Statistical Methods for Developmental Toxicity Studies
As detailed in the preceding chapters of this monograph, developmental toxicity may be expressed in terms of a number of possible reproductive or teratological abnormalities resulting from exposure to a particular toxicant. Developmental toxicity may be evaluated in studies involving exposure of one or both parents before conception, exposure of the conceptus during pregnancy, or perinatal exposure of the offspring. Multigeneration studies may also be used to assess the cumulative effects of exposure over several generations.
KeywordsToxicity Covariance Infertility Teratogenicity
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