Short-Term and Chronic Allotype Suppression in Mice

  • Leonore A. Herzenberg
  • Leonard A. Herzenberg


The phenomenon called allotype suppression, in which exposure of the neonate to antibody against its own immunoglobulins suppresses production of those immunoglobulins, offers fertile ground for studying the mechanisms of differentiation and regulation of the immune system. Frequently the suppression is short-lived, and is measurable in weeks post exposure rather than months. In other cases, however, the short exposure of the young animal to antibody to an allotypic antigen on immunoglobulins appears to permanently modify the immune system of the treated animal so that it never regains its normal capacity for immunoglobulin production. Studies on the mechanisms of these short- and long-term suppressions may therefore be expected to provide useful information about some of the sensitive regulation points which keep the entire immune system in balance.


Spleen Cell Suppressor Cell Normal Spleen Chronic Suppression Immunoglobulin Synthesis 
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  1. Appella, E., Mage, R. G., Dubiski, S., and Reisfeld, R., 1968.Proc. Nat. Acad. Sci. 60:975.Google Scholar
  2. Baker, P. J., Stashak, R. W., Amsbaugh, D. F., Prescott, B., and Barth, R. F., 1970. J. Immunol 105: 1581.PubMedGoogle Scholar
  3. Brambell, F. W. R., 1970. The Transmission of Passive Immunity from Mother to Young. American-Elsevier, New York. Cebra, J. J., 1968. Symp. Intern. Soe. Cell Biol. 7: 69.Google Scholar
  4. Claman, H. N., and Chaperon, E. A., 1969. Transpl. Rev. 1: 92.Google Scholar
  5. Cunningham, A. J. and Sercarz, E. E., 1971. Eur. J. Immunol 1: 413.PubMedCrossRefGoogle Scholar
  6. David, G. S., and Todd, C. W., 1969. Proc. Nat. Acad. Sci. 62: 860.PubMedCrossRefGoogle Scholar
  7. Davies, A. J. S., 1969. Transpl Rev. 1: 43.Google Scholar
  8. Dray, S., 1962. Nature 195: 181.CrossRefGoogle Scholar
  9. Dunn, T. B., and Derringer, M. K., 1968. J. Nat. Cancer Inst. 40: 771.PubMedGoogle Scholar
  10. Feldmann, M., 1972. J. Exp. Med. 136: 737.PubMedCrossRefGoogle Scholar
  11. Gershon, R. K., 1973. Contemporary Topics in Immunobiology, Vol. 3. Plenum Press, New York.Google Scholar
  12. Grumet, F.C., 1972. J. Exp. Med. 135: 110.PubMedCrossRefGoogle Scholar
  13. Gustafsson, B. E., and Laurell, C. B., 1959. J. Exp. Med. 110: 675.Google Scholar
  14. Harrison, M. R., Mage, R. G., and Davie, J. M., 1973. J. Exp. Med. 137: 254.PubMedCrossRefGoogle Scholar
  15. Hellström, K. E., and Hellström, I., 1972. In Ontogeny of Acquired Immunity: A Ciba Foundation Symposium, Assoc. Sci. Publ., New York, p. 133.Google Scholar
  16. Henry, C., and Jerne, N. K., 1967. In J. Killander (ed.), Gamma Globulins Nobel Symp., Vol. 3, Almquist and Wiksell, Stockholm, p. 421.Google Scholar
  17. Herzenberg, L. A., 1972. In Ciba Foundation Symposium: Ontogeny of Acquired Immunity. Associated Scientific Publishers, New York. pp. 106 – 112.Google Scholar
  18. Herzenberg, L. A., and Herzenberg, L. A., 1973. In D. M. Weir (ed.), Handbook of Experimental Immunology, 2nd ed., Blackwell Scientific Publications. Oxford, pp. 13.1–13.18.Google Scholar
  19. Herzenberg, L. A., and Herzenberg, L. A., 1966. In Proceedings of Symposium on the Mutational Process, Czechoslovakian Acad. Sciences, Praha, pp. 227 – 232.Google Scholar
  20. Herzenberg, L. A., Chan, E. L., Ravitch, M. M., Riblet, R. J., and Herzenberg, L. A., 1973. J. Exp. Med. 137: 1131.CrossRefGoogle Scholar
  21. Herzenberg, L. A., Jacobson, E. B., Herzenberg, L. A., and Riblet, R. J., 1971. Ann. N.Y. Acad. Sci. 190: 212.PubMedCrossRefGoogle Scholar
  22. Herzenberg, L. A., McDevitt, H. O., and Herzenberg, L. A., 1968. Ann. Rev. Genet. 2: 209.CrossRefGoogle Scholar
  23. Herzenberg, L. A., Herzenberg, L. A., Goodlin, R. C., and Rivera, E. C., 1961. J. Exp. Med. 126: 701.CrossRefGoogle Scholar
  24. Iverson, G. M., 1972. In Silvestri (ed.), Lepetit Symposium, North Holland Publishing Co., Amsterdam.Google Scholar
  25. Jacobson, E. B., and Herzenberg, L. A., 1972. J. Exp. Med. 135: 1151.PubMedCrossRefGoogle Scholar
