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Behavioral-Functional Teratology

  • K. S. Khera
  • H. C. Grice
  • D. J. Clegg
Part of the Current Issues in Toxicology book series (CI TOXICOLOGY)

Abstract

During the past decade, there has been intense interest in the development of methods to detect subtle changes resulting from in utero and/or perinatal exposure. Because this interest is concerned with protecting society from potential harm, it reflects an advancement in safety assessment (Christian, 1983a; Riley and Vorhees, 1986). Published reports that maternal exposure to lead (Palmisano et al., 1969) and methyl mercury (Matsumoto et al., 1965; Harada, 1968) could produce central nervous system (CNS) disorders in children spurred research activity and regulatory action in behavioral teratology, with an emphasis on neurotoxic effects. Animal models demonstrating neuro-toxic effects somewhat similar to those of humans were soon reported (Spyker et al., 1972; Butcher et al., 1973; Spyker, 1975; Hutchings, 1983).

Keywords

Developmental Toxicity Triethylene Glycol Perinatal Exposure Monobutyl Ether Postnatal Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • K. S. Khera
    • 1
  • H. C. Grice
    • 2
  • D. J. Clegg
    • 1
  1. 1.Health Protection BranchHealth and Welfare CanadaOttawaCanada
  2. 2.NepeanCanada

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