Skip to main content
SpringerLink
Log in

Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards

  • Book
  • © 1989

Overview

Authors:
  1. K. S. Khera

    1. Health Protection Branch, Health and Welfare Canada, Ottawa, Canada

    View author publications

    You can also search for this author in PubMed   Google Scholar

  2. H. C. Grice

    1. Nepean, Canada

    View author publications

    You can also search for this author in PubMed   Google Scholar

  3. D. J. Clegg

    1. Health Protection Branch, Health and Welfare Canada, Ottawa, Canada

    View author publications

    You can also search for this author in PubMed   Google Scholar

Part of the book series: Current Issues in Toxicology (CI TOXICOLOGY)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 16.99 USD 84.99
Discount applied Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (10 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Introduction

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 1-4

  3. Terminology and Definitions

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 5-7

  4. Teratogenicity (Embryotoxicity) Studies: Design, Conduct, and Evaluation

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 9-20

  5. Multigeneration Studies

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 21-40

  6. Behavioral-Functional Teratology

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 41-58

  7. In Vitro Developmental Toxicity Assays

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 59-68

  8. Statistical Methods for Developmental Toxicity Studies

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 69-80

  9. Epidemiology

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 81-90

  10. Extrapolation of Reproductive Risks From Animal and Human Data

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 91-113

  11. Guidelines for Reproductive Toxicity Tests in Different Countries With a Proposal for International Harmonization

    • K. S. Khera, H. C. Grice, D. J. Clegg
    Pages 115-133
Back to top

Keywords

About this book

The International Life Sciences Institute (!LSI) is a scientific foundation that addresses critical health and safety issues of national and international con­ cern. ILSI promotes international cooperation by providing the mechanism for scientists from government, industry, and universities to work together on cooperative programs to generate and disseminate scientific data. The mem­ bers and trustees of the institute believe that questions regarding health and safety are best resolved when scientists can examine and discuss issues as an independent body separate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refine­ ment of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have mainly been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results to humans. Publicity surrounding toxicologic issues makes it difficult for governments to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government, and industry with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.

Authors and Affiliations

  • Health Protection Branch, Health and Welfare Canada, Ottawa, Canada

    K. S. Khera, D. J. Clegg

  • Nepean, Canada

    H. C. Grice

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation