Development of novel chalcone derivatives as multifunctional agents for the treatment of Alzheimer’s disease Xinjuan LiYuting LiZhipei Sang Original Research Article 26 February 2024 Pages: 548 - 561
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus Clementina M. M. SantosCarina ProençaEduarda Fernandes Original Research Article Open access 24 February 2024 Pages: 600 - 610
Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers Qionghui PanHuamao YangFaqing Ye Original Research Article 19 February 2024 Pages: 532 - 547
Synthesis and pharmacological activities of Schiff bases with some transition metal complexes: a review Kibrom MezgebeEndale Mulugeta Review Article 19 February 2024 Pages: 439 - 463
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements Abeer F. R. AlanaziShozeb HaiderGary N. Parkinson Brief Report 19 February 2024
Targeting disease with benzoxazoles: a comprehensive review of recent developments Abdulrahman AbdullahiKeng Yoon Yeong Review Article Open access 18 February 2024 Pages: 406 - 438
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics Miriam GirardiniDiana MachadoMarco Pieroni Original Research Article 17 February 2024 Pages: 518 - 531
Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives Saraswati PatelSonika JainJaya Dwivedi Review Article 17 February 2024 Pages: 370 - 405
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro Xuan WangSumeng GuanMoran Sun Original Research Article 15 February 2024 Pages: 504 - 517
Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase Lucia KováčikováSunil GaikwadMilan Štefek Original Research Article Open access 14 February 2024 Pages: 492 - 503
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship Mohamed A. ElsayedAlshaimaa M. ElsayedFarid M. Sroor Original Research Article Open access 14 February 2024 Pages: 476 - 491
Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3 Alexandrina S. VolobuevaAnton A. ShetnevSergey V. Baykov Original Research Article 13 February 2024 Pages: 464 - 475
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis Diego Eidy ChibaGuilherme Felipe dos Santos FernandesCauê Benito Scarim Review Article 02 February 2024 Pages: 354 - 369
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications Neha V. BhilareRushikesh ShedgeAjinkya More Review Article 29 January 2024 Pages: 337 - 353
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1 Aldar A. MunkuevAlexandra L. ZakharenkoOlga I. Lavrik Original Research Article 12 January 2024 Pages: 324 - 335
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48 Wenhui ChengYuejuan ZhangYi Wan Original Research Article 10 January 2024 Pages: 314 - 323
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity Qianqian CaoZhixuan WangChunhong Dong Review Article 10 January 2024 Pages: 254 - 267
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation Lijuan ZhangJian MaRuvishika S. Jayawardena Original Research Article 04 January 2024 Pages: 308 - 313
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile Asuka Joy TobuseChristine Shing Wei LawKeng Yoon Yeong Original Research Article 30 December 2023 Pages: 298 - 307
Research progress on the mechanism of anti-myocardial infarction effect and clinical application of effective components of Salvia miltiorrhiza Xin ZhangZhiying BianYuhong Liu Review Article 30 December 2023 Pages: 239 - 253
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands Benjamin E. BlassRong GaoDaniel J. Canney Original Research Article 29 December 2023 Pages: 287 - 297
Synthesis and pharmacological evaluation of novel coumarin based triazolyl glycoconjugates as potential antibacterial and anti-proliferative agents Surendra JatavRanjit SinghBhuwan B. Mishra Original Research Article 28 December 2023 Pages: 276 - 286
Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties Gabriel A. GonzalezJavier Hernandez-OrtegaJuan C. Noveron Original Research Article 23 December 2023 Pages: 268 - 275
Bioactivities and the structural modification of Parthenolide: a review Jie WuXiaoqian WangPing Gong Review Article 23 December 2023 Pages: 221 - 238
A concise review on anti-breast cancer effectiveness of s-triazines through EGFR kinase inhibition Pooja TandelRachana UpadhyayAmit B. Patel Review Article 21 December 2023 Pages: 47 - 65
Design, synthesis and evaluation of aurone and indanone derivatives as novel antitumor agents Baoxing XieGulmira TurduHaji Akber Aisa Original Research Article 20 December 2023 Pages: 201 - 220
