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Contemporary Topics in Immunobiology

Volume 3

  • M. G. Hanna
  • Max D. Cooper
  • Noel L. Warner

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Richard K. Gershon
    Pages 1-40
  3. Leonore A. Herzenberg, Leonard A. Herzenberg
    Pages 41-75
  4. Rose Lieberman, William E. Paul
    Pages 117-139
  5. Joseph M. Davie, William E. Paul
    Pages 171-192
  6. Alexander R. Lawton III, Max D. Cooper
    Pages 193-225
  7. Henry H. Wortis
    Pages 243-263
  8. Back Matter
    Pages 265-267

About this book

Introduction

Contemporary immunobiology is an ever-diversifying field that embraces many aspects of cellular and humoral immune responsiveness. This includes the phylogeny, ontogeny, induction, regulation, expression, and differentiation of the immune-cell series, as well as the relationship of these to the pathogenesis of many disease processes. It is clearly beyond the limitations of each volume in this series to comprehensively cover progress in each of these fields. Three general areas of contemporary investigations are discussed in the current issue: cellular events of B cell differentiation, including antigen recognition and respon­ siveness of B lymphocytes; regulation of the immune response by T cells, and the roles of this regulatory system in allotype suppression and in autoimm unity; and the genetic control of immune responses and its possible relation to disease pathogenesis. Analysis of responsiveness of B lymphocytes has been greatly aided by the availability of athymic nude mice. The immunological responsiveness of these mice to a wide range of stimuli has been reviewed and analyzed by H. H. Wortis. This article concludes with the provocative thesis that in the future "nudes will supply new rather than confirmatory data . . . (especially regarding) the develop­ ment of neoplasia. " In contrast to the studies on the congenitally athymic mice, G. F.

Keywords

antigen immune response immunobiology lymphocytes pathogenesis

Editors and affiliations

  • M. G. Hanna
    • 1
  • Max D. Cooper
    • 2
  • Noel L. Warner
    • 3
  1. 1.Oak Ridge National LaboratoryOak RidgeUSA
  2. 2.University of AlabamaBirminghamUSA
  3. 3.The Walter and Eliza Hall InstituteAustralia

Bibliographic information