Statistical Methods for Developmental Toxicity Studies

  • K. S. Khera
  • H. C. Grice
  • D. J. Clegg
Part of the Current Issues in Toxicology book series (CI TOXICOLOGY)


As detailed in the preceding chapters of this monograph, developmental toxicity may be expressed in terms of a number of possible reproductive or teratological abnormalities resulting from exposure to a particular toxicant. Developmental toxicity may be evaluated in studies involving exposure of one or both parents before conception, exposure of the conceptus during pregnancy, or perinatal exposure of the offspring. Multigeneration studies may also be used to assess the cumulative effects of exposure over several generations.


Litter Size Developmental Toxicity Litter Effect Unexposed Group Litter Structure 
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • K. S. Khera
    • 1
  • H. C. Grice
    • 2
  • D. J. Clegg
    • 1
  1. 1.Health Protection BranchHealth and Welfare CanadaOttawaCanada
  2. 2.NepeanCanada

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