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miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex Yanli ZhangYingting PangMing Xiao Original Article 04 September 2022 Article: 507
Zebrafish: an important model for understanding scoliosis Haibo XieMingzhu LiChengtian Zhao Review 04 September 2022 Article: 506
Small leucine zipper protein functions as a modulator for metabolic reprogramming of colorectal cancer cells by inducing nutrient stress-mediated autophagy Suhyun KimMinseok OhJesang Ko Original Article 04 September 2022 Article: 505
Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer Miguel A. ZaballosAdrián Acuña-RuizPilar Santisteban Original Article Open access 03 September 2022 Article: 504
Keratin 8 is a scaffolding and regulatory protein of ERAD complexes Iwona Maria PrankeBenoit ChevalierAleksander Edelman Original Article 01 September 2022 Article: 503
Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades Mohamed NoureldeinRashad NawfalAssaad A. Eid OriginalPaper 30 August 2022 Article: 502
The contribution of proteasomal impairment to autophagy activation by C9orf72 poly-GA aggregates Mei PuYusi TaiJin Ren Original Article 29 August 2022 Article: 501
Misfolded protein oligomers induce an increase of intracellular Ca2+ causing an escalation of reactive oxidative species Giulia FaniChiara Ester La TorreFabrizio Chiti Original Article Open access 27 August 2022 Article: 500
Functional diversity of apolipoprotein E: from subcellular localization to mitochondrial function Johanna RueterGerald RimbachPatricia Huebbe Review Open access 26 August 2022 Article: 499
Sertoli cell survival and barrier function are regulated by miR-181c/d-Pafah1b1 axis during mammalian spermatogenesis Yue FengDake ChenFenge Li Original Article Open access 25 August 2022 Article: 498
The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA) Nora Tula DeteringTobias SchüningPeter Claus Review 25 August 2022 Article: 497
Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex Jorge Ramirez-FrancoFodil AzzazOussama El Far Original Article 25 August 2022 Article: 496
Cdk5 regulates IP3R1-mediated Ca2+ dynamics and Ca2+-mediated cell proliferation Saranya NavaneethaKrishnanVincent LawKi-Young Lee Original Article Open access 24 August 2022 Article: 495
Aging impairs arterial compliance via Klotho-mediated downregulation of B-cell population and IgG levels Jun FanShirley WangZhongjie Sun Original Article 24 August 2022 Article: 494
Convergent evolutionary counterion displacement of bilaterian opsins in ciliary cells Kazumi SakaiHiroki IkeuchiTakahiro Yamashita Original Article 24 August 2022 Article: 493
Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system Lee E. EidenVito S. HernándezLimei Zhang Review 23 August 2022 Article: 492
Environmental and intrinsic modulations of venous differentiation Laurence Pibouin-FragnerAnne EichmannLuc Pardanaud Original Article 20 August 2022 Article: 491
Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs Azman Embarc-BuhRosario Francisco-VelillaEncarnacion Martinez-Salas Original Article Open access 20 August 2022 Article: 490
Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process Antero Salminen Review Open access 20 August 2022 Article: 489
Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis Yunhui ZhangWenjie LiuPeng Wang Original Article Open access 19 August 2022 Article: 488
WWOX inhibition by Zfra1-31 restores mitochondrial homeostasis and viability of neuronal cells exposed to high glucose Cristina CarvalhoSónia C. CorreiaPaula I. Moreira Original Article 19 August 2022 Article: 487
New insights into the bile acid-based regulatory mechanisms and therapeutic perspectives in alcohol-related liver disease Yali LiuTao LiuYanhang Gao Review 17 August 2022 Article: 486
Effect of chronic stress on tumorigenesis and development Chen WangYumeng ShenYong Yang Review 16 August 2022 Article: 485
A context-dependent and disordered ubiquitin-binding motif Jesper E. DreierAndreas PrestelBirthe B. Kragelund Original Article Open access 16 August 2022 Article: 484
Excess intracellular ATP causes neuropathic pain following spinal cord injury Nobuhiko NakajimaYuichiro OhnishiHaruhiko Kishima Original Article 16 August 2022 Article: 483
Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance Qijing LiJianghong ZhongRikard Holmdahl Original Article Open access 14 August 2022 Article: 482
mRNA m5C inhibits adipogenesis and promotes myogenesis by respectively facilitating YBX2 and SMO mRNA export in ALYREF-m5C manner Youhua LiuYing YangXinxia Wang Original Article 12 August 2022 Article: 481
Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target Douglas ArnesonGuanglin ZhangXia Yang Original Article Open access 11 August 2022 Article: 480
Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells Lisa EppingChristina B. SchroeterSven G. Meuth Original Article Open access 11 August 2022 Article: 479
Pharmacological attenuation of melanoma by tryptanthrin pertains to the suppression of MITF-M through MEK/ERK signaling axis Anwar ShabnaJayesh AntonyRuby John Anto Original Article 10 August 2022 Article: 478
Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells Nicole KollerPhilipp HöllthalerRobert Tampé Original Article Open access 10 August 2022 Article: 477
Thyroid hormone signaling in the intestinal stem cells and their niche Maria Virginia GiolitoMichelina Plateroti Review 10 August 2022 Article: 476
A previously unknown Argonaute 2 variant positively modulates the viability of melanoma cells Lisa Linck-PaulusTina MeißgeierAnja K. Bosserhoff Original Article Open access 09 August 2022 Article: 475
Emerging role of tumor suppressor p53 in acute and chronic kidney diseases Jessica M. OverstreetCody C. GiffordRohan Samarakoon Review 09 August 2022 Article: 474
Mechanisms involved in hematopoietic stem cell aging Takeshi FujinoShuhei AsadaToshio Kitamura Review 08 August 2022 Article: 473
Unspliced XBP1 contributes to cholesterol biosynthesis and tumorigenesis by stabilizing SREBP2 in hepatocellular carcinoma Mankun WeiUli NurjanahVivi Kasim Original Article 06 August 2022 Article: 472
Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy Vilmos TóthHenrietta VadásziJózsef Kardos Original Article Open access 06 August 2022 Article: 471
Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights Bowen LiBo YangWei Chen Review 06 August 2022 Article: 470
BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner Zengli LiuChunxiao HuYunfei Xu Original Article 06 August 2022 Article: 469