Sec62 promotes gastric cancer metastasis through mediating UPR-induced autophagy activation Song SuYan-Ting ShiJie Liang Original Article 15 February 2022 Article: 133
Leveraging multiomics approaches for producing lignocellulose degrading enzymes Kavya DashoraMeghana GattupalliShilpi Srivastava Review 13 February 2022 Article: 132
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders José A. MansoTamara MarcosAndrés Alonso Original Article Open access 12 February 2022 Article: 131
Maybe you can turn me on: CRISPRa-based strategies for therapeutic applications Elvir Becirovic Review Open access 12 February 2022 Article: 130
Hydrogen peroxide-induced stress acclimation in plants Muhammad Kamran QureshiPiotr GawrońskiPavel Kerchev Review 09 February 2022 Article: 129
Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex Siqi WuLi ZhengPengfei Fang Original Article 08 February 2022 Article: 128
Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias Giuditta Dal CortivoCarlo Giorgio BarracchiaDaniele Dell’Orco Original Article Open access 08 February 2022 Article: 127
The wide and growing range of lamin B-related diseases: from laminopathies to cancer Camilla EvangelistiIsabella RuscianoStefano Ratti Review Open access 08 February 2022 Article: 126
Structure and function of an atypical homodimeric actin capping protein from the malaria parasite Ábris Ádám BendesPetri KursulaInari Kursula Original Article Open access 08 February 2022 Article: 125
CDNF and MANF regulate ER stress in a tissue-specific manner Emmi PakarinenPäivi LindholmMaria Lindahl Original Article Open access 07 February 2022 Article: 124
Coding and long non-coding gene expression changes in the CNS traumatic injuries Xizi WuHaichao WeiJia Qian Wu Review 07 February 2022 Article: 123
Syndecan-4 affects myogenesis via Rac1-mediated actin remodeling and exhibits copy-number amplification and increased expression in human rhabdomyosarcoma tumors Kitti SzaboDaniel VargaAniko Keller-Pinter Original Article Open access 07 February 2022 Article: 122
Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-β receptor in vascular smooth muscle cells Rizwana AfrozHirushi KumarapperumaDanielle Kamato Original Article Open access 05 February 2022 Article: 121
A mitochondria cluster at the proximal axon initial segment controls axodendritic TAU trafficking in rodent primary and human iPSC-derived neurons Noah TjiangHans Zempel Original Article Open access 04 February 2022 Article: 120
Regulatory mechanisms of cytoneme-based morphogen transport Christina A. DalyEric T. HallStacey K. Ogden Review Open access 04 February 2022 Article: 119
The roles of transmembrane family proteins in the regulation of store-operated Ca2+ entry Ningxia ZhangHongming PanWeidong Han Review 04 February 2022 Article: 118
Pro-apoptotic and anti-apoptotic regulation mediated by deubiquitinating enzymes Hae-Seul ChoiKwang-Hyun Baek Review 03 February 2022 Article: 117
Molecular mechanisms associated with chemoresistance in esophageal cancer Matheus Lohan-CodeçoMaria Luísa Barambo-WagnerAntonio Palumbo Jr Review 03 February 2022 Article: 116
Reliability of a novel approach for reference-based cell type estimation in human placental DNA methylation studies Linda DieckmannCristiana CruceanuDarina Czamara Original Article Open access 03 February 2022 Article: 115
LncRNA Tug1 maintains blood–testis barrier integrity by modulating Ccl2 expression in high-fat diet mice Shuxian WangZhang QianBing Yao Original Article 01 February 2022 Article: 114
Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions Svetlana KatchkovskyBiplab ChatterjeeNoam Levaot Original Article 31 January 2022 Article: 113
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells Hongli YinOzge KarayelDaniel Krappmann Original Article Open access 31 January 2022 Article: 112
Efficient gene editing through an intronic selection marker in cells Shang WangYuqing LiYuanzhong Wu Original Article Open access 31 January 2022 Article: 111
The association of telomere maintenance and TERT expression with susceptibility to human papillomavirus infection in cervical epithelium Li-Na WangLi WangDawei Xu Original Article 31 January 2022 Article: 110
