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Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

  • Plant-borne compounds and nanoparticles: challenges for medicine, parasitology and entomology
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Abstract

The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology and tropical medicine. Eco-friendly vector control programs are crucial to fight, besides malaria, the spread of dengue, West Nile, chikungunya, and Zika virus, as well as other arboviruses such as St. Louis encephalitis and Japanese encephalitis. However, research efforts on the control of mosquito vectors are experiencing a serious lack of eco-friendly and highly effective pesticides, as well as the limited success of most biocontrol tools currently applied. Most importantly, a cooperative interface between the two disciplines is still lacking. To face this challenge, we have reviewed a wide number of promising results in the field of green-fabricated pesticides tested against mosquito vectors, outlining several examples of synergy with classic biological control tools. The non-target effects of green-fabricated nanopesticides, including acute toxicity, genotoxicity, and impact on behavioral traits of mosquito predators, have been critically discussed. In the final section, we have identified several key challenges at the interface between "green" nanotechnology and classic biological control, which deserve further research attention.

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Acknowledgements

Giovanni Benelli is grateful to the One Health Initiative (www.onehealthinitiative.com) for hosting him as supporter. Giovanni Benelli would like to thank Laura Kahn and Bruce Kaplan for their helpful suggestions on the topic of this review.

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Authors and Affiliations

  1. Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124, Pisa, Italy

    Giovanni Benelli

  2. School of Pharmacy, University of Camerino, Via Sant’Agostino 1, 62032, Camerino, Italy

    Filippo Maggi, Riccardo Petrelli & Loredana Cappellacci

  3. Crop Research Institute, Drnovska 507, 16106, Prague 6, Czech Republic

    Roman Pavela

  4. Department of Biotechnology, Thiruvalluvar University, Serkkadu, Vellore, Tamil Nadu, 632 115, India

    Kadarkarai Murugan

  5. Unit of Vector Control, Phytochemistry and Nanotechnology, Department of Zoology, Annamalai University, Annamalainagar, Tamil Nadu, 608 002, India

    Marimuthu Govindarajan

  6. Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, 630004, India

    Baskaralingam Vaseeharan

  7. Department of Medical Microbiology and Parasitology, 43400, Serdang, Malaysia

    Suresh Kumar

  8. Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden

    Anders Hofer

  9. Department of Veterinary Parasitology, Babol-Branch, Islamic Azad University, Babol, Iran

    Mohammad Reza Youssefi

  10. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia

    Abdullah A. Alarfaj

  11. Institute of Marine Biology, National Taiwan Ocean University, Keelung, 20224, Taiwan

    Jiang-Shiou Hwang

  12. Department of Chemical and Materials Engineering, National Central University, Taoyuan, 32001, Taiwan

    Akon Higuchi

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  1. Giovanni Benelli
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  2. Filippo Maggi
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  5. Marimuthu Govindarajan
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  9. Suresh Kumar
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  11. Mohammad Reza Youssefi
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  12. Abdullah A. Alarfaj
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  13. Jiang-Shiou Hwang
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  14. Akon Higuchi
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Corresponding author

Correspondence to Giovanni Benelli.

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Funding

The Authors extend our appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding through ISPP no. 0062. J.-S. Hwang thanks the Ministry of Science and Technology of Taiwan (grant no. NSC98-2621-B-019-001-MY3, NSC101-2621-B-019-002, and NSC102-2923-B-019-001-MY3) for the financial support. R. Pavela would like to thank the Technology Agency of the CR (Project no. TA04020103). A. Higuchi is grateful to the National Science Council of Taiwan under Grant no. MOST-104-2221-E-008-107-MY3 and MOST-105-2119-M-008-006, as well as to a Grant-in-Aid for Scientific Research (15K06591) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. F. Maggi, R. Petrelli, and L. Cappellacci would like to thank University of Camerino (FAR 2014/15, FPI000044) for the financial support. A. Hofer thanks the Swedish Research Council (2012–1932) and the Kempe Foundation. Lastly, we acknowledge the International High Cited Research Group (IHCRG no. 14-104), Deanship of Scientific Research, King Saud University, Riyadh, Kingdom of Saudi Arabia. Funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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The authors declare no competing interests.

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Responsible editor: Philippe Garrigues

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Benelli, G., Maggi, F., Pavela, R. et al. Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects. Environ Sci Pollut Res 25, 10184–10206 (2018). https://doi.org/10.1007/s11356-017-9752-4

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