Design, synthesis, molecular docking, and biological activity of pyrazolo[3,4-b]pyridines as promising lead candidates against Mycobacterium tuberculosis H. Surya Prakash RaoR. GunasundariJayaraman Muthukumaran Original Research Article 19 December 2023 Pages: 177 - 200
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments Hadi ObajiAbbas G. ShilabinMohamed A. Ibrahim Review Article 18 December 2023 Pages: 36 - 46
Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase Chezélle StearAnél PetzerJacobus P. Petzer Original Research Article Open access 15 December 2023 Pages: 164 - 176
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold Yuri A. PivenVeronica G. ZinovichFedor A. Lakhvich Original Research Article 11 December 2023 Pages: 151 - 163
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation Smita JainSwapnil SharmaJaiprakash Sharma Original Research Article 09 December 2023 Pages: 136 - 150
FTase inhibitors and cancer: prospects for use in targeted therapies Ming-tao XiaLing YuShuai Li Review Article 09 December 2023 Pages: 21 - 35
Enantioselectivity of pinene against Leishmania amazonensis Ingrid S. AdãoAndreza R. GarciaIgor A. Rodrigues Original Research Article 25 November 2023 Pages: 127 - 135
One-pot synthesis and in vitro bioactivity of novel 4-aminopyrazolo[3,4-b]pyridine derivatives as potential antimicrobial compounds Ranjana AggarwalSuresh KumarDeepansh Sharma Original Research Article 23 November 2023 Pages: 117 - 126
Characterization of novel angiotensin-I converting enzyme inhibitory peptides derived from Taiwan red quinoa (Chenopodium formosanum Koidz.) seed proteins using two sequential bioassay-guided fractionations Dininurilmi Putri SulemanChristoper Caesar Yudho SutopoJue-Liang Hsu Original Research Article 23 November 2023 Pages: 107 - 116
Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics Chu Anh VanDau Xuan DucNinh The Son Review Article 21 November 2023 Pages: 1 - 20
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants Walaa Hamada Abd-AllahMohamed Samir Abd El-MaksoudRasha Mohamed Hassan Original Research Article Open access 15 November 2023 Pages: 89 - 106
Design, synthesis and antimicrobial activities of 1,2,3-triazole hybrids with amine-ester functionality Jyoti SangwanC. P. KaushikManisha Chahal Original Research Article 04 November 2023 Pages: 77 - 88
Design, synthesis, and in silico studies of novel di-(2-aryl hydrozonopropanal) arene derivatives as potent anticancer for targeting A2AR and LRP6 in HCT116 cell Tahani BakhshTamer S. SalehKhadijah M. Al-Zaydi Original Research Article 03 November 2023 Pages: 66 - 76
Discovery of potent maternal embryonic leucine zipper kinase (MELK) inhibitors of novel chemotypes using structure-based pharmacophores Safa DaoudShada J. AlabedMutasem O. Taha Original Research Article 28 October 2023 Pages: 2574 - 2586
Screening of small molecule compounds targeting hnRNPA2 protein Yuan-Rong ZhengChao-Jie WangSong-Lin Shi Original Research Article 28 October 2023 Pages: 2562 - 2573
Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine F. BavoS. KickingerB. Frølund Correction Open access 26 October 2023 Pages: 2587 - 2587
Novel aloe emodin–hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways Xing LongPeilin YangWei Tian Original Research Article 19 October 2023 Pages: 2549 - 2561
The trimethoxyphenyl (TMP) functional group: a versatile pharmacophore Mohammad Amin LangarizadehAlieh AmeriHamid Forootanfar Review Article 16 October 2023 Pages: 2473 - 2500
Synthesis of 6,6-Dimethyl-3-azabicyclo [3.1.0]hexane via Ru (II)-catalyzed intramolecular cyclopropanation Yu LiYujie MaYu Zhao Brief Report 14 October 2023 Pages: 2501 - 2504
1,2,3-triazole derivatives as antiviral agents Naima Agouram Review Article 09 October 2023 Pages: 2458 - 2472
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands Liezel GouwsHelena D. Janse van RensburgMietha M. Van der Walt Original Research Article Open access 05 October 2023 Pages: 2535 - 2548
Current progress toward synthetic routes and medicinal significance of quinoline Wesam S. ShehabMostafa M. K. AmerMagda H. Abdellattif Review Article Open access 28 September 2023 Pages: 2443 - 2457
New indolo-β-lactam hybrids as potential anticancer and anti-inflammatory agents Saeedeh GhaffariAliasghar JarrahpourEdward Turos Original Research Article 25 September 2023 Pages: 2516 - 2534
Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa Emma MaldonadoAreli MinerosMahinda Martínez Original Research Article Open access 25 September 2023 Pages: 2505 - 2515
