Authors and Affiliations

  1. Linking Landscape, Environment, Agriculture and Food (LEAF), Instituto Superior de Agronomia, Universidade de Lisboa, Lisbon, Portugal

    Farzana Sabir

  2. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal

    Farzana Sabir

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  1. Farzana Sabir
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Editors and Affiliations

  1. Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India

    Neelam S. Sangwan

  2. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    Mohamed A. Farag

  3. Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Belo Horizonte, Brazil

    Luzia Valentina Modolo

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Sabir, F. (2022). Biotechnological Approaches for the Production of Immunomodulating Phytomolecules. In: Sangwan, N.S., Farag, M.A., Modolo, L.V. (eds) Plants and Phytomolecules for Immunomodulation. Springer, Singapore. https://doi.org/10.1007/978-981-16-8117-2_17

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