• K. S. Khera
  • H. C. Grice
  • D. J. Clegg
Part of the Current Issues in Toxicology book series (CI TOXICOLOGY)


Over the last 25 years the number of women employed outside the home has risen dramatically in many countries. For example, in Canada the number has risen from 1 8 million in 1962 (29% of all women 15 years of age and older) to 4.9 million (52%) in 1982 (Statistics Canada, 1983). This increased participation rate—the number of women in the labor force as a percentage of all women in the population— has been mirrored by a trend for women to continue working for a greater proportion of their pregnancies. A recent survey (Statistics Canada, 1982) estimated that in 1981, 150,000 women were absent from work for two or more weeks during the year because of pregnancy. Although this number is only an approximation of the total number of women in the labor force who were pregnant during that year, it is an indication of the large number of pregnancies potentially at risk from the occupational environment.


Spontaneous Abortion Rubella Virus Occupational Environment Etiologic Study Organochlorine Insecticide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Axelson, O., Edling, C., and Andersson, L. (1983) Pregnancy outcome among women in a Swedish rubber plant. Scand. J. Work Environ. Health 9 (suppl. 2): 79–83.PubMedGoogle Scholar
  2. Barlow, S.M., and Sullivan, F.M. (1982) Reproductive Hazards of Industrial Chemicals: An Evaluation of Animal and Human Data, Academic Press, London.Google Scholar
  3. Bercovici, B., Wassermann, M., Cucos, S., Ron, M., Wassermann, D., and Pines, A. (1983) Serum levels of polychlorinated biphenyls and some organochlorinated insecticides in women with recent and former missed abortions. Environ. Res. 28: 169–174.CrossRefGoogle Scholar
  4. Blomgvist, U., Ericson, A., Kallen, B., and Westerholm, P. (1981) Delivery outcome for women working in the pulp and paper industry. Scand. J. Work Environ. Health 7: 114–118.CrossRefGoogle Scholar
  5. Bross, I.D.J. (1979) Right answers from wrong assumptions. Prey. Med. 5:203–206, editorial.Google Scholar
  6. Carmelli, D., Hofherr, J., Tomsic J., and Morgan, R.W. (1981) A Case-Control Study of the Relationship between Exposure to 2,4-D and Spontaneous Abortions in Humans,SRI International.Google Scholar
  7. Edmonds, L., Shrout, P., Hatch, N., Stein, Z., Holmes, L., Warburton, D., Klein, J., Weinstock, M., Letz, G., Whorton, R., Levin, B., Wyrocek, A., and Miller, R. (1981) Guidelines for reproductive studies in exposed human populations. In Guidelines for Studies of Human Populations Exposed to Mutagenic and Reproductive Hazards ( A.D. Bloom, Ed.), pp. 39–110, March of Dimes Birth Defects Foundation, White Plains, New York.Google Scholar
  8. Fahim, M.S., Fahim, Z., and Hall, D.G. (1976) Effects of subtoxic lead levels on pregnant women in the state of Missouri. Res. Commun. Chem. Pathol. Pharmacol. 13: 309–331.PubMedGoogle Scholar
  9. Gill, W.B., Schumacher, G.F.B., and Bibo, M. (1977) Pathological semen and anatomical abnormalities of the genital tract in human male subjects exposed to diethylstilbestrol in utero. J. Urol. 117: 477–480.PubMedGoogle Scholar
  10. Heinonen, O.P. (1986) Spontaneous abortions, stillbirths and birth defects in epidemiological search for risk indicators. In New Concepts and Developments in Toxicology ( P.L. Chambers, P. Gehring, and F. Saki, Eds.), pp. 63–76, Elsevier Science Publishers, New York.Google Scholar
  11. Hemminki, K., Franssila, E., and Vainio, H. (1980) Spontaneous abortions among female chemical workers in Finland. Int. Arch. Occup. Environ. Health 45: 123–126.PubMedCrossRefGoogle Scholar
  12. Hemminki, K., Mutanen, P., Saloniemi, I., Niema, M.L., and Vainio H. (1982) Spontaneous abortions in hospital staff engaged in sterilizing instruments with chemical agents. Br. Med. J. 285: 1461–1463.CrossRefGoogle Scholar
  13. Herbst, A.L., Ulfelder, H., and Poskanzer, D.C. (1971) Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women. N. Engl. J. Med. 284: 878–881.PubMedCrossRefGoogle Scholar