Generation of dystrophin short product-specific tag-insertion mouse: distinct Dp71 glycoprotein complexes at inhibitory postsynapse and glia limitans Takahiro FujimotoTakeshi YaoiKyoko Itoh Original Article 30 January 2022 Article: 109
PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages Ling-Ya ChiuDuen-Yi HuangWan-Wan Lin Original Article Open access 30 January 2022 Article: 108
Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/β-catenin signaling Meng ChenLiying ShanBaoli Wang Original Article 30 January 2022 Article: 107
Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis Qi LiuPengyue DuZiwei Zhang Original Article 30 January 2022 Article: 106
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury Shanshan SongZhangping XiaoBarbro N. Melgert Review Open access 29 January 2022 Article: 105
MED12 is overexpressed in glioblastoma patients and serves as an oncogene by targeting the VDR/BCL6/p53 axis Srishti SrivastavaHima MakalaRitu Kulshreshtha Original Article 29 January 2022 Article: 104
The role of mitonuclear incompatibilities in allopatric speciation Ronald S. Burton Review 29 January 2022 Article: 103
A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection Michelle C. C. LimGunter MaubachMchael Naumann Original Article Open access 28 January 2022 Article: 102
Revisiting APP secretases: an overview on the holistic effects of retinoic acid receptor stimulation in APP processing José J. M. VitóriaDiogo TrigoOdete A. B. da Cruz e Silva Review 28 January 2022 Article: 101
Integrin-linked kinase (ILK): the known vs. the unknown and perspectives Agata GórskaAntonina Joanna Mazur Review Open access 28 January 2022 Article: 100
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through β-catenin dysregulation Byeong-Yun AhnMyong-Ho JeongJong-Sun Kang Original Article 28 January 2022 Article: 99
Sialic acid blockade in dendritic cells enhances CD8+ T cell responses by facilitating high-avidity interactions N. BalnegerL. A. M. CornelissenG. J. Adema Original Article Open access 28 January 2022 Article: 98
Microtubule-associated protein tau in murine kidney: role in podocyte architecture Laura Vallés-SaizRocio Peinado-CahucholaFélix Hernández Original Article Open access 27 January 2022 Article: 97
Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells Anna HolthenrichJulian TerglaneVolker Gerke Original Article Open access 27 January 2022 Article: 96
Autophagosome–lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process Sumin SonAhruem BaekDong-Eun Kim Original Article 26 January 2022 Article: 95
Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives Oskar CiesielskiMarta BiesiekierskaAneta Balcerczyk Review Open access 25 January 2022 Article: 94
Zyxin protects from hypertension-induced cardiac dysfunction Jaafar Al-HasaniCarla Sens-AlbertMarkus Hecker Original Article Open access 24 January 2022 Article: 93
Revisiting ZAR proteins: the understudied regulator of female fertility and beyond Yu-Ke WuHeng-Yu Fan Review 24 January 2022 Article: 92
Mitochondrial regulation during male germ cell development Xiaoli WangLisha YinShuiqiao Yuan Review 24 January 2022 Article: 91
Aquaporin-4 expression in the human choroid plexus Felix DeffnerCorinna GleiserAndreas F. Mack Original Article Open access 24 January 2022 Article: 90
miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages Dominik C. FuhrmannBernhard Brüne Original Article Open access 24 January 2022 Article: 89
JAM-A interacts with α3β1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells Sonja ThölmannJochen SeebachKlaus Ebnet Original Article Open access 24 January 2022 Article: 88
Defects in aminoacyl-tRNA synthetase cause partial B and T cell immunodeficiency Ju A. ShimYuna JoChangwan Hong Original Article 23 January 2022 Article: 87
Helicobacter pylori-induced reactive oxygen species direct turnover of CSN-associated STAMBPL1 and augment apoptotic cell death Supattra ChaithongyotMichael Naumann Original Article Open access 23 January 2022 Article: 86
Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling Niki SarriKehuan WangNatalia Papadopoulos Original Article Open access 21 January 2022 Article: 85
Circulating cardiomyocyte-derived extracellular vesicles reflect cardiac injury during systemic inflammatory response syndrome in mice Hargita HegyesiÉva PallingerEdit I. Buzás Original Article Open access 20 January 2022 Article: 84