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Prostaglandin and Lipid Metabolism in Radiation Injury

  • Book
  • © 1987

Overview

Editors:
  1. Thomas L. Walden

    1. Armed Forces Radiobiology Research Institute, Bethesda, USA

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  2. Haywood N. Hughes

    1. Armed Forces Radiobiology Research Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Radiation Effects on Lipid Synthesis and Membrane Damage

    1. Front Matter

      Pages 1-1
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    2. Radiation Peroxidation in Model Membranes

      • J. A. Raleigh
      Pages 3-27

    3. Role of Membrane Lipid Composition in Radiation- Induced Death of Mammalian Cells

      • A. W. T. Konings
      Pages 29-43

    4. Influence of Membrane Lipid Composition and Organization on Radio-and Thermosensitivity of Bacteria

      • M. B. Yatvin, O. Yukawa, W. H. Dennis
      Pages 45-57

    5. Role of Membranes, Free Radicals, and Copper in Radiation-Induced Changes in Quaternary Structure of DNA: Some Clinical Implications

      • W. A. Cramp, A. M. George, J. C. Edwards, S. A. Sabovljev, G. Harris, L. E. Hart et al.
      Pages 59-72

    6. Role of Lipid Peroxidation in Radiation Damage and Repair of Cell Membranes in the Thermophilic Bacterium Thermus Thermophilus

      • S. Suzuki
      Pages 73-77

    7. Macromolecule Effects on Prostacyclin Production and Measurement

      • R. M. Price, D. M. Gersten, P. W. Ramwell
      Pages 79-83

    8. Inositol Lipid Turnover, Ca2+ Mobilization, and Increased Ca2+ Influx in Heat-Stressed Cells

      • M. A. Stevenson, E. K. Farnum, G. M. Hahn, S. K. Calderwood
      Pages 85-90

    9. Role of Antioxidant Nutrients in Preventing Retinal Damage During Hyperbaric Oxygen Treatment

      • A. L. Hollis, R. A. Henderson, W. L. Stone
      Pages 91-95

    10. Effects of Phenylhydrazine on Human Red Cell Membrane Aminophospholipids: A Fluorescamine Study

      • Z. Chen, A. Stern
      Pages 97-101

    11. Role of Oxygen Radicals in Peroxidation of Docosahexaenoic Acid by Rat Brain Homogenate in vitro

      • T. Shingu, N. Salem Jr.
      Pages 103-108

    12. Possible Involvement of Queuine in Oxidative Metabolism

      • L. Szabo, W. R. Farkas
      Pages 109-114

    13. Cytochrome P-450 Interaction with Arachidonic Acid Hydroperoxides: Role in Lipid Peroxidation

      • R. H. Weiss, J. L. Arnold, R. W. Estabrook
      Pages 115-119

    14. Leakage of Fatty Acid Radicals During Lipoxygenase Catalysis

      • C. Kemal, L.-C. Yuan, K. Laurenzo
      Pages 121-126

    15. The Mast Cell Granule: A Phospholipid Source for Prostaglandin Synthesis

      • S. P. Chock, E. A. Schmauder-Chock
      Pages 127-132
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Keywords

About this book

This volume contains the proceedings of the International Conference on Prostaglandins and Lipid Metabolism in Radiation Injury held in Rockville, Maryland, on October 2-3, 1986. Over 200 persons from eight countries attended the program, which consisted of 24 oral presentations and 38 poster presentations. Forty-two of those presentations have been included in this volume. The conference was sponsored by the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland. The effects of radiation on lipid synthesis and membrane damage are aptly summarized in the first five chapters. These chapters describe the effects of radiation on lipid peroxidation of model membranes, and the role of lipid composition in mammalian cell death and in bacterial radio- and thermosensitivity. In bacteria, lipid peroxidation is not essential for radiation-induced cell death. One of the key points of the conference was the paradoxical nature of the radiobiology of eicosanoids. On the one hand, eicosanoids are mediators of damage; on the other, they are radioprotective agents. It is clear from the literature and from the data presented at the conference that both of these properties may also be observed as a consequence of radiotherapy. Some studies indicate that nonsteroidal anti-inflammatory drugs may minimize or prevent certain radiation­ induced damage, but other studies show no positive effect.

Editors and Affiliations

  • Armed Forces Radiobiology Research Institute, Bethesda, USA

    Thomas L. Walden, Haywood N. Hughes

Bibliographic Information

  • Book Title: Prostaglandin and Lipid Metabolism in Radiation Injury

  • Editors: Thomas L. Walden, Haywood N. Hughes

  • DOI: https://doi.org/10.1007/978-1-4684-5457-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1987

  • Softcover ISBN: 978-1-4684-5459-8Published: 08 March 2012

  • eBook ISBN: 978-1-4684-5457-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 420

  • Topics: Cell Biology, Protein Science

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