  14. Holmberg, P.C. (1979) Central-nervous-system defects in children born to mothers exposed to organic solvents during pregnancy. Lancet ii:177–179.Google Scholar
  15. Infante, P.F. (1979) Oncogenic and mutagenic risks in communities with polyvinyl chloride production facilities. Ann. N.Y. Acad. Sci. 271: 49–57.CrossRefGoogle Scholar
  16. Kalter, H., and Warkany, J. (1983) Congenital malformations: Etiologic factors and their role in prevention. N. Engl. J. Med. 308: 424–431.PubMedCrossRefGoogle Scholar
  17. Kleinbaum, D.G., Kupper, L.L., and Morgenstern, H. (1982) Epidemiologic Research, Lifetime Learning Publications, Belmont, California.Google Scholar
  18. Koos, B.J., and Longo, D.L. (1987) Mercury toxicity in the pregnant woman, fetus, and newborn infant: A review. Am. J. Obstet. Gynecol. 126: 390–409.Google Scholar
  19. Lindbohm, M-L., Taskinen, H., and Hemminki, K. (1985) Reproductive health of working women: Spontaneous abortions and congential malformations. Public Health Rev. 13: 55–87.PubMedGoogle Scholar
  20. Murray, F.J., John, J.A., Balmer, M.F., and Schwetz, B.A. (1978) Teratologic evaluation of styrene given to rats and rabbits by inhalation or by gavage. Toxicology 11: 335–343.PubMedCrossRefGoogle Scholar
  21. Nordstrom, S., Beckman, L., and Nordenson, I. (1979) Occupational and environmental risks in and around a smelter in northern Sweden, V. Spontaneous abortion among female employees and decreased birth weight in their offspring. Hereditas 90: 291–296.PubMedCrossRefGoogle Scholar
  22. O’Leary, J.A., Davies, J.E., Edmundson, W.F., and Feldman, M. (1972) Correlation of prematurity and DDE levels in fetal whole blood. In Epidemiology of DDT ( J.F. Davies and W.F. Edmundsen, Eds.), pp. 55–56, Futura Publishing, Mount Kisco, New York.Google Scholar
  23. Rom, W.N. (1980) Effect of lead on reproduction. In proceedings of a Workshop on Methodology for Assessing Reproductive Hazards in the Workplace (P.F. Infante and M.S. Legator, Eds.), DHHS, NIOSH Publication No. 81–100, pp. 33–42, U.S. Department of Health and Human Services, Washington, D.C.Google Scholar
  24. Sackett, D.L. (1979) Bias in analytic research. J. Chronic Dis. 32: 51–63.PubMedCrossRefGoogle Scholar
  25. Shilling, S., and Lalich, N.R. (1984) Maternal occupation and industry and the pregnancy outcome of U.S. married women, 1980. Public Health Rep. 99: 152–161.PubMedGoogle Scholar
  26. Spence, A.A., and Knill-Jones, R.P. (1978) Is there a health hazard in anaesthetic practice? Br. J. Anaesth. 50: 713–719.PubMedCrossRefGoogle Scholar
  27. Statistics Canada (1982) The Labour Forces, November 1982,Statistics Canada Cat. No. 71–001, Ottawa.Google Scholar
  28. Statistics Canada (1983) Labor Force Occupation Trends,Statistics Canada Cat. No. 92–920, Ottawa.Google Scholar
  29. Stavraky, K.M. (1976) The role of ecologic analysis in studies of the etiology of disease: A discussion with reference to large bowel cancer. J. Chronic Dis. 29: 435–444.PubMedCrossRefGoogle Scholar
  30. Stellman, J.M. (1978) Occupational health hazards of women: An overview. Prey. Med. 7: 281–293.CrossRefGoogle Scholar
  31. Tsubaki, T., and Irukayama, K. (1977) Methylmercury Poisoning in Minamata and Niigata, Japan. Elsevier Press, Amsterdam.Google Scholar
  32. Vessey, M.P., and Nunn, J.F. (1980) Occupational hazards of anaethesia. Br. Med. J. 281: 696–698.PubMedCrossRefGoogle Scholar
  33. Wassermann, M., Ron, M., Bercovici, B., Wassermann, D., Cucos, S., and Pines, A. (1982) Premature delivery and organochlorine compounds: Polychlorinated biphenyls and some organochlorine insecticides. Environ. Res. 28: 106–112.PubMedCrossRefGoogle Scholar
  34. WHO (World Health Organization) (1976) Polychlorinated Biphenyls and Terphenyls, Environmental Health Criteria 2, World Health Organization, Geneva.Google Scholar
  35. WHO (World Health Organization) (1977) Lead, Environmental Health Criteria 2, U.N. Environment Program and World Health Organization, Geneva.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • K. S. Khera
    • 1
  • H. C. Grice
    • 2
  • D. J. Clegg
    • 1
  1. 1.Health Protection BranchHealth and Welfare CanadaOttawaCanada
  2. 2.NepeanCanada

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