Teratogenicity (Embryotoxicity) Studies: Design, Conduct, and Evaluation

  • K. S. Khera
  • H. C. Grice
  • D. J. Clegg
Part of the Current Issues in Toxicology book series (CI TOXICOLOGY)


The principal source of evidence for adverse effects on fetal development that are recognized at term is teratogenicity studies in experimental animals. The design of these studies should be appropriate for the intended purpose, and their conduct should conform to high standards. This is necessary to provide assurance that the data used in risk estimation are sound. In this chapter only basic principles related to these elements are discussed. References cited in the text should be consulted for details regarding the design and conduct of such studies.


Fetal Death Fetal Weight Developmental Toxicity Good Laboratory Practice Fetal Malformation 


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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • K. S. Khera
    • 1
  • H. C. Grice
    • 2
  • D. J. Clegg
    • 1
  1. 1.Health Protection BranchHealth and Welfare CanadaOttawaCanada
  2. 2.NepeanCanada

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