  26. Jacobson, E. B., Herzenberg, L. A., Riblet, R. J., and Herzenberg, L. A., 1972. J. Exp. Med. 135: 1163.PubMedCrossRefGoogle Scholar
  27. Jacobson, E. B., L’age-Stehr, J., and Herzenberg, L. A., 1970. J. Exp. Med. 131:1109.Google Scholar
  28. Kerbel, R. S., and Eidinger, D., 1972. Eur. J. Immunol. 2: 114.PubMedCrossRefGoogle Scholar
  29. Kim, B. S., and Dray, S., 1973. Eur. J. Immunol Google Scholar
  30. Lawton, A. R., Asofsky, R., Hylton, M. B., and Cooper, M. D., 1972. J. Exp. Med. 135: 277.PubMedCrossRefGoogle Scholar
  31. Lummus, Z., Cebra, J., and Mage, R. G., 1967. J. Immunol. 99: 737.PubMedGoogle Scholar
  32. Mage, R. G., 1967. Cold Spring Harbor Symp. Quant. Biol. 32: 203.CrossRefGoogle Scholar
  33. Mage, R. G., and Dray, S., 1965. J. Immunol. 95: 525.PubMedGoogle Scholar
  34. Mäkeläa, O., Cross, A., and Kosunen, T. U., 1971. Cell Interactions and Receptor Antibodies in Immune Responses. Academic Press, London.Google Scholar
  35. Manning, D. D., and Jutila, J. W., 1972. J. Exp. Med. 135: 1316.PubMedCrossRefGoogle Scholar
  36. Miller, J. F. A. P., and Mitchell, G. F., 1969. Transpl. Rev. 1: 3.Google Scholar
  37. Mishell, R., and Dutton, R., 1967. J. Exp. Med. 126: 423.PubMedCrossRefGoogle Scholar
  38. Mitchell, G. F., Chan, E. L., Noble, M. S., Weissman, I. L., Mishell, R. I., and Herzenberg, L. A., 1972a. J. Exp. Med. 135: 165.PubMedCrossRefGoogle Scholar
  39. Mitchell, G. F., Grumet, F. C., and McDevitt, H. O., 19726. J. Exp. Med. 135: 126.Google Scholar
  40. Mitchell, G. F., Mishell, R. I., and Herzenberg, L. A., 1971. In B. Amos (ed.), Progress in Immunology, Vol. 1. Academic Press, New York, p. 323.Google Scholar
  41. Mitchison, N. A., 1967. Cold Spring Harbor Symp. Quant. Biol. 32: 432.CrossRefGoogle Scholar
  42. Okamura, K., and Tada, T., 1971. J. Immunol. 107: 1682.Google Scholar
  43. Old, L. J., and Carswell, E., personal communication.Google Scholar
  44. Paul, W. E., Siskind, G. V., Benacerraf, B., and Ovary, Z., 1967. J. Immunol. 99: 760.PubMedGoogle Scholar
  45. Pernis, B. G., Chiappino, A. S. K. and Gell, P. G. H., 1965. J. Exp. Med. 122: 853.PubMedCrossRefGoogle Scholar
  46. Pierce, C. W., Solliday, S. M., and Asofsky, R., 1972. J. Exp. Med. 135: 698.PubMedCrossRefGoogle Scholar
  47. Rabellino, E. Colon, S., Grey, H. M., and Unanue, E. R., 1971. J. Exp. Med. 133: 156.Google Scholar
  48. Raff, M. C., 1971. Transpl. Rev. 6: 52.Google Scholar
  49. Raff, M. C., 1970. Nature (London) 226: 1257.Google Scholar
  50. Raff, M. C., Sternberg, M., and Taylor, R. B., 1970. Nature 225: 553.PubMedCrossRefGoogle Scholar
  51. Rajewsky, K., Chirrmacher, V., Nase, S., and Jerne, N. K., 1969. J. Exp. Med. 129: 1131.PubMedCrossRefGoogle Scholar
  52. Reif, A. E. and Allen, J. M., 1964. J. Exp. Med. 120: 413.PubMedCrossRefGoogle Scholar
  53. Staats, J., 1972. Cancer Res. 32: 1609.PubMedGoogle Scholar
  54. Taylor, R. B., 1969. Transpl. Rev. 1: 114.Google Scholar
  55. Tyan, M. L., and Herzenberg, L. A., 1968. J. Immunol. 101: 446.PubMedGoogle Scholar
  56. Wanebo, H. J., Gallmeier, W. M., Boyse, E. A., and Old, L. J., 1966. Science 154: 901.PubMedCrossRefGoogle Scholar
  57. Wang, A. C., Wilson, S. K., Hopper, J. E., Fudenberg, H. H., and Nisonoff, A., 1970. Proc. Nat. Acad. Sci. 66: 337.PubMedCrossRefGoogle Scholar
  58. Warner, N. L., 1972. Contemporary Topics in Immunology Vol. 1, p. 87. Plenum Press, New York.Google Scholar
  59. Warner, N. L., and Herzenberg, L. A., 1970. J. Exp. Med. 132: 440.PubMedCrossRefGoogle Scholar
  60. Warner, N. L., Szenberg, A., and Burnet, F. M., 1962. Aust. J. Exp. Biol. 40: 373.CrossRefGoogle Scholar
  61. Wigzell, H., Andersson, B., Mäkelä, O., and Walters, C. S., 1971. In O. Mäkelä, A. Cross, and T. V. Kosunen (eds.), Cell Interactions and Receptor Antibodies in Immune Responses, Academic Press, New York.Google Scholar
  62. Wortis, H. H., 1971. Clin. Exp. Immunol. 6: 305.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Leonore A. Herzenberg
    • 1
  • Leonard A. Herzenberg
    • 1
  1. 1.Department of GeneticsStanford University School of MedicineStanfordUSA

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